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Over-the-counter medicine · no prescription needed

Aspirin and caffeine

Purpose on the label: Pain reliever Pain reliever aid

Pain and fever

Official FDA data, not advice

The label text is quoted exactly as the company filed it with the U.S. Food and Drug Administration (FDA), with a link to the official copy. The list of brands comes from the FDA NDC Directory.

This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.

If someone may have taken too much, call Poison Help: 1‑800‑222‑1222. In an emergency, call 911.

Quick answers

What is Aspirin and caffeine used for?
The Drug Facts label of Medi First Pain Ache (Unifirst First Aid Corporation) lists these uses: for the temporary relief of; backache pain; muscle aches and pains; minor aches and pains of arthritis.
Do I need a prescription for Aspirin and caffeine?
No. The products on this page are sold without a prescription (over the counter).
Is a store brand the same as the name brand?
Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
Has Aspirin and caffeine been recalled?
FDA enforcement reports list 1 recall of products on this page; the newest started October 17, 2025. A recall usually concerns specific products or lots, not every brand.

Drug Facts label

Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.

Medi First Pain Ache · Unifirst First Aid Corporation

Aspirin 500 mg · Caffeine 32.5 mg, tablet, film coated (oral)

Active ingredient (in each caplet)

​Aspirin (NSAID)* 500 mg Caffeine 32.5 mg *nonsteroidal anti-inflammatory drug

Purpose

Pain reliever Pain reliever aid

Uses

for the temporary relief of

  • backache pain
  • muscle aches and pains
  • minor aches and pains of arthritis

Warnings

  • Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness.

  • Allergy alert: Aspirin may cause a severe allergic reaction which may include:
  • hives
  • shock
  • facial swelling
  • asthma (wheezing)
  • Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
  • take more or for a longer time than directed
  • take a blood thinning (anticoagulant) or steroid drug
  • are age 60 or older
  • have 3 or more alcohol drinks every day while using this product
  • have had stomach ulcers or bleeding problems
  • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)

Do not use

  • if you are allergic to aspirin or any other pain reliever/fever reducer.
  • if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if

  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have asthma
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic

Ask a doctor or pharmacist before use if

you are taking a prescription drug for

  • gout
  • diabetes
  • arthritis

Stop use and ask a doctor if

  • an allergic reaction occurs. Seek medical help right away.
  • you experience any of the following signs of stomach bleeding:
  • vomit blood
  • have bloody or black stools
  • feel faint
  • have stomach pain that does not get better
  • ringing in the ears or a loss of hearing occurs
  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present
  • new symptoms occur These could be signs of a serious condition.

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless specifically directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

Directions

  • drink a full glass of water with each dose Adults and children (12 years and over): take 2 caplets every 6 hours, not to exceed 8 caplets in 24 hours Children under 12 years: do not use unless directed by a doctor

Other information

  • store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)
  • tamper evident sealed packets
  • do not use any opened or torn packets

Inactive ingredients

corn starch, hypromellose, maltodextrin, microcrystalline cellulose, polyethylene glycol, sodium lauryl sulfate

Questions?

1-800-634-7680

— FDA label of Medi First Pain Ache, Unifirst First Aid Corporation, effective September 9, 2025. See the official label on DailyMed →

Bc Cherry · Medtech Products Inc.

Aspirin 845 mg · Caffeine 65 mg, powder (oral)

Active ingredient (in each powder)

Aspirin (NSAID*) 845 mg *nonsteroidal anti-inflammatory drug Active ingredient (in each powder) Caffeine 65 mg

Purpose

Pain reliever Purpose Pain reliever aid

Uses

temporary relieves minor aches and pains due to: headache backache minor arthritis pain a cold muscle aches toothache menstrual cramps

Warnings

Reye’s syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction which may include: facial swelling asthma (wheezing) shock hives Stomach bleeding warning : This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or non-prescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for longer time than directed

  • Caffeine warning: This product contains caffeine. Limit the use of caffeine-containing medications, foods, or beverages because too much caffeine may cause nervousness, irritability, sleeplessness, andoccasionally, rapid heart beat.

Do not use

if you have ever had an allergic reaction to aspirin or any other pain reliever/fever reducer.

Ask a doctor before use if

stomach bleeding warnings applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma

Ask a doctor or pharmacist before use if

you are taking a prescription drug for diabetes gout arthritis

Stop use and ask a doctor if

an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: ○ feel faint ○ vomit blood ○ have bloody or black stools ○ have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present any new symptoms appear ringing in the ears or a loss of hearing occurs. These could be signs of a serious condition.

