Quick answers
- What is Etonogestrel and ethinyl estradiol used for?
- The FDA-approved label (NuvaRing, Organon LLC, November 14, 2025) says: “FOR VAGINAL USE ONLY NuvaRing ® is indicated for use by females of reproductive age to prevent pregnancy. NuvaRing is an estrogen/progestin combination hormonal contraceptive (CHC) indicated for use by women to prevent pregnancy.” This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
- Does Etonogestrel and ethinyl estradiol have a boxed warning?
- Yes. The FDA label for NuvaRing has a boxed warning (“WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS”), the FDA’s strongest warning. Read it on the full label and ask your pharmacist.
- Is there a shortage of Etonogestrel and ethinyl estradiol?
- No current shortage is listed by the FDA for the products of this medicine (FDA data from October 30, 2026).
- Has Etonogestrel and ethinyl estradiol been recalled?
- No recall linked to the products of this medicine appears in the FDA enforcement reports we use.
- Who makes Etonogestrel and ethinyl estradiol?
- 9 companies list prescription products of Etonogestrel and ethinyl estradiol in the FDA NDC Directory, including A-S Medication Solutions, NorthStar Rx LLC and AvKARE.
What Etonogestrel and ethinyl estradiol is used for
Quoted from the “Indications and Usage” section of the FDA-approved label.
FOR VAGINAL USE ONLY NuvaRing ® is indicated for use by females of reproductive age to prevent pregnancy. NuvaRing is an estrogen/progestin combination hormonal contraceptive (CHC) indicated for use by women to prevent pregnancy.
— FDA label: NuvaRing, Organon LLC, effective November 14, 2025. Read the full label on DailyMed →
The FDA has 11 labels for products of this medicine (different makers and forms); uses can differ between them. Check the label that comes with your own medicine.
This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
Boxed warning
A boxed warning (“black box”) is the FDA’s strongest warning on a drug label, for serious or life-threatening risks.
This label has a boxed warning. Its heading: WARNING: CIGARETTE SMOKING AND SERIOUS CARDIOVASCULAR EVENTS
. Read it on the full label →
11 of 11 FDA labels for this medicine have a boxed warning.
Forms and how it is given
| Dosage forms | Insert, extended release · Ring |
|---|---|
| Route | Vaginal |
| Prescription products | 11 in the FDA NDC Directory |
| Brand names | Nuvaring, Enilloring, Eluryng |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| ethinyl estradiol 0.015 mg/d · etonogestrel 0.12 mg/d insert, extended release | Generic | $45.07 per unit |
| ethinyl estradiol 0.015 mg/d · etonogestrel 0.12 mg/d insert, extended release | Brand: NuvaRing | $155.70 per unit |
| ethinyl estradiol 0.015 mg/d · etonogestrel 0.12 mg/d ring | Generic | $45.07 per unit |
NADAC list of November 4, 2026; these prices took effect between July 22, 2026 and October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that list this medicine
Labelers in the FDA NDC Directory: the company named on the package (maker or distributor), with the number of prescription products.
- A-S Medication Solutions3 products
- NorthStar Rx LLC1 product
- AvKARE1 product
- Xiromed, LLC1 product
- Teva Pharmaceuticals USA, Inc.1 product
- Prasco Laboratories1 product
- Amneal Pharmaceuticals LLC1 product
- Advanz Pharma (US) Corp.1 product
- Organon LLC1 product
FDA approval history
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
- ANDA: Abbreviated New Drug Application: how a generic version is approved.
| Application | Sponsor | Approved | Later changes approved |
|---|---|---|---|
| NDA021187 NUVARING | Organon USA Organon | October 3, 2001 | 26, latest May 31, 2024 2024: Labeling · 2022: Labeling · 2019: Labeling |
Generic approvals (3)
- ANDA210830Amneal · December 11, 2019
- ANDA204305Teva Pharms USA Inc · January 13, 2021
- ANDA211157Xiromed · June 29, 2023
Shortage status
The FDA drug shortage list does not show these products.
Recalls
No recall linked to these products (by their NDC code) appears in the FDA enforcement reports.
Official identifiers
| RxCUI (RxNorm) | 1367436, 1367439, 2266506, 2644707 |
|---|---|
| SPL set ID of the quoted label | 55eb60e3-6f4d-40a3-8ee6-e7fd2d0c7d97 |
| FDA labels (SPL) | 11 |
| FDA applications | NDA021187, 3 ANDA |
| Active ingredients (FDA) | ETHINYL ESTRADIOL / ETONOGESTREL |
Sources
- FDA-approved label on DailyMed (National Library of Medicine) — NuvaRing, Organon LLC, effective November 14, 2025; via openFDA, FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- Drug shortages (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
openFDA data is provided by the FDA as is; it may be incomplete. Always rely on the label that comes with your medicine. FDA Enforcement Report search →