Quick answers
- What is Aspirin, chlorpheniramine and phenylephrine used for?
- The Drug Facts label of Alka-Seltzer Plus Cold Orange Zest (Bayer HealthCare LLC.) lists these uses: · temporarily relieves these symptoms due to a cold: · minor aches and pains · headache · runny nose · nasal and sinus congestion · sneezing · sore throat · temporarily reduces fever.
- Do I need a prescription for Aspirin, chlorpheniramine and phenylephrine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Aspirin, chlorpheniramine and phenylephrine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Alka-Seltzer Plus Cold Orange Zest · Bayer HealthCare LLC.
Aspirin 325 mg · Chlorpheniramine maleate 2 mg · Phenylephrine bitartrate 7.8 mg, tablet, effervescent (oral)
Active ingredient (in each tablet)
Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Phenylephrine bitartrate 7.8 mg *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever/fever reducer Antihistamine Nasal decongestant
Uses
· temporarily relieves these symptoms due to a cold: · minor aches and pains · headache · runny nose · nasal and sinus congestion · sneezing · sore throat · temporarily reduces fever
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
to sedate children.
Do not use
- if you are allergic to aspirin or any other pain reliever/fever reducer
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- if you have ever had an allergic reaction to this product or any of its ingredients
- in children under 12 years of age
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have
- asthma
- diabetes
- thyroid disease
- glaucoma
- difficulty in urination due to enlargement of the prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are · taking a prescription drug for · gout · diabetes · arthritis · taking sedatives or tranquilizers
When using this product
- do not exceed recommended dosage
- excitability may occur, especially in children
- you may get drowsy
- avoid alcoholic drinks
- alcohol, sedatives, and tranquilizers may increase drowsiness
- be careful when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- pain or nasal congestion gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- ringing in the ears or a loss of hearing occurs
- nervousness, dizziness, or sleeplessness occur
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
- adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor.
- children under 12 years: do not use
Other information
- each tablet contains: sodium 476 mg
- Phenylketonurics: Contains Phenylalanine 9 mg Per Tablet
- store at room temperature. Avoid excessive heat.
Inactive ingredients
acesulfame potassium, anhydrous citric acid, aspartame, calcium silicate, dimethicone, docusate sodium, FD&C red #40, FD&C yellow #6, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate
Questions?
1-800-986-0369 (Mon – Fri 9AM – 5PM EST)
— FDA label of Alka-Seltzer Plus Cold Orange Zest, Bayer HealthCare LLC., effective December 4, 2025. See the official label on DailyMed →
Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest · Bayer HealthCare LLC.
Aspirin 325 mg · Chlorpheniramine maleate 2 mg · Phenylephrine bitartrate 7 mg, tablet, effervescent (oral)
Active ingredient (in each tablet)
Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Phenylephrine bitartrate 7.8 mg *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever/fever reducer Antihistamine Nasal decongestant
Uses
Uses · temporarily relieves these symptoms due to a cold: · minor aches and pains · headache · runny nose · nasal and sinus congestion · sneezing · sore throat · temporarily reduces fever
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock Stomach bleeding warning : This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
to sedate children.
Do not use
- if you are allergic to aspirin or any other pain reliever/fever reducer
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- if you have ever had an allergic reaction to this product or any of its ingredients
- in children under 12 years of age
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have
- asthma
- diabetes
- thyroid disease
- glaucoma
- difficulty in urination due to enlargement of the prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are · taking a prescription drug for · gout · diabetes · arthritis · taking sedatives or tranquilizers
When using this product
- do not exceed recommended dosage
- excitability may occur, especially in children
- you may get drowsy
- avoid alcoholic drinks
- alcohol, sedatives, and tranquilizers may increase drowsiness
- be careful when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- pain or nasal congestion gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- ringing in the ears or a loss of hearing occurs
- nervousness, dizziness, or sleeplessness occur
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
Directions
- adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor.
- children under 12 years: do not use
Other information
Other information
- each tablet contains: potassium 80 mg; sodium 356 mg
- store at room temperature. Avoid excessive heat.
Inactive ingredients
Inactive ingredients anhydrous citric acid, calcium silicate, dimethicone, FD&C red #40, FD&C yellow #6, flavor, mannitol, potassium bicarbonate, povidone, sodium bicarbonate, sucralose
Questions?
Questions or comments? 1-800-986-0369 (Mon – Fri 9AM – 5PM EST)
— FDA label of Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest, Bayer HealthCare LLC., effective January 17, 2025. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Aspirin 325 mg · Chlorpheniramine maleate 2 mg · Phenylephrine bitartrate 7.8 mg · tablet, effervescent (oral) · 28 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve | Bayer HealthCare LLC. | DailyMed |
| ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve Orange | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Cold Medicine Sparkling Original | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Cold Orange Zest | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Cold Sparkling Original | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz | Bayer HealthCare LLC. | DailyMed |
| Best Choice Effervescent Cold Relief | Valu Merchandiser Company | DailyMed |
| Dollar General Effervescent Cold Relief | Dolgencorp, LLC | DailyMed |
| Effervescent Cold Relief | Discount Drug Mart | DailyMed |
| Effervescent Cold Relief | Topco Associates LLC | DailyMed |
| Effervescent Orange Cold Relief | CVS Pharmacy, Inc. | DailyMed |
| Effervescent Orange Cold Relief | Dolgencorp, LLC | DailyMed |
| Effervescent Orange Cold Relief | H. E. Butt Grocery Company | DailyMed |
| Effervescent Orange Cold Relief | Meijer Distribution Inc. | DailyMed |
| Equaline Effervescent Cold Relief | United Natural Foods, Inc. dba UNFI | DailyMed |
| Equate Effervescent Cold Relief | Walmart | DailyMed |
| Family Wellness Effervescent Cold Relief Orange | Family Dollar Services, Inc. | DailyMed |
| Good Sense Effervescent Cold Relief | Good Sense | DailyMed |
| Kroger Effervescent Cold Relief | Kroger Company | DailyMed |
| Meijer Effervescent Cold Relief | Meijer Distribution Inc. | DailyMed |
| Quality Choice Effervescent Cold Relief - Orange | Chain Drug Marketing Association | DailyMed |
| Quality Choice Effervescent Cold Relief - Plus | Chain Drug Marketing Association | DailyMed |
| Quality Choice Effervescent Cold Relief Plus | Chain Drug Marketing Association | DailyMed |
| Top Value Effervescent Cold Relief | Tower Laboratories Ltd | DailyMed |
| Top Value Effervescent Cold Relief - Orange | Tower Laboratories Ltd. | DailyMed |
Showing 25 of 27 brands.
Aspirin 325 mg · Chlorpheniramine maleate 2 mg · Phenylephrine bitartrate 7 mg · tablet, effervescent (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Alka-Seltzer Plus Severe Cold PowerFast Fizz Orange Zest | Bayer HealthCare LLC. | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Bayer HealthCare LLC.7 products
- Chain Drug Marketing Association4 products
- Dolgencorp, LLC2 products
- Tower Laboratories Ltd2 products
- Meijer Distribution Inc.2 products
- Walgreens1 product
- Discount Drug Mart1 product
- H. E. Butt Grocery Company1 product
- United Natural Foods, Inc. dba UNFI1 product
- Walmart1 product
- Good Sense1 product
- Family Dollar Services, Inc.1 product
- CVS Pharmacy, Inc.1 product
- Topco Associates LLC1 product
- Valu Merchandiser Company1 product
- Kroger Company1 product
- WinCo Foods, LLC1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.