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

Directions

A dults and children 12 years of age and over : open 1 pack, place powder on tongue every 6 hours, while symptoms persist. Drink a full glass of water with each dose, or stir powder into a glass of water or other liquid. Do not take more than 4 powders in 24 hours unless directed by a doctor. C hildren under 12 years of age : ask a doctor.

Other information

store below 25ºC (77ºF)

Inactive ingredients

acesulfame potassium, colloidal silicon dioxide, flavor, guar gum, mannitol, microcrystalline cellulose, sucralose

Questions?

1-866-255-5197

— FDA label of Bc Cherry, Medtech Products Inc., effective April 24, 2026. See the official label on DailyMed →

GOODYS Hangover · Medtech Products Inc.

Aspirin 1000 mg · Caffeine 150 mg, powder (oral)

Purpose

Aspirin (NSAID*) 1000 mg…………………………………......Pain reliever Caffeine 150 mg……………………………….…………………Alertness aid *nonsteroidal anti-inflammatory drug

Uses

Temporarily relieves minor aches and pains due to: hangover headache muscle aches Helps restore mental alertness when experiencing fatigue or drowsiness associated with a hangover

Warnings

  • Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy Alert: Aspirin may cause severe allergic reaction which may include:

  • hives
  • facial swelling
  • shock
  • asthma (wheezing).
  • Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
  • are age 60 or older
  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • take other drugs containing prescription or non-prescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed.
  • Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Do not use

  • for more than 2 days for a hangover unless directed by a doctor. Not intended for use as a substitute for sleep. If fatigue or drowsiness persists or continues to recur, consult a doctor.
  • if you have ever had an allergic reaction to aspirin or any other pain reliever/fever reducer
  • in children under 12 years of age

Ask a doctor before use if

  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic
  • you have asthma

Ask a doctor or pharmacist before use if

you are taking a prescription drug for

  • diabetes
  • gout
  • arthritis

Stop use and ask a doctor if

  • an allergic reaction occurs. Seek medical help right away
  • you experience any of the following signs of stomach bleeding
  • feel faint
  • vomit blood
  • have bloody or black stool
  • have stomach pain that does not get better
  • any new symptoms appear
  • ringing in the ears or a loss of hearing occurs These could be signs of a serious condition.

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

Directions

  • Adults and children 12 years and over: open 1 pack, place powder on tongue every 6 hours, while symptoms persist. Drink a full glass of water or other liquid.
  • Do not take more than 4 powders in 24 hours unless directed by a doctor.
  • Children under 12 years: ask a doctor.

Other information

Store below 25°C (77°F)

Inactive ingredients

colloidal silicon dioxide, flavor, guar gum, mannitol, microcrystalline cellulose, sucralose, xylitol.

Questions?

1-866-255-5197 goodyspowder.com

— FDA label of GOODYS Hangover, Medtech Products Inc., effective October 23, 2025. See the official label on DailyMed →

Alka-Seltzer Extra Strength Pain Relief · Bayer HealthCare LLC.

Aspirin 500 mg · Caffeine 65 mg, tablet, effervescent (oral)

Active ingredient (in each tablet)

Aspirin 500 mg (NSAID)* Caffeine 65 mg *nonsteroidal anti-inflammatory drug Pain reliever Alertness aid/pain reliever aid

Purpose

Pain reliever Alertness aid/pain reliever aid

Uses

Uses for temporary relief of headaches, body aches, and pain alone for the temporary relief of minor aches and pains associated with a hangover helps restore mental alertness or wakefulness when experiencing fatigue or drowsiness associated with a hangover

Warnings

Warnings

  • Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

  • Allergy alert: Aspirin may cause a severe allergic reaction which may include:
  • hives
  • facial swelling
  • asthma (wheezing)
  • shock
  • Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
  • are age 60 or older
  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed Caffeine warning : The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine- containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
  • For occasional use only.

Do not use

for more than 2 days for a hangover unless directed by a doctor. Not intended for use as a substitute for sleep. If fatigue or drowsiness persists or continues to recur, consult a doctor. Reye's syndrome Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert Aspirin may cause a severe allergic reaction which may include:

  • hives
  • facial swelling
  • asthma (wheezing)
  • shock Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Caffeine warning The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine- containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
  • For occasional use only.

Do not use

for more than 2 days for a hangover unless directed by a doctor. Not intended for use as a substitute for sleep. If fatigue or drowsiness persists or continues to recur, consult a doctor.

