Quick answers
- What is Diphenhydramine and zinc acetate used for?
- The Drug Facts label of Itch Relief (Bionpharma Inc.) lists these uses: dries the oozing and weeping of poison ivy, poison oak, and poison sumac; temporarily relieves pain and itching associated with: minor cuts; sunburn; scrapes; minor skin irritations; minor burns; insect bites; rashes due to poison ivy, poison oak and poison sumac.
- Do I need a prescription for Diphenhydramine and zinc acetate?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Diphenhydramine and zinc acetate been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Itch Relief · Bionpharma Inc.
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1%, cream (topical)
Active ingredient
Diphenhydramine Hydrochloride 2% Zinc Acetate 0.1%
Purpose
Topical Analgesic Skin Protectant
Uses
- dries the oozing and weeping of poison ivy, poison oak, and poison sumac
- temporarily relieves pain and itching associated with:
- minor cuts
- sunburn
- scrapes
- minor skin irritations
- minor burns
- insect bites
- rashes due to poison ivy, poison oak and poison sumac
Warnings
For external use only.
Do not use
- with any other product containing diphenhydramine, even one taken by mouth
- on large areas of the body
- on broken, blistered, or oozing skin Ask a doctor before use
- on measles
- on chicken pox
- on poison ivy
- on sunburn
When using this product
avoid contact with the eyes.
Stop use and ask a doctor if
- condition worsens or does not improve within 7 days
- symptoms persist for more than 7 days or clear up and occur again within a few days
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
- children under 2 years of age: ask a doctor
- adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily
- do not use more than directed
Inactive ingredients
carbomer homopolymer type c, cetyl alcohol, glycerin, glyceryl monostearate, light mineral oil, methylparaben, polysorbate 60, propylparaben, purified water, stearic acid
— FDA label of Itch Relief, Bionpharma Inc., effective July 16, 2024. See the official label on DailyMed →
Rite Aid Itch Relief · Rite Aid
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1%, spray (topical)
Active ingredient
Diphenhydramine HCl 2%, Zinc Acetate 0.1%
Purpose
Topical Analgesic, Skin Protectant
Uses
For the temporary relief of pain and itching associated with insect bites, minor burns, sunburn, minor cuts, scrapes, minor skin irritations, and rashes due to poison ivy, oak, and sumac. Dries the oozing and weeping of poison ivy, oak, and sumac.
Warnings
For external use only. Flammable-- Keep away from fire or flame.
Do not use
on chicken pox, on large areas of the body, with any other products containing diphenhydramine, even one taken by mouth.
When using this product
avoid contact with eyes. In case of contact with eyes, flush thoroughly with water. Contents under pressure. Do not puncture or incinerate. Do not store at temperature above 120F. .
Stop use and ask a doctor if
condition worsens, if symptoms persist for more than 7 days or clear up and occur again within a few days. If swallowed, get medical help or contact a Poison Control Center right away.
Directions
Shake well before use. Adults and children 12 years of age and older, apply to the affected area not more than 3 to 4 times daily. Children under 12 years of age: ask a doctor. To apply to face, spray into palm of hand and gently apply.
Inactive ingredients
Alcohol, Glycerin, PVP, Purified Water, Tromethamine.
— FDA label of Rite Aid Itch Relief, Rite Aid, effective April 23, 2026. See the official label on DailyMed →
Walgreens Original Strength Anti Itch · Walgreen Company
Diphenhydramine hydrochloride 1% · Zinc acetate 0.1%, cream (topical)
Active ingredient
Purposes Diphenhydramine hydrochloride 1% Topical analgesic Zinc acetate 0.1% Skin protectant
Purpose
Active ingredients Purposes Diphenhydramine hydrochloride 1% Topical analgesic Zinc acetate 0.1% Skin protectant
Uses
Temporarily relieves pain and itching associated with: insect bites minor burns sunburn scrapes minor skin irritations minor cuts Dries the oozing and weeping of poison ivy, poison oak and poison sumac
Warnings
For external use only. Avoid contact with eyes.
Do not use
more than directed on large areas of the body with any product containing diphenhydramine even one taken by mouth Ask a doctor before use on chicken pox on measles
Stop use and ask a doctor if
condition worsens or does not improve within 7 days symptoms persist for more than 7 days or clear up and occur again within a few days
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away: 800-222-1222.
