Quick answers
- What is Acetaminophen, dextromethorphan, doxylamine and phenylephrine used for?
- The Drug Facts label of CVS NightTime Cold (Cvs Pharmacy) lists these uses: temporarily relieves common cold/flu symptoms; nasal congestion; sinus congestion & pressure; cough due to minor throat & bronchial irritation; cough to help you sleep; minor aches & pains; headache; fever; sore throat; runny nose & sneezing; reduces swelling of nasal passages; temporarily restores freer breathing through the nose; promotes nasal and/or sinus drainage.
- Do I need a prescription for Acetaminophen, dextromethorphan, doxylamine and phenylephrine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen, dextromethorphan, doxylamine and phenylephrine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
CVS NightTime Cold · Cvs Pharmacy
Acetaminophen 650 mg/30 mL · Dextromethorphan hydrobromide 20 mg/30 mL · Doxylamine succinate 12.5 mg/30 mL · Phenylephrine hydrochloride 10 mg/30 mL, solution (oral)
Active ingredient
Acetaminophen 650 mg Dextromethorphan HBr 20 mg Doxylamine succinate 12.5 mg Phenylephrine HCl 10 mg Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
temporarily relieves common cold/flu symptoms:
- nasal congestion
- sinus congestion & pressure
- cough due to minor throat & bronchial irritation
- cough to help you sleep
- minor aches & pains
- headache
- fever
- sore throat
- runny nose & sneezing
- reduces swelling of nasal passages
- temporarily restores freer breathing through the nose
- promotes nasal and/or sinus drainage
Warnings
Liver warning This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4 doses in 24 hours, which is the maximum daily amount for this product
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product Allergy Alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- Skin reddening
- Blisters
- Rash If a skin reaction occurs, stop use and seek medical help right away Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have
- liver disease
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- glaucoma
- cough that occurs with too much phlegm (mucus)
- a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
- trouble urinating due to enlarged prostate gland
- a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- you get nervous, dizzy or sleepless
- pain, nasal congestion, or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222 . Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only as directed
- only use the dose cup provided
- do not exceed 4 doses per 24 hrs
| adults & children 12 yrs & over | 30 mL every 4 hrs |
| children 4 to under 12 yrs | ask a doctor |
| children under 4 yrs | do not use |
Inactive ingredients
citric acid, D&C Yellow No. 10, disodium edetate, FD&C Blue No. 1, flavor, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium chloride, sodium citrate, sorbitol, sucralose
Questions?
1-866-467-2748
— FDA label of CVS NightTime Cold, Cvs Pharmacy, effective August 14, 2026. See the official label on DailyMed →
TopCare Nite Time SEVERE Cold and Flu · Topco Associates LLC
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg, capsule, liquid filled (oral)
Active ingredient (in each softgel)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Doxylamine succinate 6.25 mg Phenylephrine HCl 5 mg
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
- temporarily relieves common cold/flu symptoms:
- nasal congestion
- sinus congestion & pressure
- cough due to minor throat & bronchial irritation
- cough to help you sleep
- minor aches & pains
- headache
- fever
- sore throat
- runny nose & sneezing
- reduces swelling of nasal passages
- temporarily restores freer breathing through the nose
- promotes nasal and/or sinus drainage
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 8 softgels in 24 hours, which is the maximum daily amount for this product
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have
- liver disease
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- glaucoma
- a sodium-restricted diet
- trouble urinating due to enlarged prostate gland
- cough that occurs with too much phlegm (mucus)
- a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- you get nervous, dizzy or sleepless
- pain, nasal congestion, or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away.
Directions
take only as directed
- do not exceed 8 softgels per 24 hrs
| adults & children 12 yrs & over | 2 softgels with water every 4 hours |
| children 4 to under 12 yrs | ask a doctor |
| children under 4 yrs | do not use |
Inactive ingredients
edible printing ink, FD&C blue no. 1, gelatin, glycerin, polyethylene glycol 400, povidone K30, propylene glycol, purified water, sorbitol sorbitan solution
Questions?
Call 1-888-423-0139
— FDA label of TopCare Nite Time SEVERE Cold and Flu, Topco Associates LLC, effective November 3, 2023. See the official label on DailyMed →
Equate Nighttime Cold and Flu · Walmart Inc.