Do not use

if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if

stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma you have a sodium-restricted diet

Ask a doctor or pharmacist before use if

you are taking a prescription drug for

  • diabetes
  • gout
  • arthritis

Stop use and ask a doctor if

an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain lasts for more than 10 days or gets worse redness or swelling is present ringing in the ears or a loss of hearing occurs new symptoms occur

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

Directions

  • fully dissolve 2 tablets in 4 ounces of water before taking
Adults 18 years and over2 tablets every 6 hours as needed, or as directed by a doctordo not exceed 8 tablets in 24 hours
Adults 60 years and over2 tablets every 6 hours as needed, or as directed by a doctordo not exceed 5 tablets in 24 hours
Children under 18 yearsconsult a doctor

Inactive ingredients

anhydrous citric acid, aspartame, dimethicone, docusate sodium, FD&C red No. 40, FD&C yellow No. 6, flavor, mannitol, potassium bicarbonate, povidone, sodium benzoate, sodium bicarbonate, sucralose

Questions?

1-800-986-0369 (Mon – Fri 9AM – 5PM EST)

— FDA label of Alka-Seltzer Extra Strength Pain Relief, Bayer HealthCare LLC., effective February 5, 2026. See the official label on DailyMed →

Bayer Rapid Relief · Bayer HealthCare LLC.

Aspirin 650 mg · Caffeine 65 mg, powder (oral)

Active ingredient (in each tablet)

Aspirin 650 mg (NSAID)* Caffeine 65 mg *nonsteroidal anti-inflammatory drug

Purpose

Pain reliever/fever reducer Pain reliever aid

Uses

temporarily relieves minor aches and pains due to:

  • headache
  • muscle pain
  • backache
  • menstrual cramps
  • minor pain of arthritis
  • temporarily reduces feve

Warnings

Reye’s syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction which may include:

  • hives
  • facial swelling
  • asthma (wheezing)
  • shock Stomach bleeding warning : This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
  • are age 60 or older
  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed

Do not use

  • if you are allergic to aspirin or any other pain reliever/fever reducer
  • if you have ever had an allergic reaction to this product or any of its Ingredients

Ask a doctor before use if

  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic
  • you have asthma

Ask a doctor or pharmacist before use if

you are taking a prescription drug for

  • gout
  • diabetes
  • arthritis

Stop use and ask a doctor if

  • an allergic reaction occurs. Seek medical help right away.
  • you experience any of the following signs of stomach bleeding:
  • feel faint
  • vomit blood
  • have bloody or black stools
  • have stomach pain that does not get better
  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present
  • new symptoms occur
  • ringing in the ears or a loss of hearing occurs

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

adults and children 12 years and over: take contents of 1 powder pack every 6 hours. Dissolve powder on tongue, followed by a full glass of water. Do not exceed 4 powder packs in 24 hours.

  • children under 12 years: consult a doctor

Inactive ingredients

anhydrous citric acid, flavors, mannitol, neotame, sodium citrate monobasic, sucralose

Questions?

1-800-331-4536 (Mon-Fri 9AM - 5PMEST)

— FDA label of Bayer Rapid Relief, Bayer HealthCare LLC., effective December 5, 2025. See the official label on DailyMed →

Aspirina Cafeina · Bayer HealthCare LLC.

Aspirin 500 mg · Caffeine 32.5 mg, tablet (oral)

Active ingredient (in each caplet)

/Principios activos (en cada cápsula) Aspirin 500 mg (NSAID)* Caffeine 32.5 mg *nonsteroidal anti-inflammatory drug Aspirina 500 mg (AINE)* Cafeína 32.5 mg *Fármaco antiinflamatorio no esteroideo

Purpose

/Efecto Pain Reliever Pain reliever aid Analgésico Ayuda analgésica

Uses

/Usos for the temporary relief of headache pain backache pain muscle aches and pains minor aches and pains of arthritis para el alivio temporal de lo siguiente: dolor de cabeza dolor de espalda dolores musculares dolores menores debido a la artritis

Warnings

/Advertencias

  • Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product

if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

  • Allergy alert: Aspirin may cause a severe allergic reaction which may include: hives facial swelling asthma (wheezing) shock
  • Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Síndrome de Reye: Los niños y adolescentes que tienen varicela, o se están recuperando de ella o tienen síntomas parecidos a los de la gripe, no deben usar este producto. Cuando se utiliza este producto, si se producen cambios en la conducta y se presentan náuseas y vómitos, consulte a un médico porque estos síntomas podrían ser un signo temprano del síndrome de Reye, una enfermedad rara pero grave. Alerta de alergia: La aspirina puede provocar una reacción alérgica grave que puede incluir: urticaria edema facial asma (sibilancia) choque Advertencia de sangrado estomacal: Este producto contiene un fármaco antiinflamatorio no esteroideo (AINE), que puede causar una grave hemorragia estomacal. Las posibilidades son mayores si usted tiene 60 años o más ha tenido úlceras estomacales o problemas de sangrado toma un anticoagulante o un medicamento esteroideo toma otros medicamentos que contienen antiinflamatorios no esteroideos (AINE) con o sin receta (aspirina, ibuprofeno, naproxeno u otros) toma 3 o más bebidas alcohólicas todos los días mientras usa este producto

