Quick answers
- What is Acetaminophen, pamabrom and pyrilamine used for?
- The Drug Facts label of Thompson Cramp Relief (Thompson Safety) lists these uses: for the temporary relief of these symptoms associated with menstrual periods; headache; bloating; cramps; backache; muscular aches; irritability; water-weight gain.
- Do I need a prescription for Acetaminophen, pamabrom and pyrilamine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen, pamabrom and pyrilamine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Thompson Cramp Relief · Thompson Safety
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Acetaminophen 500 mg Pamabrom 25 mg Pyrilamine maleate 15 mg
Purpose
Pain reliever Diuretic Antihistamine
Uses
for the temporary relief of these symptoms associated with menstrual periods:
- headache
- bloating
- cramps
- backache
- muscular aches
- irritability
- water-weight gain
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- difficulty in urination due to enlargement of the prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- liver disease
- glaucoma
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- drowsiness may occur
- avoid alcoholic beverages
- excitability may occur, especially in children
- alcohol, sedatives and tranquilizers may increase drowsiness
- use caution when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- new symptoms occur
- redness or swelling is present These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of accidental overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed Adults and children: (12 years and over)
- take 2 caplets with water every 6 hours as needed
- do not exceed 6 caplets in a 24 hour period or as directed by a doctor Children under 12 years: ask a doctor
Other information
- store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)
- tamper-evident sealed packets
- do not use any opened or torn packets
Inactive ingredients
corn starch, croscarmellose sodium, crospovidone, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, shellac wax, silicon dioxide, stearic acid, talc, titanium dioxide
Questions?
877.506.4291
— FDA label of Thompson Cramp Relief, Thompson Safety, effective January 8, 2026. See the official label on DailyMed →
Pamprin Multi-Symptom Maximum Strength · Focus Consumer Healthcare, LLC
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg, tablet (oral)
Active ingredient
Drug Facts Active ingredients (in each caplet) Acetaminophen 500 mg Pamabrom 25 mg Pyrilamine maleate 15 mg
Purpose
Pain reliever Diuretic Antihistamine
Uses
for the temporary relief of these symptoms associated with menstrual periods:
- cramps
- headache
- bloating
- backache
- water-weight gain
- muscular aches
- irritability
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 8 caplets in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product Allergy alert : Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use if
you have
- liver disease
- glaucoma
- a breathing problem such as emphysema or chronic bronchitis
- difficulty in urination due to enlargement of the prostate gland
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- you may get drowsy, avoid alcoholic beverages
- alcohol, sedatives and tranquilizers may increase drowsiness
- use caution when driving or operating machinery
- excitability may occur, especially in children
Stop use and ask a doctor if
- pain gets worse or lasts for more than 10 days
- fever gets worse or lasts for more than 3 days
- new symptoms occur
- redness or swelling is present
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
adults and children 12 years and over:
- take 2 caplets with water every 6 hours as needed
- do not exceed 8 caplets in a 24 hour period or as directed by a doctor
- do not use more than directed (see warnings) children under 12 years: ask a doctor
Inactive ingredients
blue 2, candelilla wax, corn starch, ethylparaben, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, pregelatinized starch, propylparaben, red 40, sodium starch glycolate, stearic acid, talc, titanium dioxide
Questions?
www.pamprin.com
— FDA label of Pamprin Multi-Symptom Maximum Strength, Focus Consumer Healthcare, LLC, effective April 20, 2026. See the official label on DailyMed →
Medi First Plus PMS Relief · Unifirst First Aid Corporation
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg, tablet, coated (oral)
Active ingredient (in each caplet)
Acetaminophen 500 mg Pamabrom 25 mg Pyrilamine maleate 15 mg
Purpose
Pain reliever Diuretic Antihistamine
Uses
for the temporary relief of these symptoms associated with menstrual periods:
- headache
- bloating
- cramps
- backache
- muscular aches
- irritability
- water-weight gain
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- difficulty in urination due to enlargement of the prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- liver disease
- glaucoma
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- drowsiness may occur
- avoid alcoholic beverages
- excitability may occur, especially in children
- alcohol, sedatives and tranquilizers may increase drowsiness
- use caution when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- new symptoms occur
- redness or swelling is present These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of accidental overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed Adults and children: (12 years and over)
- take 2 caplets with water every 6 hours as needed
- do not exceed 6 caplets in a 24 hour period or as directed by a doctor Children under 12 years: ask a doctor
Other information
- store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)
- tamper-evident sealed packets
- do not use any opened or torn packets
Inactive ingredients
corn starch, croscarmellose sodium, crospovidone, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, shellac wax, silicon dioxide, stearic acid, talc, titanium dioxide
Questions?
