Quick answers
- What is Marcaine?
- Marcaine is a brand name of Bupivacaine hydrochloride and Bupivacaine hydrochloride and epinephrine bitartrate, a prescription medicine. The FDA NDC Directory lists 10 Marcaine products in 9 strengths and forms.
- Who makes Marcaine?
- Hospira holds the FDA application for Marcaine (NDA016964, approved October 3, 1972). 2 other companies (repackagers or distributors) also list Marcaine products.
- Is there a generic or store brand of Marcaine?
- Yes. The FDA NDC Directory lists 77 other products with the same active ingredients, strength and form as a Marcaine product, 70 of them generic. Ask your pharmacist whether one is right for you.
- Has Marcaine been recalled?
- No recall linked to Marcaine products (by their NDC code or label) appears in the FDA enforcement reports we use.
What Marcaine is
Each Marcaine product as listed in the FDA NDC Directory, by active ingredient, strength and form, with its official label. “Same medicine, other names” counts the other products with exactly the same active ingredients, strength and form (generic versions, store brands and other brands); inactive ingredients can differ.
Bupivacaine hydrochloride · prescription medicine
| Strength and form | Product names | Same medicine, other names | Label |
|---|---|---|---|
| bupivacaine hydrochloride 150 mg/30 mL injection, solution (epidural, intracaudal, perineural) | Marcaine | None listed | — |
| bupivacaine hydrochloride 2.5 mg/mL injection, solution (epidural, infiltration, intracaudal, perineural) | Marcaine | 38 products, 20 companies | DailyMed |
| bupivacaine hydrochloride 225 mg/30 mL injection, solution (epidural, retrobulbar) | Marcaine | None listed | — |
| bupivacaine hydrochloride 25 mg/10 mL injection, solution (epidural, infiltration, intracaudal, perineural) | Marcaine | None listed | — |
| bupivacaine hydrochloride 250 mg/50 mL injection, solution (perineural) | Marcaine | None listed | — |
| bupivacaine hydrochloride 5 mg/mL injection, solution (epidural, intracaudal, perineural) | Marcaine | 38 products, 20 companies | DailyMed |
| bupivacaine hydrochloride 50 mg/10 mL injection, solution (epidural, intracaudal, perineural) | Marcaine | None listed | — |
| bupivacaine hydrochloride 75 mg/30 mL injection, solution (epidural, infiltration, intracaudal, perineural) | Marcaine | None listed | — |
Its page lists every product and company, the FDA label’s uses and boxed warning, approvals, shortages and recalls: Bupivacaine hydrochloride →
Bupivacaine hydrochloride and epinephrine bitartrate · prescription medicine
| Strength and form | Product names | Same medicine, other names | Label |
|---|---|---|---|
| bupivacaine hydrochloride anhydrous 5 mg/mL · epinephrine bitartrate 0.005 mg/mL injection, solution (submucosal) | Marcaine | 1 product, 1 company | DailyMed |
Its page lists every product and company, the FDA label’s uses and boxed warning, approvals, shortages and recalls: Bupivacaine hydrochloride and epinephrine bitartrate →
FDA approval
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
- ANDA: Abbreviated New Drug Application: how a generic version is approved.
| Application | Holder | First approved | Products |
|---|---|---|---|
| NDA016964 | Hospira | October 3, 1972 | 9 |
| ANDA077250 | Septodont | September 27, 2006 | 1 |
Companies that list Marcaine
The company named on the package (holder, repackager or distributor), as listed in the FDA NDC Directory, with its number of Marcaine products.
- Hospira, Inc.6 products
- Henry Schein, Inc.3 products
- Septodont, Inc.1 product
Recalls
No recall linked to Marcaine products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- NADAC (National Average Drug Acquisition Cost) 2026 — Centers for Medicare & Medicaid Services (CMS), data.medicaid.gov, list of November 4, 2026, retrieved November 7, 2026
Which names get a brand page: a name the NDC Directory lists for a medicine, held by one company (the FDA application holder, or the company named on most of its products), that is not just a description, and that is not the only product of its medicine.