Quick answers
- What is Diphenhydramine and phenylephrine used for?
- The Drug Facts label of Benadryl Allergy Plus Congestion (Kenvue Brands LLC) lists these uses: temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat nasal congestion temporarily relieves these symptoms due to the common cold: runny nose sneezing nasal congestion temporarily relieves sinus congestion and pressure.
- Do I need a prescription for Diphenhydramine and phenylephrine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Diphenhydramine and phenylephrine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Benadryl Allergy Plus Congestion · Kenvue Brands LLC
Diphenhydramine hydrochloride 25 mg · Phenylephrine hydrochloride 10 mg, tablet, film coated (oral)
Active ingredient (in each tablet)
Purposes Diphenhydramine HCl 25 mg Antihistamine Phenylephrine HCl 10 mg Nasal decongestant
Purpose
Active ingredients (in each tablet) Purposes Diphenhydramine HCl 25 mg Antihistamine Phenylephrine HCl 10 mg Nasal decongestant
Uses
temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat nasal congestion temporarily relieves these symptoms due to the common cold: runny nose sneezing nasal congestion temporarily relieves sinus congestion and pressure
Warnings
Do not use
to make a child sleepy with any other product containing diphenhydramine, even one used on skin if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have heart disease high blood pressure thyroid disease diabetes trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis glaucoma
Ask a doctor or pharmacist before use if
you are taking sedatives or tranquilizers
When using this product
do not exceed recommended dose marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children
Stop use and ask a doctor if
nervousness, dizziness, or sleeplessness occur symptoms do not improve within 7 days or occur with a fever
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
Directions
| adults and children 12 years and over |
|
| children under 12 years | ask a doctor |
Inactive ingredients
carnauba wax, FD&C blue no. 1 aluminum lake, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polyvinyl alcohol, powdered cellulose, pregelatinized starch, sodium starch glycolate, talc, titanium dioxide
Questions?
call 1-888-217-2117 (toll-free) or 215-273-8755 (collect)
— FDA label of Benadryl Allergy Plus Congestion, Kenvue Brands LLC, effective November 8, 2024. See the official label on DailyMed →
Childrens Cold and Cough Nighttime · Safeway, Inc.
Diphenhydramine hydrochloride 6.25 mg/5 mL · Phenylephrine hydrochloride 2.5 mg/5 mL, liquid (oral)
Active ingredient (in each 5 mL)
Diphenhydramine HCl 6.25 mg Phenylephrine HCl 2.5 mg
Purpose
Antihistamine/Cough suppressant Nasal decongestant
Uses
temporarily relieves sneezing runny nose itchy nose or throat itchy, watery eyes due to hay fever nasal and sinus congestion cough due to minor throat and bronchial irritations as may occur with a cold
Warnings
Do not use
in a child under 4 years of age in a child who is taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child's prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product. with any other product containing diphenhydramine, even one used on skin for the purpose of making your child sleepy
Ask a doctor before use if
the child has heart disease high blood pressure thyroid disease diabetes glaucoma cough that occurs with too much phlegm (mucus) chronic cough that lasts, or as occurs with asthma a breathing problem such as chronic bronchitis
Ask a doctor or pharmacist before use if
the child is taking sedative or tranquilizers.
When using this product
do not exceed recommended dosage marked drowsiness may occur excitability may occur, especially in children sedatives and tranquilizers may increase drowsiness
Stop use and ask a doctor if
nervousness, dizziness or sleeplessness occurs symptoms do not improve within 7 days or occur with a fever cough persists for more than 7 days, comes back or occurs with fever, rash or persistent headache. These could be signs of a serious condition.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Directions
Do not give more than 6 doses in 24 hours unless directed by a doctor. measure only with dosing cup provided Do not use any other dosing device keep dosing cup with product mL=mililiter shake well before using
| Age | Dose |
| children 6 to under 12 years | 10 mL every 4 hours |
| children 4 to under 6 years | do not use unless directed by a doctor |
| children under 4 years of age | do not use |
Inactive ingredients
acesulfame potassium, anhydrous citric acid, EDTA disodium, FD&C blue #1, FD&C red #40, flavor, maltitol, propylene glycol, purified water, sodium benzoate, trisodium citrate dihydrate
Questions?