Directions
do not use more than directed Adults and children 2 years of age and older: apply to affected area up to 4 times daily Children under 2 years of age: ask a doctor
Inactive ingredients
cetearyl alcohol (and) polysorbate 60, DMDM hydantoin, glyceryl stearate, isopropyl myristate, methylparaben, mineral oil, propylparaben, purified water
Questions?
1-866-323-0107
— FDA label of Walgreens Original Strength Anti Itch, Walgreen Company, effective January 28, 2026. See the official label on DailyMed →
Benadryl Extra Strength Itch Cooling · Kenvue Brands LLC
Diphenhydramine hydrochloride 20 mg/mL · Zinc acetate 1 mg/mL, spray (topical)
Active ingredient
Purpose Diphenhydramine HCl 2% Topical analgesic Zinc acetate 0.1% Skin protectant
Purpose
Active ingredients Purpose Diphenhydramine HCl 2% Topical analgesic Zinc acetate 0.1% Skin protectant
Uses
temporarily relieves pain and itching associated with: insect bites minor burns sunburn minor skin irritations minor cuts scrapes rashes due to poison ivy, poison oak, and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
Warnings
For external use only. Flammable. Keep away from fire or flame.
Do not use
on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles
When using this product
avoid contact with eyes
Stop use and ask a doctor if
condition worsens or does not improve within 7 days symptoms persist for more than 7 days or clear up and occur again within a few days
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
do not use more than directed adults and children 2 years of age and older: spray on affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor
Inactive ingredients
alcohol, glycerin, PVP, purified water, tromethamine
Questions?
call 1-800-524-2624 (English/Spanish)
— FDA label of Benadryl Extra Strength Itch Cooling, Kenvue Brands LLC, effective July 18, 2025. See the official label on DailyMed →
Diphenhydramine HCl and Zinc Acetate · Walgreen Company
Diphenhydramine hydrochloride 1.52 g/76 g · Zinc acetate 0.076 g/76 g, spray (topical)
Active ingredient
Diphenhydramine HCl 2.0% Zinc Acetate 0.1%
Purpose
External Analgesic Skin protectant
Uses
for temporary relief of pain and itching associated with: minor burns sunburns minor cuts scrapes insect bites minor skin irritations rashes due to poison ivy, poison oak and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
Warnings
For external use only.
- Flammable: Keep away from fire or flame. Do not puncture or incinerate. Contents under pressure. Do not store at temperature above 120ºF. Intentional misuse by deliberately concentrating and inhaling contents cans be harmful or fatal.
Do not use
on large areas of the body with any other products containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles Stop use and ask doctor if condition worsens symptoms last more than 7 days or clear up and occur again within a few days
When using this product
avoid contact with eyes use only as directed
Keep out of reach of children
If swallowed, get medical help or contact a Poison Control Center right away.
Directions
adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor
Other information
store between 20° to 25°C (68° to 77°F)
Inactive ingredients
aloe barbadensis leaf juice, glycerin, purified water, SD alcohol 40-B, tromethamine
Questions?
call 1-866-964-0939
— FDA label of Diphenhydramine HCl and Zinc Acetate, Walgreen Company, effective November 6, 2025. See the official label on DailyMed →
Itch Relief · Hy-Vee, Inc
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1%, aerosol, spray (topical)
Active ingredient
Diphenhydramine HCI 2.0% Zinc acetate 0.1%
Purpose
External analgesic Skin protectant
Uses
for the temporary relief of pain and itching associated with: minor burns sunburn minor cuts scrapes insect bites minor skin irritations rashes due to poison ivy, poison oak and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac
Warnings
For external use only.
- Flammable: Keep away from fire or flame. Do not puncture or incinerate. Contents under pressure. Do not store at temperatures above 120ºF. Intentional misuse by deliberately concentrating and inhaling contents can be harmful or fatal.
Do not use
on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox on measles
When using this product
avoid contact with eyes Stop use and ask doctor if condition worsens symptoms last more than 7 days or clear up and occur again within a few days Keep out of the reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Directions
do not use more often than directed adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor
Other information
store between 20º to 25ºC (68º to 77ºF)
Inactive ingredients
aloe barbadensis leaf juice, glycerin, purified water, SD alcohol 40-B, tromethamine
Questions?