1-800-634-7680
— FDA label of Medi First Plus PMS Relief, Unifirst First Aid Corporation, effective September 9, 2025. See the official label on DailyMed →
Cramp Tabs · JHK DBA American Safety & First Aid
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg, capsule, coated (oral)
Active ingredient (In Each Caplet)
Purpose Acetaminophen 500mg pain reliever/fever reducer Pamabrom 25mg diuretic Pyrilamine maleate 15 mg Antihistamine
Purpose
Active ingredient (In Each Caplet) Purpose Acetaminophen 500mg pain reliever/fever reducer Pamabrom 25mg diuretic Pyrilamine maleate 15 mg Antihistamine
Uses
for the temporary relief of these symptoms associated with menstrual periods: headache bloating cramps backache muscular aches muscular aches irritability water-weight gain
Warnings
Liver warning This product contains acetaminophen. Severe liver damage may occur if you take: more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash if a skin reaction occurs, stop use and seek medical help right away.
Do not use
with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have difficulty in urination due to enlargement of the prostate gland a breathing problem such as emphysema or chronic bronchitis liver disease glaucoma
Ask a doctor or pharmacist before use if
you are taking sedatives or tranquilizers taking the blood thinning drug warfarin
When using this product
drowsiness may occur avoid alcoholic beverages excitability may occur, especially in children alcohol, sedatives and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days new symptoms occur redness or swelling is present These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of accidental overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
do not take more than directed adults and children 12 years and over: take 2 caplets with water every 6 hours as needed do not exceed 6 caplets in a 24 hour period or as directed by a doctor children under 12 years: ask a doctor
Inactive ingredients
corn starch, croscarmellose sodium, crospovidone, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, shellac wax, silicon dioxide, stearic acid, talc, titanium dioxide
Questions?
1-866-651-3660 Monday-Friday 8:00am-5:00pm EST
— FDA label of Cramp Tabs, JHK DBA American Safety & First Aid, effective October 4, 2024. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg · tablet, film coated (oral) · 12 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Green Guard Cramp Relief | Unifirst First Aid Corporation | DailyMed |
| Menstrual Pain Relief | Chain Drug Marketing Association, Inc. | — |
| Menstrual Pain Relief Maximum Strength | Rite Aid Corporation | DailyMed |
| Menstrual Pain Relief Maximum Strength / Multi Symptom | Dolgencorp, LLC | DailyMed |
| Menstrual Relief Maximum Strength | Army and Air Force Exchange Service | DailyMed |
| Menstrual Relief Maximum Strength | Family Dollar Services Inc | DailyMed |
| Menstrual Relief Maximum Strength | L.N.K. International, Inc. | — |
| Menstrual Relief Maximum Strength | Topco Associates, LLC | — |
| Menstrual Relief Maximum Strength Multi Symptom | Cardinal Health 110, LLC. DBA Leader | — |
| Multi-Symptom PMS Relief | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| PMS Relief Maximum Strength | CVS Pharmacy | DailyMed |
| Thompson Cramp Relief | Thompson Safety | DailyMed |
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg · tablet (oral) · 3 products
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg · tablet, coated (oral) · 2 products
Acetaminophen 500 mg · Pamabrom 25 mg · Pyrilamine maleate 15 mg · capsule, coated (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Cramp Tabs | JHK DBA American Safety & First Aid | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| acetaminophen 500 mg · pamabrom 25 mg · pyrilamine maleate 15 mg tablet, film coated | Generic | $0.0918 per tablet |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Unifirst First Aid Corporation3 products
- Focus Consumer Healthcare, LLC2 products
- Cvs Woonsocket Prescription Center, Incorporated1 product
- Topco Associates, LLC1 product
- CVS Pharmacy1 product
- Bayer HealthCare LLC.1 product
- Cardinal Health 110, LLC. DBA Leader1 product
- L.N.K. International, Inc.1 product
- Army and Air Force Exchange Service1 product
- Thompson Safety1 product
- Rite Aid Corporation1 product
- JHK DBA American Safety & First Aid1 product
- Family Dollar Services Inc1 product
- Chain Drug Marketing Association, Inc.1 product
- Dolgencorp, LLC1 product
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.