Quick answers
- What is Histamine used for?
- The Drug Facts label of Pain Relieving Cream (Mediapower, Inc. DBA Dr Newton's and Naturals) lists these uses: for the temporary relief of minor aches and pains of muscles and joints associated with; simple backache; arthritis; strains; bruises; sprains.
- Do I need a prescription for Histamine?
- No, the products on this page are sold without a prescription. Other products with the same active ingredient need a prescription (often a higher strength or another form): see the prescription page.
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredient, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Histamine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Also sold by prescription (often at a higher strength or in another form): Histamine — prescription medicine
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Pain Relieving Cream · Mediapower, Inc. DBA Dr Newton's and Naturals
Histamine dihydrochloride 0.05%, cream (topical)
Active ingredient
Histamine dihydrochloride 0.05% w/w
Purpose
Pain reliever
Uses
for the temporary relief of minor aches and pains of muscles and joints associated with
- simple backache
- arthritis
- strains
- bruises
- sprains
Warnings
For external use only
Do not use
- on wounds or damaged skin
- if you are allergic to ingredients in this product
When using this product
- avoid contact with the eyes. If product gets into the eyes, rinse thoroughly with water
- do not bandage tightly or use a heating pad
Stop use and ask a doctor if
- rash appears
- condition worsens, or if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days
If pregnant or breastfeeding
ask a health professional before use.
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
- adults and children 12 years of age and older: Apply to affected area not more than 3 to 4 times daily
- children under 12 years of age: do not use, consult a physician
Inactive ingredients
Water, Cetearyl alcohol, Emu oil, Glycerin, Ceteareth-20, Glucosamine sulfate, Dimethyl sulfone, Caprylic/capric triglyceride, Phenoxyethanol, Cetyl alcohol, Tocopherol acetate, Butylene glycol, Propylene glycol, Chamomile ( Chamomilla recutita ) flower extract, Rosemary ( Rosemarinus officinalis ) leaf extract, Indian frankincense ( Boswellia serrata ) extract, Ethylhexylglycerin.
Questions?
+1-866-788-5951 You may also report serious side effects to this phone number. Mon-Fri 8:00 A.M. - 6:00 P.M.
— FDA label of Pain Relieving Cream, Mediapower, Inc. DBA Dr Newton's and Naturals, effective February 19, 2025. See the official label on DailyMed →
Bakers Best Arthritis Pain Relief · Baker's Best Health Products, LLC
Histamine dihydrochloride 0.03%, cream (topical)
Active ingredient
Histamine DHCl (0.03%) Topical Analgesic
Purpose
Topical Analgesic
Uses
For the temporary relief of minor aches and pains of the muscles and joints associated with arthritis, simple backache, sprains, bruises and strains.
Warnings
For external use only.
- Avoid contact with eyes.
- If symptoms persist for more than seven days, discontinue use and consult physician.
Keep out of reach of children
If swallowed, consult physician. Do not apply to wounds or damaged skin. Do not bandage tightly. If pregnant or breast feeding, contact physician prior to use.
Directions
- Adults and children two-years of age or older: Apply to affected area not more than three to four times daily.
- Children under two-years of age: consult a physician.
Inactive ingredients
Other Ingredients: Aloe Barbadensis Leaf (Aloe Vera Gel) Juice, Aqua (Deionized Water), Arnica Montana Extract, Boswellia Serrata Extract, Caprylic/Capric Triglyceride, Cetearyl Olivate, Glucosamine Sulfate, Glycerin, Glyceryl Caprylate, Glyceryl Stearate, Glyceryl Undecylenate, Ilex Paraguariensis (Yerba Mate’) Extract, Magnesium Sulfate, Methylsulfonylmethane (MSM), Sodium Polyacrylate, Sorbitan Olivate, Stearic Acid, Xanthan Gum, Zemea (Corn) Propanediol.
— FDA label of Bakers Best Arthritis Pain Relief, Baker's Best Health Products, LLC, effective January 19, 2026. See the official label on DailyMed →
Arthritis Pain Relief Cream · Sombra Cosmetics Inc.
Histamine dihydrochloride 0.025%, cream (topical)
Active ingredient
Histamine Dihydrochloride .025%
Purpose
External Analgesic
Uses
Section For use by adults and children over 12 years. Apply a thin layer to pain site and massage until thoroughly absorbed into skin. Apply no more than 3 to 4 times daily. Children 12 years or younger consult a physician.
Warnings
Section For external use only.
Do not use
on wounds or damaged skin or if you are allergic to ingredients in the product.
When using this product
avoid contact with eyes. If product gets into eyes, rinse thoroughly with water. Do not bandage tightly or use a heating pad. Stop use and ask doctor if: rash appears. condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days. Uses For the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backaches, strains & bruises. Directions For use by adults and children over 12 years. Apply a thin layer to pain site and massage until thoroughly absorbed into skin. Apply no more than 3 to 4 times daily. Children 12 years or younger consult a physician. Warnings For external use only.
Do not use
on wounds or damaged skin or if you are allergic to ingredients in the product.
When using this product
avoid contact with eyes. If product gets into eyes, rinse thoroughly with water. Do not bandage tightly or use a heating pad. Stop use and ask doctor if: rash appears. condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days.