Call 1-888-723-3929 Monday-Friday 7AM-6PM PST
— FDA label of Childrens Cold and Cough Nighttime, Safeway, Inc., effective May 15, 2024. See the official label on DailyMed →
Vicks childrens Cough Congestion Night · The Procter & Gamble Manufacturing Company
Diphenhydramine hydrochloride 12.5 mg/15 mL · Phenylephrine hydrochloride 5 mg/15 mL, liquid (oral)
Active ingredient (in each 15 mL)
Diphenhydramine HCl 12.5 mg Phenylephrine HCl 5 mg Purpose Antihistamine/Cough suppressant Nasal decongestant
Purpose
Antihistamine/Cough suppressant Nasal decongestant
Uses
temporarily relieves common cold symptoms: nasal congestion runny nose & sneezing cough due to minor throat and bronchial irritation
Warnings
Do not use
with any other product containing diphenhydramine, even one used on skin to make a child sleepy if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have heart disease high blood pressure thyroid disease diabetes glaucoma trouble urinating due to enlarged prostate gland cough that occurs with too much phlegm (mucus) a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, or emphysema a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are taking sedatives or tranquilizers
When using this product
do not use more than directed. excitability may occur, especially in children marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks be careful when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
you get nervous, dizzy or sleepless symptoms do not improve within 7 days or occur with a fever cough persists for more than 7 days, comes back or occurs with a fever, rash or persistent headache These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
Directions
take only as directed only use the dose cup provided do not exceed 4 doses per 24 hrs
| adults & children 12 yrs & over | 30 mL every 4 hrs |
| children 6 to under 12 yrs | 15 mL every 4 hrs |
| children 4 to under 6 yrs | do not use unless directed by a doctor |
| children under 4 yrs | do not use |
Inactive ingredients
anhydrous citric acid, flavor, glycerin, polysorbate 20, propylene glycol, purified water, saccharin sodium, sodium benzoate, sodium chloride, sodium citrate, sorbitol solution, sucralose
Questions?
1-800-362-1683
— FDA label of Vicks childrens Cough Congestion Night, The Procter & Gamble Manufacturing Company, effective March 26, 2026. See the official label on DailyMed →
Childrens Benadryl Allergy Plus Congestion · Kenvue Brands LLC
Diphenhydramine hydrochloride 12.5 mg/5 mL · Phenylephrine hydrochloride 5 mg/5 mL, solution (oral)
Active ingredient (in each 5 mL)
Purposes Diphenhydramine HCl 12.5 mg Antihistamine Phenylephrine HCl 5 mg Nasal decongestant
Purpose
Active ingredients (in each 5 mL) Purposes Diphenhydramine HCl 12.5 mg Antihistamine Phenylephrine HCl 5 mg Nasal decongestant
Uses
temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose sneezing itchy, watery eyes itching of the nose or throat nasal congestion stuffy nose temporarily relieves these symptoms due to the common cold: runny nose sneezing nasal congestion stuffy nose temporarily relieves sinus congestion and pressure
Warnings
Do not use
to make a child sleepy with any other product containing diphenhydramine, even one used on skin if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have heart disease high blood pressure thyroid disease diabetes trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis glaucoma
Ask a doctor or pharmacist before use if
you are taking sedatives or tranquilizers
When using this product
do not exceed recommended dose marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children
Stop use and ask a doctor if
nervousness, dizziness, or sleeplessness occur symptoms do not improve within 7 days or occur with a fever
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)
Directions
find right dose on chart below mL = milliliter take every 4 hours do not take more than 6 doses in 24 hours
| Age (yr) | Dose (mL) |
|---|---|
| children under 4 years | do not use |
| children 4 to 5 years | do not use unless directed by a doctor |
| children 6 to 11 years | 5 mL |
| adults and children 12 years and over | 10 mL |
Attention: use only enclosed dosing cup specifically designed for use with this product. Do not use any other dosing device.
Inactive ingredients
anhydrous citric acid, carboxymethylcellulose sodium, edetate disodium, FD&C blue no. 1, FD&C red no. 40, flavors, glycerin, purified water, sodium benzoate, sodium citrate, sorbitol solution, sucralose
Questions?
call 1-877-717-2824 (toll-free) or 215-273-8755 (collect)
— FDA label of Childrens Benadryl Allergy Plus Congestion, Kenvue Brands LLC, effective November 8, 2024. See the official label on DailyMed →
Dimetapp Nighttime Cold and Congestion · Foundation Consumer Brands
Diphenhydramine hydrochloride 6.25 mg/5 mL · Phenylephrine hydrochloride 2.5 mg/5 mL, solution (oral)
Active ingredient (in each 10 mL)
Purposes Diphenhydramine HCl, 12.5 mg Antihistamine/cough suppressant Phenylephrine HCl, 5 mg Nasal decongestant
Purpose
Active ingredients (in each 10 mL) Purposes Diphenhydramine HCl, 12.5 mg Antihistamine/cough suppressant Phenylephrine HCl, 5 mg Nasal decongestant
Uses
temporarily relieves: nasal congestion runny nose cough sneezing itching of the nose or throat itchy, watery eyes due to hay fever temporarily restores freer breathing through the nose
Warnings
Do not use
to sedate a child or to make a child sleepy If you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. with any other product containing diphenhydramine, even one used on skin
Ask a doctor before use if
you have heart disease high blood pressure thyroid disease diabetes trouble urinating due to an enlarged prostate gland glaucoma cough that occurs with too much phlegm (mucus) a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
Ask a doctor or pharmacist before use if
you are taking any other oral nasal decongestant or stimulant taking sedatives or tranquilizers
When using this product
do not use more than directed may cause marked drowsiness avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children
Stop use and ask a doctor if
nervousness, dizziness or sleeplessness occurs symptoms do not get better within 7 days or are accompanied by fever cough lasts more than 7 days, comes back, or is accompanied by fever, rash or persistent headache. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
do not take more than 6 doses in any 24-hour period measure only with dosage cup provided keep dosage cup with product mL = milliliter
| age | dose |
|---|---|
| adults and children 12 years and over | 20 mL every 4 hours |
| children 6 to under 12 years | 10 mL every 4 hours |
| children under 6 years | do not use |
Inactive ingredients
anhydrous citric acid, artificial flavor, FD&C blue no.1, FD&C red no. 40, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium citrate, sorbitol solution, sucralose
Questions?