Acetaminophen 325 mg/15 mL · Dextromethorphan hydrobromide 10 mg/15 mL · Doxylamine succinate 6.25 mg/15 mL · Phenylephrine hydrochloride 5 mg/15 mL, solution (oral)
Active ingredient (in each 15 mL)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Doxylamine Succinate 6.25 mg Phenylephrine HCl 5 mg
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
temporarily relieves common cold/flu symptoms:
- nasal congestion
- sinus congestion and pressure
- cough due to minor throat and bronchial irritation
- cough to help you sleep
- minor aches and pains
- headache
- fever
- sore throat
- runny nose and sneezing
- reduces swelling of nasal passages
- temporarily restores freer breathing through the nose
- promotes nasal and/or sinus drainage
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if
- adult takes more than 4,000 mg of acetaminophen in 24 hours
- child takes more than 5 doses in 24 hours
- taken with other drugs containing acetaminophen
- adult has 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- to make a child sleepy
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- heart disease
- high blood pressure
- glaucoma
- thyroid disease
- diabetes
- cough that occurs with too much phlegm (mucus)
- trouble urinating due to an enlarged prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- you get nervous, dizzy or sleepless
- pain, nasal congestion, or cough gets worse or lasts more than 5 days (children) or 7 days (adults)
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only as directed – see Overdose warning
- only use the dose cup provided
- do not exceed 4 doses per 24 hrs
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Other information
- each 15 mL contains: sodium 15 mg
- store at 20-25°C (68-77°F)
Inactive ingredients
anhydrous citric acid, D&C yellow #10, edetate disodium, FD&C green #3, FD&C red #40, FD&C yellow #6, flavor, glycerin, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium benzoate, sodium chloride, sodium citrate, sorbitol solution, sucralose, xanthan gum
— FDA label of Equate Nighttime Cold and Flu, Walmart Inc., effective May 19, 2026. See the official label on DailyMed →
Equate Vapor Ice Cold and Flu · Wal-Mart Stores Inc
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Doxylamine succinate 6.25 mg Phenylephrine HCl 5 mg
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
- temporarily relieves common cold/flu symptoms:
- nasal congestion
- sinus congestion and pressure
- cough due to minor throat and bronchial irritation
- cough to help you sleep
- minor aches and pains
- headache
- fever
- sore throat
- runny nose and sneezing
- reduces swelling of nasal passages
- temporarily restores freer breathing through the nose
- promotes nasal and/or sinus drainage
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- glaucoma
- cough that occurs with too much phlegm (mucus)
- a breathing problem such as emphysema or chronic bronchitis
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
- trouble urinating due to an enlarged prostate gland
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- you get nervous, dizzy or sleepless
- pain, nasal congestion, or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
Directions
take only as directed – see overdose warning
- do not exceed 8 caplets per 24 hrs
| adults & children 12 yrs & over | 2 caplets with water every 4 hrs |
| children 4 to under 12 yrs | ask a doctor |
| children under 4 yrs | do not use |
Inactive ingredients
crospovidone, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, FD&C yellow #6 aluminum lake, flavor, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, pregelatinized starch, propylene glycol, silicon dioxide, stearic acid, sucralose, talc, titanium dioxide
Questions?
1-888-287-1915
— FDA label of Equate Vapor Ice Cold and Flu, Wal-Mart Stores Inc, effective November 14, 2025. See the official label on DailyMed →
Nighttime severe cold and flu · Target Corporation
Acetaminophen 650 mg/30 mL · Dextromethorphan hydrobromide 20 mg/30 mL · Doxylamine succinate 12.5 mg/30 mL · Phenylephrine hydrochloride 10 mg/30 mL, liquid (oral)
Active ingredient (in each 30 mL)
Acetaminophen 650 mg Dextromethorphan HBr 20 mg Doxylamine succinate 12.5 mg Phenylephrine HCl 10 mg
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
temporarily relieves common cold/flu symptoms: nasal congestion sinus congestion & pressure cough due to minor throat & bronchial irritation cough to help you sleep minor aches & pains headache fever sore throat runny nose & sneezing reduces swelling of nasal passages temporarily restores freer breathing through the nose promotes nasal and/or sinus drainage
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4 doses in 24 hours, which is the maximum daily amount for this product
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have
- liver disease
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- glaucoma
- cough that occurs with too much phlegm (mucus)
- a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
- trouble urinating due to enlarged prostate gland
- a sodium-restricted diet
Ask a doctor or pharmacist before use if
you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin.