Call 1-800-289-8343
— FDA label of Itch Relief, Hy-Vee, Inc, effective January 12, 2026. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1% · cream (topical) · 38 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Anti Itch | Kroger Company | DailyMed |
| Anti Itch | Meijer Distribution Inc | DailyMed |
| Anti-itch | Target Corporation | DailyMed |
| Anti-Itch Cream | Chain Drug Marketing Association Inc. | DailyMed |
| Anti-Itch Cream | Kroger | DailyMed |
| Anti-Itch Cream | Trifecta Pharmaceuticals USA, LLC. | DailyMed |
| Banophen | Major Pharmaceuticals | DailyMed |
| Benadryl Extra Strength Itch Stopping | Kenvue Brands LLC | DailyMed |
| CAREALL Anti-Itch | New World Imports, Inc | DailyMed |
| Caring Mill Anti-Itch Cream | Veridian Healthcare | DailyMed |
| CVS Extra Strength Itch Stopping | Cvs | DailyMed |
| Diphenhydramine HCL and Zinc Acetate | Padagis Israel Pharmaceuticals Ltd | DailyMed |
| Diphenhydramine Hydrochloride and Zinc Acetate | Strategic Sourcing Services LLC | DailyMed |
| Diphenhydramine Hydrochloride and Zinc Acetate | Sun Pharmaceutical Industries, Inc. | DailyMed |
| Discount Drug Mart Extra Strength Itch Stopping | Discount Drug Mart | DailyMed |
| Dr. Sheffield Anti Itch Cream | Sheffield Pharmaceuticals LLC | DailyMed |
| Equate Anti Itch | Wal-Mart Stores Inc | — |
| Extra Strength Itch Stopping | Universal Distribution Centre LLC | DailyMed |
| Family Wellness | Front Pharmaceutical PLC | DailyMed |
| Family Wellness | Zhejiang Jingwei Pharmaceutical Co., Ltd. | DailyMed |
| Foster and Thrive Anti Itch Cream | Strategic Sourcing Services LLC | DailyMed |
| Good Sense Itch Relief | L. Perrigo Company | DailyMed |
| Itch and Pain Relief | Alaina Healthcare Private Limited | — |
| Itch Relief | Bionpharma Inc. | DailyMed |
| Itch Relief | CVS Pharmacy | DailyMed |
Showing 25 of 38 brands.
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1% · spray (topical) · 10 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Best Choice Itch Relief | Valu Merchandisers | DailyMed |
| CVS Itch Relief | Cvs | DailyMed |
| Extra Strength Itch Relief | Chain Drug Marketing Association Inc | DailyMed |
| Extra Strength Itch Relief | Meijer Distribution Inc | DailyMed |
| Good neighbor Pharmacy Itch Relief | Amerisourcebergen Drug Corporation | DailyMed |
| GoodSense Anti-Itch | Geiss, Destin & Dunn, Inc | DailyMed |
| Quality Choice Itch Relief | Chain Drug Marketing Association | DailyMed |
| Rite Aid Itch Relief | Rite Aid | DailyMed |
| Warrior First Aid Anti Itch | Derma Care Research Labs, LLC | DailyMed |
| Westlake Itch Relief | Westlake HB Pharma LLC | DailyMed |
Diphenhydramine hydrochloride 1% · Zinc acetate 0.1% · cream (topical) · 6 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Anti-Itch | Ol Pharma Tech, LLC | DailyMed |
| Benadryl Original Strength Itch Stopping | Kenvue Brands LLC | DailyMed |
| CVS Regular Strength Itch Stopping | Cvs | DailyMed |
| Discount Drug Mart Regular Strength Itch Stopping | Discount Drug Mart | DailyMed |
| Walgreens Original Strength Anti Itch | Walgreen Company | DailyMed |
| WinCo Original Strength Anti-Itch | WinCo Foods, LLC | DailyMed |
Diphenhydramine hydrochloride 20 mg/mL · Zinc acetate 1 mg/mL · spray (topical) · 6 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Benadryl Extra Strength Itch Cooling | Kenvue Brands LLC | DailyMed |
| Extra Strength Wal-Dryl Itch Relief | Walgreen Co | DailyMed |
| Itch Relief | Cardinal Health, 110 dba Leader | DailyMed |
| Itch Relief | Meijer, Inc. | DailyMed |
| Itch Relief | Old East Main Co. | DailyMed |
| Itch Relief | The Kroger Co. | — |
Diphenhydramine hydrochloride 1.52 g/76 g · Zinc acetate 0.076 g/76 g · spray (topical) · 3 products