Do not use

/No lo use if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients si es alérgico a la aspirina o a cualquier otro analgésico/antifebril si ha presentado reacciones alérgicas a este producto o a cualquiera de sus componentes

Ask a doctor before use if

/Antes de tomar este producto, consulte a su médico en los siguientes casos stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma si la advertencia de sangrado estomacal se aplica a usted si tiene antecedentes de problemas estomacales, como acidez estomacal si tiene hipertensión arterial, enfermedad cardíaca, cirrosis hepática o enfermedad renal si está tomando diuréticos si tiene asma

Ask a doctor or pharmacist before use if

you are taking a prescription drug for/ Consulte a su médico o a un farmacéutico antes de usar este producto si actualmente está tomando un medicamento de venta con receta para gout diabetes arthritis la gota la diabetes la artritis

Stop use and ask a doctor if

/Suspenda su uso y pregúntele a un médico en los siguientes casos an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding:

  • feel faint
  • vomit blood
  • have bloody or black stools
  • have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present any new symptoms occur ringing in the ears or a loss of hearing occurs si se produce una reacción alérgica. Busque ayuda médica de inmediato. si presenta cualquiera de los siguientes signos de sangrado estomacal:
  • sensación de mareo
  • vómitos de sangre
  • heces negras o con sangre
  • dolor de estómago que no mejora si el dolor empeora o dura más de 10 días si la fiebre empeora o dura más de 3 días si hay enrojecimiento o hinchazón si aparecen nuevos síntomas si tiene zumbido en los oídos o pérdida de la audición Pregnant/Embarazada

If pregnant or breast-feeding

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Si está embarazada o amamantando, consulte a un profesional de la salud antes de usar este producto. En especial, es importante no tomar aspirina al llegar a las 20 semanas o más de embarazo, a menos que su médico le indique claramente que lo haga, porque esto puede provocar problemas en el bebé en gestación o complicaciones durante el parto.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center right away. No dejar al alcance de los niños. En caso de sobredosis, póngase en contacto con un médico o un centro de control de intoxicaciones inmediatamente.

Directions

/Instrucciones drink a full glass of water with each dose adults and children 12 years and over: take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours children under 12 years: consult a doctor beber un vaso de agua lleno con cada dosis adultos y niños mayores de 12 años: tomar 2 cápsulas cada 6 horas sin exceder 8 cápsulas en 24 horas niños menores de 12 años: consultar al médico

Other information

/Otra información save carton for full directions and warnings Store at room temperature. guarde la caja para consultar las instrucciones y advertencias Almacenar a temperatura ambiente

Inactive ingredients

/Principios inactivos carnauba wax, corn starch, D&C red #30 aluminum lake, D&C yellow #10 aluminum lake, hypromellose, powdered cellulose, propylene glycol, shellac, titanium dioxide, triacetin cera de carnauba, almidón de maíz, laca de aluminio D&C rojo #30, laca de aluminio D&C amarillo #10, hipromelosa, celulosa en polvo, propilenglicol, goma laca, dióxido de titanio, triacetina

Questions?

1-800-331-4536 (Mon-Fri 9AM - 5PM EST) ¿Preguntas o comentarios? 1-800-331-4536 (lunes a viernes de 9AM - 5PM EST)

— FDA label of Aspirina Cafeina, Bayer HealthCare LLC., effective June 12, 2025. See the official label on DailyMed →

This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.

Same medicine, other brands

Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.

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Quality Choice Pain Relief Powder Chain Drug Marketing Association DailyMed
Reese Headache Powders Reese Pharmaceutical Co DailyMed
Stanback Medtech Products Inc. DailyMed
Walgreens Pain Relief Powder Walgreens Co. DailyMed
Walmart Pain Relief Powder Walmart DailyMed
Aspirin 1000 mg · Caffeine 150 mg · powder (oral) · 2 products

Drug Facts for this strength and form ↑

Brand or product nameCompany on the labelLabel
GOODYS Hangover Medtech Products Inc. DailyMed
GOODYS Mental Alert Medtech Products Inc. DailyMed
Aspirin 500 mg · Caffeine 65 mg · tablet, effervescent (oral) · 2 products

