Quick answers
- What is Diphenhydramine and naproxen used for?
- The Drug Facts label of Good Sense Naproxen Sodium (L. Perrigo Company) lists these uses: for relief of occasional sleeplessness when associated with minor aches and pains; helps you fall asleep and stay asleep.
- Do I need a prescription for Diphenhydramine and naproxen?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Diphenhydramine and naproxen been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Good Sense Naproxen Sodium · L. Perrigo Company
Diphenhydramine hydrochloride 25 mg · Naproxen sodium 220 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Diphenhydramine hydrochloride 25 mg Naproxen sodium 220 mg (naproxen 200 mg) (NSAID)* *nonsteroidal anti-inflammatory drug
Purpose
Nighttime sleep-aid Pain reliever
Uses
- for relief of occasional sleeplessness when associated with minor aches and pains
- helps you fall asleep and stay asleep
Warnings
- Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- skin reddening
- rash
- blisters If an allergic reaction occurs, stop use and seek medical help right away.
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use
- if you have ever had an allergic reaction to any other pain reliever/fever reducer
- unless you have time for a full night’s sleep
- in children under 12 years of age
- right before or after heart surgery
- with any other product containing diphenhydramine, even one used on skin
- if you have sleeplessness without pain
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers or fever reducers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
- you have a breathing problem such as emphysema or chronic bronchitis
- you have glaucoma
- you have trouble urinating due to an enlarged prostate gland
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers, or any other sleep-aid
- under a doctor’s care for any serious condition
- taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin
- taking any other antihistamines
- taking any other drug
When using this product
- drowsiness will occur
- avoid alcoholic drinks
- do not drive a motor vehicle or operate machinery
- take with food or milk if stomach upset occurs
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms of heart problems or stroke:
- chest pain
- trouble breathing
- weakness in one part or side of body
- slurred speech
- leg swelling
- pain gets worse or lasts more than 10 days
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness.
- redness or swelling is present in the painful area
- any new symptoms appear
- you have difficulty swallowing
- it feels like the pill is stuck in your throat If pregnant or breast feeding ask a health professional before use. It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
Directions
- do not take more than directed
- drink a full glass of water with each dose
- adults and children 12 years and over: take 2 caplets at bedtime
- do not take more than 2 caplets in 24 hours
- if taken with food, this product may take longer to work
Inactive ingredients
croscarmellose sodium, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, titanium dioxide
Questions?
1-800-719-9260
— FDA label of Good Sense Naproxen Sodium, L. Perrigo Company, effective May 11, 2026. See the official label on DailyMed →
Naproxen Sodium and Diphenhydramine HCL · Target Corporation
Diphenhydramine hydrochloride 25 mg · Naproxen sodium 220 mg, tablet (oral)
Active ingredient (in each caplet)
Diphenhydramine Hydrochloride 25 mg Naproxen Sodium 220 mg (naproxen 200 mg) (NSAID)* * nonsteroidal anti-inflammatory drug
Purpose
Nighttime sleep aid Pain reliever
Uses
- for relief of occasional sleeplessness when associated with minor aches and pains
- helps you fall asleep and stay asleep
Warnings
- Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- skin reddening
- rash
- blisters If an allergic reaction occurs, stop use and seek medical help right away.
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if use more than directed or for longer than directed.
Do not use
- if you have ever had an allergic reaction to any other pain reliever/fever reducer
- unless you have time for a full night’s sleep
- in children under 12 years of age
- right before or after heart surgery
- with any other product containing diphenhydramine, even one used on skin
- if you have sleeplessness without pain
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers or fever reducers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
- you have a breathing problem such as emphysema or chronic bronchitis
- you have glaucoma
- you have trouble urinating due to an enlarged prostate gland
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers, or any other sleep-aid
- under a doctor's care for any serious condition
- taking aspirin for heart attack or stroke, because naproxen may, decrease this benefit of aspirin
- taking any other antihistamines
- taking any other drug
When using this product
- drowsiness will occur
- avoid alcoholic drinks
- do not drive a motor vehicle or operate machinery
- take with food or milk if stomach upset occurs
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms heart problems or stroke:
- chest pain
- trouble breathing
- weakness in one part or side of body
- slurred speech
- leg swelling
- pain gets worse or lasts more than 10 days
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness.
- redness or swelling is present in the painful area
- any new symptoms appear
- you have difficulty swallowing
- it feels like the pill is stuck in your throat
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
- do not take more than directed
- drink a full glass of water with each dose
- adults and children 12 years and over: take 2 caplets at bedtime
- do not take more than 2 caplets in 24 hours
- if taken with food, this product may take longer to work
Inactive ingredients
FD&C blue 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide.
Questions?
Call 1-877-770-3183 Mon-Fri 8:00 AM EST to 5:00 PM PST.
— FDA label of Naproxen Sodium and Diphenhydramine HCL, Target Corporation, effective December 19, 2025. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Diphenhydramine hydrochloride 25 mg · Naproxen sodium 220 mg · tablet, film coated (oral) · 15 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Aleve PM | Bayer HealthCare LLC. | DailyMed |
| All Night Pain Relief Pm | Walgreen Company | DailyMed |
| Basic Care Naproxen Sodium Pm | Amazon.com Services LLC | DailyMed |
| Careone Naproxen Sodium Pm | American Sales Company | DailyMed |
| Dg Health Naproxen Sodium Pm | Dolgencorp Inc | DailyMed |
| Equaline Naproxen Sodium Pm | United Natural Foods, Inc. dba UNFI | DailyMed |
| Good Sense Naproxen Sodium | L. Perrigo Company | DailyMed |
| Naproxen Sodium and Diphenhydramine HCl | Amneal Pharmaceuticals NY LLC | DailyMed |
| Naproxen Sodium and Diphenhydramine HCl | Granules India Ltd | — |
| Naproxen Sodium Diphenhydramine HCl | Cvs Pharmacy, Inc | DailyMed |
| Naproxen Sodium Pm | H E B | DailyMed |
| Naproxen Sodium Pm | Meijer Distribution Inc | DailyMed |
| Naproxen Sodium Pm | Safeway | DailyMed |
| Topcare All Night Pain Relief Pm | Topco Associates LLC | DailyMed |
| Up and Up Naproxen Sodium Pm | Target Corporation | DailyMed |
Diphenhydramine hydrochloride 25 mg · Naproxen sodium 220 mg · tablet (oral) · 5 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Naproxen Sodium and Diphenhydramine HCL | Target Corporation | DailyMed |
| Naproxen Sodium Diphenhydramine HCL | Walmart | DailyMed |
| Naproxen Sodium Diphenhydramine Hydrochloride | Safeway | DailyMed |
| Naproxen Sodium Pm | Kroger Company | DailyMed |
| Naproxen Sodium PM | Strategic Sourcing Services LLC | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Target Corporation2 products
- Safeway2 products
- Kroger Company1 product
- L. Perrigo Company1 product
- Bayer HealthCare LLC.1 product
- Walmart1 product
- H E B1 product
- Amneal Pharmaceuticals NY LLC1 product
- Topco Associates LLC1 product
- United Natural Foods, Inc. dba UNFI1 product
- Amazon.com Services LLC1 product
- American Sales Company1 product
- Dolgencorp Inc1 product
- Granules India Ltd1 product
- Walgreen Company1 product
- Strategic Sourcing Services LLC1 product
- Cvs Pharmacy, Inc1 product
- Meijer Distribution Inc1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.