Diphenhydramine hydrochloride 2% · Zinc acetate 0.1% · aerosol, spray (topical) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Itch Relief | Hy-Vee, Inc | DailyMed |
Diphenhydramine hydrochloride 1.5 g/76 g · Zinc acetate 0.075 g/76 g · aerosol, spray (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Diphenhydramine HCl and Zinc Acetate | Topco Associates LLC | DailyMed |
Diphenhydramine hydrochloride 20% · Zinc acetate 0.1% · cream (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Medi First Extra Strength Itch Relief | Unifirst First Aid Corporation | DailyMed |
Diphenhydramine hydrochloride 1.5 g/76 g · Zinc acetate 0.076 g/76 g · aerosol, spray (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Itch Relief | CVS Pharmacy | DailyMed |
Diphenhydramine hydrochloride 1.52 g/88 mL · Zinc acetate 0.076 g/88 mL · spray (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Diphenhydramine HCl and Zinc Acetate | Valu Merchandisers, Co | DailyMed |
Diphenhydramine hydrochloride 1.5 g/88 mL · Zinc acetate 0.075 g/88 mL · aerosol, spray (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Diphenhydramine HCl and Zinc Acetate | Wal-Mart Stores, Inc. | DailyMed |
Diphenhydramine hydrochloride 20 mg/mL · Zinc acetate 1 mg/mL · solution (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Benadryl Extra Strength Itch Relief | Kenvue Brands LLC | DailyMed |
Diphenhydramine hydrochloride 20 mg/mL · Zinc acetate 1 mg/mL · liquid (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Industrial Itch and Pain Relief | R & R Lotion, Inc | DailyMed |
Diphenhydramine HCL 2% · Zinc acetate 0.1% · cream (topical) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| GNP Extra Strength Anti-Itch Cream | Amerisource Bergen | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| diphenhydramine HCL 2% · zinc acetate 0.1% cream | Generic | $0.0587 per gram |
| diphenhydramine hydrochloride 2% · zinc acetate 0.1% cream | Generic | $0.0587 per gram |
| diphenhydramine hydrochloride 2% · zinc acetate 0.1% spray | Generic | $0.0474 per mL |
| diphenhydramine hydrochloride 20 mg/mL · zinc acetate 1 mg/mL spray | Generic | $0.0474 per mL |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Kenvue Brands LLC4 products
- Meijer Distribution Inc3 products
- Cvs3 products
- Discount Drug Mart2 products
- Trifecta Pharmaceuticals USA, LLC.2 products
- Chain Drug Marketing Association Inc2 products
- Topco Associates LLC2 products
- CVS Pharmacy2 products
- Walgreen Company2 products
- Strategic Sourcing Services LLC2 products
- Veridian Healthcare2 products
- Wal-Mart Stores, Inc.2 products
- Rite Aid2 products
- Shopko Stores Operating Co., LLC1 product
- Hy-Vee, Inc1 product
- Bionpharma Inc.1 product
- Heb1 product
- HyVee Inc1 product
- Amerisourcebergen Drug Corporation1 product
- Unifirst First Aid Corporation1 product
- Walgreens Company1 product
- Cardinal Health, 110 dba Leader1 product
- Cardinal Health 110, LLC. dba Leader1 product
- Old East Main Co.1 product
- Valu Merchandisers, Co1 product
- Pharmacy Value Alliance LLC1 product
- Walgreen Co1 product
- Ol Pharma Tech, LLC1 product
- Sheffield Pharmaceuticals LLC1 product
- Meijer, Inc.1 product
Showing the 30 companies with the most products, of 55.
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Next steps
- Find a pharmacy near youA pharmacist can answer questions about this label
- BenadrylBrand page: products, maker and price
- Latest FDA drug recallsPrescription and over-the-counter, newest first
- All over-the-counter medicinesSearch by ingredient, brand or Spanish name
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.