Drug Facts for this strength and form ↑

Brand or product nameCompany on the labelLabel
Alka-Seltzer Extra Strength Pain Relief Bayer HealthCare LLC. DailyMed
Alka-Seltzer Hangover Relief Bayer HealthCare LLC. DailyMed
Aspirin 650 mg · Caffeine 65 mg · powder (oral) · 2 products

Drug Facts for this strength and form ↑

Brand or product nameCompany on the labelLabel
Bayer Rapid Relief Bayer HealthCare LLC. DailyMed
Bayer Rapid Relief Body Pain Bayer HealthCare LLC. DailyMed
Aspirin 500 mg · Caffeine 32.5 mg · tablet (oral) · 2 products

Drug Facts for this strength and form ↑

Brand or product nameCompany on the labelLabel
Aspirina Cafeina Bayer HealthCare LLC. DailyMed
Bayer Headache Bayer HealthCare LLC. DailyMed
Aspirin 250 mg · Caffeine 65 mg · tablet, film coated (oral) · 1 product
Brand or product nameCompany on the labelLabel
Acetaminophen 250 mg Aspirin 250 mg Caffeine 65 mg Health Pharma USA LLC DailyMed
Aspirin 500 mg/1000 mg · Caffeine 60 mg/1000 mg · tablet, effervescent (oral) · 1 product
Brand or product nameCompany on the labelLabel
Gemma Cut the Cramp Rally Labs LLC DailyMed
Aspirin 400 mg · Caffeine 32 mg · tablet (oral) · 1 product
Brand or product nameCompany on the labelLabel
Anacin Insight Pharmaceuticals LLC DailyMed
Aspirin 845 mg/1.2 g · Caffeine 65 mg/1.2 g · powder (oral) · 1 product
Brand or product nameCompany on the labelLabel
Cafiaspirina Rapid Headache Relief Belmora LLC DailyMed
Aspirin 500 mg · Caffeine 35.5 mg · tablet (oral) · 1 product
Brand or product nameCompany on the labelLabel
Bayer Back and Body Extra Strength Bayer HealthCare LLC. DailyMed
Aspirin 1000 mg · Caffeine 65 mg · powder (oral) · 1 product
Brand or product nameCompany on the labelLabel
BC Arthritis Medtech Products Inc. DailyMed
Aspirin 500 mg · Caffeine 60 mg · tablet, effervescent (oral) · 1 product
Brand or product nameCompany on the labelLabel
Blowfish Rally Labs LLC DailyMed

What pharmacies pay (NADAC)

The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.

This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.

NADAC per unit for Aspirin and caffeine, by strength and form
Strength and formGeneric or brandPharmacies pay
aspirin 500 mg · caffeine 32.5 mg
tablet, film coated
Generic $0.0425 per tablet

NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.

Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →

Companies that sell this medicine

The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.

  • Bayer HealthCare LLC.7 products
  • Medtech Products Inc.6 products
  • Unifirst First Aid Corporation3 products
  • Dolgencorp, LLC2 products
  • Rally Labs LLC2 products
  • Health Pharma USA LLC1 product
  • Meijer Distribution Inc1 product
  • WinCo Foods, LLC1 product
  • Cardinal Health 110, LLC. DBA Leader1 product
  • Insight Pharmaceuticals LLC1 product
  • L.N.K. International, Inc.1 product
  • Reese Pharmaceutical Co1 product
  • Belmora LLC1 product
  • Family Dollar Services Inc1 product
  • Chain Drug Marketing Association1 product
  • Value Merch1 product
  • Lil' Drug Store Products, Inc1 product
  • Walgreens Co.1 product
  • Rite Aid Corporation1 product
  • Aero Healthcare1 product
  • Thompson Safety1 product
  • Walmart1 product
  • Kroger Company1 product
  • CVS Pharmacy1 product

Recalls

From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific products or lots: check the name and lot number on your package.

  1. October 17, 2025 · Class II · Ongoing · D-0155-2026

    Labeling: Label Mix-up. This issue affects the outer box labeling only. The box incorrectly states the ingredients Acetaminophen 500mg and Caffeine 65mg. The inner pouch correctly states the ingredients are Aspirin (NSAID)*500mg and Caffeine 32.5mg.

    Acetaminophen 500mg Caffeine 65mg caplets, packaged as 2 caplets per packet further packaged in a 50-count box, AERO TAB, Manufactured for AERO HEALTHCARE US, Valley-Cottage, NY, 10989, NDC 55305-135-01 — Aero Healthcare

Sources

  1. Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
  2. NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
  3. Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
  4. FDA rule for the Drug Facts label (21 CFR 201.66)

Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.

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