Quick answers
- What is Neomycin, polymyxin b and pramoxine used for?
- The Drug Facts label of Signature Care First Aid Antibiotic (Safeway) lists these uses: first aid to help prevent infection and for temporary relief of pain or discomfort in minor; cuts; scrapes; burns.
- Do I need a prescription for Neomycin, polymyxin b and pramoxine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Neomycin, polymyxin b and pramoxine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Signature Care First Aid Antibiotic · Safeway
Neomycin sulfate 0.35% · Polymyxin b sulfate 10000 [USP'U]/g · Pramoxine hydrochloride 1%, cream (topical)
Active ingredient (in each gram)
Neomycin sulfate equivalent to 3.5 mg of neomycin base Polymyxin B 10,000 units as polymyxin B sulfate Pramoxine HCl 10 mg
Purpose
First aid antibiotic External analgesic
Uses
first aid to help prevent infection and for temporary relief of pain or discomfort in minor:
- cuts
- scrapes
- burns
Warnings
For external use only.
Do not use
- if you are allergic to any of the ingredients
- in the eyes
- over large areas of the body
Ask a doctor before use if
you have
- deep or puncture wounds
- animal bites
- serious burns
Stop use and ask a doctor if
- you need to use longer than 1 week
- condition persists or gets worse
- symptoms persist for more than 1 week, or clear up and occur again within a few days
- rash or other allergic reaction develops
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
Directions
- adults and children 2 years of age or older:
- clean the affected area
- apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area 1 to 3 times daily
- may be covered with a sterile bandage
- children under 2 years of age: ask a doctor
Inactive ingredients
emulsifying wax, methylparaben, mineral oil, poloxamer 188, propylene glycol, purified water, white petrolatum
Questions?
1-888-723-3929
— FDA label of Signature Care First Aid Antibiotic, Safeway, effective September 26, 2024. See the official label on DailyMed →
Publix antibiotic plus Pain Relief · Publix Super Markets Inc
Neomycin sulfate 0.35% · Polymyxin b sulfate 10000 [iU]/g · Pramoxine hydrochloride 1%, cream (topical)
Active ingredient (each gram contains)
Purpose Neomycin sulfate 3.5 mg First aid antibiotic Polymyxin B sulfate 10,000 units First aid antibiotic Pramoxine hydrochloride 10 mg Topical analgesic
Purpose
Active ingredients (each gram contains) Purpose Neomycin sulfate 3.5 mg First aid antibiotic Polymyxin B sulfate 10,000 units First aid antibiotic Pramoxine hydrochloride 10 mg Topical analgesic
Uses
first aid to help prevent infection and for the temporary relief of pain or discomfort in minor cuts scrapes burns
Warnings
For external use only
Do not use
in the eyes over large areas of the body if you are allergic to any of the ingredients longer than 1 week Ask a doctor before use on deep or puncture wounds, animal bites, or serious burns
Stop use and ask a doctor if
condition gets worse condition persists for more than 7 days condition clears up and occurs again within a few days a rash or other allergic reaction develops
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
Adults and children 2 years of age and older: clean the affected area and dry thoroughly apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area 1 to 3 times daily may be covered with a sterile bandage Children under 2 years of age: consult a doctor
Inactive ingredients
emulsifying wax, methylparaben, mineral oil, propylene glycol, purified water, white petrolatum
— FDA label of Publix antibiotic plus Pain Relief, Publix Super Markets Inc, effective July 15, 2025. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Neomycin sulfate 0.35% · Polymyxin b sulfate 10000 [USP'U]/g · Pramoxine hydrochloride 1% · cream (topical) · 17 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Antibiotic | H E B | DailyMed |
| Antibiotic and Pain Relief | CVS Pharmacy | DailyMed |
| Antibiotic and Pain Relief | Strategic Sourcing Services LLC | DailyMed |
| Antibiotic and Pain Relief | Target Corporation | DailyMed |
| Antibiotic Plus Pain Relief | Kroger Company | DailyMed |
| DG Health Antibiotic | Dolgencorp Inc | DailyMed |
| Dual Action Cream | Trifecta Pharmaceutical USA LLC | DailyMed |
| Equate Antibiotic Plus Pain Relief | WalMart | DailyMed |
| Family Care Antibiotic Pain Relief 0.33oz | United Exchange Corp | DailyMed |
| First Aid Antibiotic and Pain Relief | Meijer, Inc. | DailyMed |
| Good Neighbor Pharmacy Antibiotic and Pain Relief | Amerisource Bergen | DailyMed |
| Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving | Kenvue Brands LLC | DailyMed |
| Premier Value Max Strength Antibiotic plus pain relief | Pharmacy Value Alliance LLC | DailyMed |
| Signature Care First Aid Antibiotic | Safeway | DailyMed |
| Topcare Antibiotic | Topco Associates LLC | DailyMed |
| Walgreens Kids Multi-Antibiotic with Pain Relief Cream | Walgreens Company | DailyMed |
| Walgreens Multi-Antibiotic with Pain Relief Cream | Walgreens Company | DailyMed |
Neomycin sulfate 0.35% · Polymyxin b sulfate 10000 [iU]/g · Pramoxine hydrochloride 1% · cream (topical) · 4 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Antibiotic Plus Pain Relief | TARGET Corporation | DailyMed |
| Neosporin Kids Plus Pain Relief | Kenvue Brands LLC | DailyMed |
| Publix antibiotic plus Pain Relief | Publix Super Markets Inc | DailyMed |
| TopCare Antibiotic Plus Pain Relief | Topco Associates LLC | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| neomycin sulfate 0.35% · polymyxin b sulfate 10000 USP units/g · pramoxine hydrochloride 1% cream | Generic | $0.0949–$0.1887 per gram 2 packages, lowest to highest |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Kenvue Brands LLC2 products
- TARGET Corporation2 products
- Walgreens Company2 products
- Topco Associates LLC2 products
- Trifecta Pharmaceutical USA LLC1 product
- Safeway1 product
- United Exchange Corp1 product
- Strategic Sourcing Services LLC1 product
- CVS Pharmacy1 product
- H E B1 product
- Publix Super Markets Inc1 product
- Dolgencorp Inc1 product
- Kroger Company1 product
- Pharmacy Value Alliance LLC1 product
- Meijer, Inc.1 product
- Amerisource Bergen1 product
- WalMart1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.