Keep out of reach of children
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away
Directions
Apply no more than 3 to 4 times daily.
Inactive ingredients
Aqua (Purified Water), Butylene Glycol, Emu Oil, Ethylhexylglycerin, Ethylhexyl Stearate, Helianthus Annuus (Sunflower) Seed Oil, C13-14 Isoparaffin, Laureth-7, Methylsulfonylmethane (MSM), Polyacrylamide, Potassium Sorbate, Sodium Polyacrylate, Tetrasodium EDTA, Tochopheryl Acetate (Vitamin E), Trideceth-6, Chondroitin Sulfate, Glucosamine Sulfate
Questions?
Call 1-888-600-4642
— FDA label of Arthritis Pain Relief Cream, Sombra Cosmetics Inc., effective May 21, 2026. See the official label on DailyMed →
AMINO ACTIVE Topical Analgesic Cream · Vireo Systems, Inc.
Histamine dihydrochloride 0.25 mg/mL, cream (topical)
Active ingredient
Histamine DHCl 0.025% Purpose Topical Analgesic
Purpose
Topical Analgesic
Uses
For the temporary relief of minor aches and pains of muscles and joints, associated with arthritis, simple back aches, strains, bruises, and sprains. Provides penetrating pain relief.
Warnings
For External Use Only Do not apply to wounds or damaged skin. bandage tightly.
When using this product
Avoid contact with eyes.
Stop use and ask a doctor if
condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days.
Keep out of reach of children
If swallowed, get medical help orcontact a Poison Control Center right away.
If pregnant or breastfeeding
ask a health professional before use.
Directions
Adults and children 2 years of age and older: Apply to affected area not more than 3 to 4 times daily. Children under 2 years of age: consult a doctor.
Inactive ingredients
Alpha GEE®, Cetyl Alcohol, Colloidal Oatmeal, Dioctyl Sodium Sulfosuccinate, Glyceryl MonoStearate, Polyethylene Glycol, Polyethylene Glycol 400, Polyethylene Glycol 3350, Sodium Hydroxide.
— FDA label of AMINO ACTIVE Topical Analgesic Cream, Vireo Systems, Inc., effective November 11, 2023. See the official label on DailyMed →
ROPANA Pain Relief Cream · Fusion Pain Solutions LLC
Histamine dihydrochloride 0.4 mg/mL, cream (topical)
Active ingredient
Histamine DHCl 0.04% Purpose Topical Analgesic
Purpose
Topical Analgesic
Uses
For the temporary relief of minor aches and pains of muscles and joints, associated with simple backache, arthritis, strains, bruises, and sprains.
Warnings
For external use only
Do not use
on damaged or broken skin.
When using this product
Avoid contact with the eyes.
Stop use and ask a doctor if
Rash or irritation develops and lasts. Condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days.
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
If pregnant or breast-feeding
ask a health professional before use
Directions
Adults and children 2 years of age and older: Apply to affected area not more than 3 to 4 times daily. Chldren under 2 years of age: consult a doctor.
Inactive ingredients
Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Aloe Barbadensis Leaf (Aloe Vera Gel) Juice, Aqua (Deionized Water), Arnica Montana Flower Extract, Bis-Vinyl Dimethicone/Dimethicone Copolymer, Boswellia Serrata Extract, Butyrospermum Parkii (Shea) Butter, Cetyl Alcohol, Cinnamomum Cassia Oil, Curcuma Longa (Turmeric) Extract, Cyclopentasiloxane, Dodecane, Ethylhexylglycerin, Ethyl Vanillin, Glyceryl Stearate, Glycyrrhiza Glaba (Licorice) Extract, Helianthus Annuus (Sunflower) Oil, Isopropyl Myristate, Magnesium Sulfate, Methylsulfonylmethane (MSM), Phenoxyethanol, Polysorbate-20, Stearic Acid, Triethanolamine, Xanthan Gum.
— FDA label of ROPANA Pain Relief Cream, Fusion Pain Solutions LLC, effective November 6, 2023. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredient, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Histamine dihydrochloride 0.05% · cream (topical) · 4 products
Histamine dihydrochloride 0.03% · cream (topical) · 3 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Bakers Best Arthritis Pain Relief | Baker's Best Health Products, LLC | DailyMed |
| BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender | Baker'S Best Health Products, Inc. | DailyMed |
| Bakers Best Arthritis Pain Relief with Hemp Seed | Baker's Best Health Products, LLC | DailyMed |
Histamine dihydrochloride 0.025% · cream (topical) · 3 products
Histamine dihydrochloride 0.25 mg/mL · cream (topical) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| AMINO ACTIVE Topical Analgesic Cream | Vireo Systems, Inc. | DailyMed |
Histamine dihydrochloride 0.4 mg/mL · cream (topical) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| ROPANA Pain Relief Cream | Fusion Pain Solutions LLC | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Baker's Best Health Products, LLC2 products
- Sombra Cosmetics Inc.2 products
- Mediapower, Inc. DBA Dr Newton's and Naturals1 product
- Ideaz, LLC1 product
- Alpha Nutrition, LLC1 product
- Walgreens Company1 product
- Vireo Systems, Inc.1 product
- CVS Health1 product
- Baker'S Best Health Products, Inc.1 product
- Fusion Pain Solutions LLC1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.