Quick answers
- What is Anhydrous citric acid, aspirin and sodium bicarbonate used for?
- The Drug Facts label of Rite Aid Antacid and Pain Relief (Rite Aid) lists these uses: Uses for the temporary relief of; heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains; upset stomach with headache from overindulgence in food or drink; headache, body aches, and pain alone.
- Do I need a prescription for Anhydrous citric acid, aspirin and sodium bicarbonate?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Anhydrous citric acid, aspirin and sodium bicarbonate been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Rite Aid Antacid and Pain Relief · Rite Aid
Anhydrous citric acid 1000 mg · Aspirin 325 mg · Sodium bicarbonate 1916 mg, tablet, effervescent (oral)
Active ingredient (in each effervescent tablet)
Anhydrous citric acid 1000 mg Aspirin 325 mg (NSAID)* Sodium bicarbonate (heat-treated) 1916 mg *Nonsteroidal anti-inflammatory drug
Purpose
Anhydrous citric acid 1000 mg. . . . . . . . . . . . . . . . . Antacid Aspirin 325 mg (NSAID)* . . . . . . . . . . . . . . . . . . . . . Pain reliever Sodium bicarbonate (heat-treated) 1916 mg. . . . . . Antacid *Nonsteroidal anti-inflammatory drug
Uses
Uses for the temporary relief of
- heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains
- upset stomach with headache from overindulgence in food or drink
- headache, body aches, and pain alone
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
Do not use
Do not use
- if you are allergic to aspirin or any other pain reliever/fever reducer
- if you have ever had an allergic reaction to this product or any of its ingredients.
Ask a doctor before use if
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
- you have a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are
- presently taking a prescription drug. Antacids may interact with certain prescription drugs.
- taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis
When using this product
When using this product
do not take more than 8 tablets (adults) or 4 tablets (60 years and over) in a 24-hour period or use the maximum dosage for more than 2 weeks, except under the advice and supervision of a physician.
Stop use and ask a doctor if
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- an allergic reaction occurs. Seek medical help right away.
- pain lasts for more than 10 days or gets worse
- new symptoms occur
- redness or swelling is present
- ringing in the ears or a loss of hearing occurs
If pregnant or breast-feeding
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
Keep out of reach of children
Directions
- do not exceed recommended dosage
- to avoid serious injury, completely dissolve tablets in 4 oz. of water before taking adults and children 12 years and over (up to 60 years of age): 2 tablets every 4 hours - do not exceed 8 tablets in 24 hours 60 years and over: 2 tablets every 4 hours - do not exceed 4 tablets in 24 hours Children under 12 years - consult a doctor
Other information
- each tablet contains: sodium 524 mg
- store at room temperature (59º-86ºF)
Inactive ingredients
■ none
— FDA label of Rite Aid Antacid and Pain Relief, Rite Aid, effective December 11, 2024. See the official label on DailyMed →
Leader Extra Strength Effervescent Antacid and Pain Reliever · Cardinal Health
Anhydrous citric acid 1000 mg · Aspirin 500 mg · Sodium bicarbonate 1985 mg, tablet, effervescent (oral)
Active ingredient (in each effervescent tablet)
Anhydrous citric acid 1000 mg Aspirin 500 mg (NSAID) * Sodium bicarbonate (heat-treated) 1985 mg *Nonsteroidal anti-inflammatory drug
Purpose
(in each effervescent tablet) Anhydrous citric acid 1000 mg..............................................................Antacid Aspirin 500 mg (NSAID) *......................................................................Pain Reliever Sodium bicarbonate (heat-treated) 1985 mg........................................Antacid *Nonsteroidal anti-inflammatory drug
Uses
Uses for the temporary relief of
- heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains
- upset stomach with headache from overindulgence in food or drink
- headache, body aches and pain alone
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
Do not use
- if you are allergic to aspirin or any other pain reliever/fever reducer
- if you have ever had an allergic reaction to this product or any of its ingredients.
Ask a doctor before use if
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
- you have a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are
- presently taking a prescription drug. Antacids may interact with certain prescription drugs.
- taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis
When using this product
When using this product
do not take more than 8 tablets (adults) or 4 tablets (60 years and over) in a 24-hour period or use the maximum dosage for more than 2 weeks, except under the advice and supervision of a physician.
Stop use and ask a doctor if
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- an allergic reaction occurs. Seek medical help right away.
- pain lasts for more than 10 days or gets worse
- new symptoms occur
- redness or swelling is present
- ringing in the ears or a loss of hearing occurs
If pregnant or breast-feeding
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
Directions
- do not exceed recommended dosage
- to avoid serious injury, completely dissolve tablets in 4 oz. of water before taking adults and children 12 years and over (up to 60 years of age): 2 tablets every 4 hours - do not exceed 8 tablets in 24 hours 60 years and over: 2 tablets every 4 hours - do not exceed 4 tablets in 24 hours Children under 12 years: consult a doctor
Other information
- each tablet contains: sodium 575 mg
- store at room temperature (59º-86ºF)
Inactive ingredients
flavor
Questions?
1-888-228-6937
— FDA label of Leader Extra Strength Effervescent Antacid and Pain Reliever, Cardinal Health, effective February 25, 2026. See the official label on DailyMed →
Alka-Seltzer Extra Strength · Bayer HealthCare LLC.