Call 1-888-594-0828 weekdays 9 AM to 5 PM EST
— FDA label of Dimetapp Nighttime Cold and Congestion, Foundation Consumer Brands, effective February 23, 2026. See the official label on DailyMed →
Cold and Congestion Childrens Nighttime · Walgreens
Diphenhydramine hydrochloride 12.5 mg/10 mL · Phenylephrine hydrochloride 5 mg/10 mL, liquid (oral)
Active ingredient (in each 10 mL)
Diphenhydramine HCI 12.5 mg Phenylephrine HCI 5 mg
Purpose
Antihistamine/Cough suppressant Nasal decongestant
Uses
temporarily relieves these symptoms occuring with a cold, hay fever, or other upper respiratory allergies nasal congestion cough runny nose sneezing itchy, watery eyes itching of the nose or throat
Warnings
Do not use
to sedate a child or to make a child sleepy if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. with any other product containing diphenhydramine, even one used on skin.
Ask a doctor before use if
you have heart disease high blood pressure thyroid disease diabetes glaucoma trouble urinating due to an enlarged prostate gland cough that occurs with too much phlem (mucus) a breathing problem or chronic cough that last or as occurs with smoking, asthma, chronic bronchitis, or emphysena.
Ask a doctor or pharmacist before use if
you are taking any other oral nasal decongestant or stimulant taking sedatives or tranquilizers
When using this product
do not use more than directed marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children
Stop use and ask a doctor if
you get nervous, dizzy or sleepless symptoms do not get better within 7 days or occur with a fever cough lasts more than 7 days, comes back, or is accompanied by a fever, rash, or persistent headache. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Directions
do not take more than 6 doses in any 24-hour period do not exceed recommended dosage measure only with dosing cup provided. Do not use any other dosing device. keep dosing cup with product mL = milliliter
| age | dose |
| adults and children 12 years and over | 20 mL every 4 hours |
| children 6 to 11 years | 10 mL every 4 hours |
| children under 6 years | do not use |
Inactive ingredients
acesulfame potassium anhydrous citric acid, EDTA disodium, FD&C blue #1, FD&C red # 40, flavor, maltitol, propylene glycol, purified water, sodium benzoate, trisodium citrate dihydrate
Questions?
Call 1-877-753-3935 Monday-Friday 9AM-5PM EST
— FDA label of Cold and Congestion Childrens Nighttime, Walgreens, effective October 9, 2023. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Diphenhydramine hydrochloride 25 mg · Phenylephrine hydrochloride 10 mg · tablet, film coated (oral) · 4 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Allergy Plus Congestion Relief | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| Allergy Plus Sinus Relief | Rite Aid Corporation | DailyMed |
| Allergy Relief Plus Congestion | Walgreen Company | DailyMed |
| Benadryl Allergy Plus Congestion | Kenvue Brands LLC | DailyMed |
Diphenhydramine hydrochloride 6.25 mg/5 mL · Phenylephrine hydrochloride 2.5 mg/5 mL · liquid (oral) · 2 products
Diphenhydramine hydrochloride 12.5 mg/15 mL · Phenylephrine hydrochloride 5 mg/15 mL · liquid (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Vicks childrens Cough Congestion Night | The Procter & Gamble Manufacturing Company | DailyMed |
Diphenhydramine hydrochloride 12.5 mg/5 mL · Phenylephrine hydrochloride 5 mg/5 mL · solution (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Childrens Benadryl Allergy Plus Congestion | Kenvue Brands LLC | DailyMed |
Diphenhydramine hydrochloride 6.25 mg/5 mL · Phenylephrine hydrochloride 2.5 mg/5 mL · solution (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Dimetapp Nighttime Cold and Congestion | Foundation Consumer Brands | DailyMed |
Diphenhydramine hydrochloride 12.5 mg/10 mL · Phenylephrine hydrochloride 5 mg/10 mL · liquid (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Cold and Congestion Childrens Nighttime | Walgreens | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Kenvue Brands LLC2 products
- The Procter & Gamble Manufacturing Company1 product
- Walgreen Company1 product
- Best Choice (Valu Merchandisers Company)1 product
- Foundation Consumer Brands1 product
- Safeway, Inc.1 product
- Walgreens1 product
- Rite Aid Corporation1 product
- Cvs Woonsocket Prescription Center, Incorporated1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.