Anhydrous citric acid 1000 mg · Aspirin 500 mg · Sodium bicarbonate 1985 mg, granule, effervescent (oral)
Active ingredient (in each tablet)
Purpose Anhydrous citric acid 1000 mg Antacid Aspirin 500 mg Analgesic Sodium bicarbonate (heat-treated) 1985 mg Antacid
Purpose
Active ingredients (in each tablet) Purpose Anhydrous citric acid 1000 mg Antacid Aspirin 500 mg Analgesic Sodium bicarbonate (heat-treated) 1985 mg Antacid
Uses
for the temporary relief of: heartburn, acid indigestion, and sour stomach when accompanied with headache or body aches and pains upset stomach with headache from overindulgence in food or drink headache, body aches, and pain alone
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include hives facial swelling asthma (wheezing) shock
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed
Do not use
if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma you have a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are presently taking a prescription drug. Antacids may interact with certain prescription drugs. taking a prescription drug for anticoagulation (blood thinning), diabetes, gout, or arthritis
When using this product
do not exceed recommended dosage
Stop use and ask a doctor if
an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better symptoms get worse or last more than 10 days redness or swelling is present ringing in the ears or a loss of hearing occurs new symptoms occur
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
fully dissolve 2 tablets in 4 ounces of water before taking
| adults and children 12 years and over | 2 tablets every 6 hours, or as directed by a doctor | do not exceed 7 tablets in 24 hours |
| adults 60 years and over | 2 tablets every 6 hours, or as directed by a doctor | do not exceed 3 tablets in 24 hours |
| children under 12 years | consult a doctor | |
Inactive ingredients
flavor
Questions?
1-800-986-0369 (Mon - Fri 9AM - 5PM EST)
— FDA label of Alka-Seltzer Extra Strength, Bayer HealthCare LLC., effective December 4, 2025. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Anhydrous citric acid 1000 mg · Aspirin 325 mg · Sodium bicarbonate 1916 mg · tablet, effervescent (oral) · 28 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Alka-Seltzer Heartburn and Pain | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Original | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Original | R J General Corporation | DailyMed |
| Alka-Seltzer Original | Select Consumer Group | DailyMed |
| Best Choice Effervescent Antacid Pain Relief | Valu Merchandisers Company | DailyMed |
| Bromo Seltzer | Tower Laboratories Ltd | DailyMed |
| Care One Original Antacid and Pain Relief | Foodhold U.S.A. | DailyMed |
| CVS Effervescent Antacid and Pain Reliever | CVS Pharmacy | — |
| DG Health Effervescent Antacid and Pain Relief | Dolgencorp, Inc | DailyMed |
| Drug Mart Effervescent Pain Relief | Discount Drug Mart, Inc | DailyMed |
| Effervescent Antacid and Pain Relief | H. E. Butt Grocery Company | DailyMed |
| Equaline Effervescent Antacid and Pain Relief | United Natural Foods, Inc. dba UNFI | DailyMed |
| Equate Effervescent Antacid and Pain Relief | Walmart | DailyMed |
| Good Sense Effervescent Antacid and Pain Relief | Good Sense | DailyMed |
| Kroger Effervescent Antacid and Pain Relief | Kroger Company | DailyMed |
| Market Basket Effervescent Antacid and Pain Relief | Demoulas Super Markets, Inc. | DailyMed |
| Meijer Effervescent Antacid and Pain Relief | Meijer Distribution Inc | DailyMed |
| Publix Fast Relief Effervescent | Publix Super Markets Inc. | DailyMed |
| Quality Choice Effervescent Antacid and Pain Relief | Chain Drug Marketing Association | DailyMed |
| Quality Choice Effervescent Antacid and Pain Relief | Chain Drug Marketing Association, Inc. | — |
| Rite Aid Antacid and Pain Relief | Rite Aid | DailyMed |
| Signature Care Effervescent Antacid and Pain Relief | Safeway, Inc | DailyMed |
| Top Value Effervescent Pain Relief | Tower Laboratories Ltd | DailyMed |
| TopCare Effervescent Antacid and Pain Relief | Topco Associates LLC | DailyMed |
| Up and Up Antacid and Pain Relief | Target Corporation | DailyMed |
Showing 25 of 27 brands.
Anhydrous citric acid 1000 mg · Aspirin 500 mg · Sodium bicarbonate 1985 mg · tablet, effervescent (oral) · 6 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| CVS Health Extra Strength Antacid and Pain Reliever | CVS Pharmacy | DailyMed |
| HEB Extra Strength Effervescent Antacid and Pain Relief | H. E. Butt Grocery Company | DailyMed |
| Leader Extra Strength Effervescent Antacid and Pain Reliever | Cardinal Health | DailyMed |
| Quality Choice Effervescent Antacid and Pain Relief - Extra Strength | Chain Drug Marketing Association | DailyMed |
| Quality Choice Extra Strength Effervescent Antacid and Pain Relief | Chain Drug Marketing Association | DailyMed |
| Walgreens Antacid Pain Relief Extra Strength | Walgreens | DailyMed |
Anhydrous citric acid 1000 mg · Aspirin 500 mg · Sodium bicarbonate 1985 mg · granule, effervescent (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Alka-Seltzer Extra Strength | Bayer HealthCare LLC. | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Bayer HealthCare LLC.3 products
- Chain Drug Marketing Association3 products
- Tower Laboratories Ltd3 products
- Walgreens2 products
- CVS Pharmacy2 products
- H. E. Butt Grocery Company2 products
- Foodhold U.S.A.1 product
- Discount Drug Mart, Inc1 product
- Cardinal Health1 product
- R J General Corporation1 product
- Safeway, Inc1 product
- Good Sense1 product
- Publix Super Markets Inc.1 product
- Rite Aid1 product
- Kroger Company1 product
- Meijer Distribution Inc1 product
- Demoulas Super Markets, Inc.1 product
- Chain Drug Marketing Association, Inc.1 product
- Select Consumer Group1 product
- Target Corporation1 product
- Topco Associates LLC1 product
- Valu Merchandisers Company1 product
- United Natural Foods, Inc. dba UNFI1 product
- Walmart1 product
- Dolgencorp, Inc1 product
- WinCo Foods, LLC1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.