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- you get nervous, dizzy or sleepless
- pain, nasal congestion, or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breastfeeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only as directed
- only use the dose cup provided
- do not exceed 4 doses per 24 hrs
| adults & children 12 yrs & over | 30 mL every 4 hrs |
| children 4 to under 12 yrs | ask a doctor |
| children under 4 yrs | do not use |
Other information
- each 30 mL contains: sodium 98 mg
- store at no greater than 25℃ and do not refrigerate
Inactive ingredients
citric acid monohydrate, FD&C blue no.1, FD&C red no. 40, flavor, glycerin, polyethylene glycol, propylene glycol, purified water, sodium benzoate, sodium chloride, sodium citrate, sodium saccharin, sorbitol solution, sucralose, xanthan gum
Questions?
Call 1-800-910-6874
— FDA label of Nighttime severe cold and flu, Target Corporation, effective July 11, 2024. See the official label on DailyMed →
Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION · The Procter & Gamble Manufacturing Company
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg, tablet, coated (oral)
Active ingredient (in each caplet)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Doxylamine succinate 6.25 mg Phenylephrine HCl 5 mg Purpose Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Purpose
Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant
Uses
temporarily relieves common cold/flu symptoms: nasal congestion sinus congestion & pressure cough due to minor throat & bronchial irritation cough to help you sleep minor aches & pains headache fever sore throat runny nose & sneezing reduces swelling of nasal passages temporarily restores freer breathing through the nose promotes nasal and/or sinus drainage
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 8 caplets in 24 hours, which is the maximum daily amount for this product with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy Alert: Acetaminophen may cause severe skin reactions. Symptoms may include: Skin reddening Blisters Rash If a skin reaction occurs, stop use and seek medical help right away Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have liver disease heart disease high blood pressure thyroid disease diabetes glaucoma cough that occurs with too much phlegm (mucus) a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema trouble urinating due to enlarged prostate gland
Ask a doctor or pharmacist before use if
you are taking sedatives or tranquilizers taking the blood thinning drug warfarin
When using this product
do not use more than directed excitability may occur, especially in children marked drowsiness may occur avoid alcoholic drinks be careful when driving a motor vehicle or operating machinery alcohol, sedatives, and tranquilizers may increase drowsiness
Stop use and ask a doctor if
you get nervous, dizzy or sleepless pain, nasal congestion, or cough gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only as directed do not exceed 8 caplets per 24 hrs
| adults & children 12 yrs & over | 2 caplets with water every 4 hrs |
| children 4 to under 12 yrs | ask a doctor |
| children under 4 yrs | do not use |
Inactive ingredients
crospovidone, D&C Yellow No. 10 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, FD&C Yellow No. 6 Aluminum Lake, flavor, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, pregelatinized starch, silicon dioxide, stearic acid, sucralose, talc, titanium dioxide
Questions?
1-800-362-1683
— FDA label of Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION, The Procter & Gamble Manufacturing Company, effective September 8, 2026. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 650 mg/30 mL · Dextromethorphan hydrobromide 20 mg/30 mL · Doxylamine succinate 12.5 mg/30 mL · Phenylephrine hydrochloride 10 mg/30 mL · solution (oral) · 33 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Basic Care Nighttime Severe Cold and Flu | Amazon.com Services LLC | DailyMed |
| CareOne Nighttime Severe Cold and Flu | American Sales Company | DailyMed |
| Cold and Flu plus Congestion Nighttime | Walmart Inc. | — |
| CVS NightTime Cold | Cvs Pharmacy | DailyMed |
| Dg Health Cold and Flu | Dolgencorp, LLC | DailyMed |
| Equaline Nighttime Severe Cold and Flu | United Natural Foods, Inc. dba UNFI | DailyMed |
| Equate Nighttime Cold and Flu | Wal-Mart Stores Inc | DailyMed |
| Good Sense Severe NightTime | L. Perrigo Company | DailyMed |
| Good Sense Severe NightTime Cold and Flu | L. Perrigo Company | DailyMed |
| Nighttime Severe | CVS Pharmacy | DailyMed |
| Nighttime Severe Cold and Flu | Amazon.com Services LLC | DailyMed |
| Nighttime Severe Cold and Flu | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| Nighttime Severe Cold and Flu | H E B | DailyMed |
| NightTime Severe Cold and Flu | Kroger Company | DailyMed |
| Nighttime Severe Cold and Flu Relief | Rite Aid Corporation | — |
| Nitetime Cold and Flu | Meijer Distribution Inc | DailyMed |
| Nitetime Severe | Publix Super Markets Inc | DailyMed |
| NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION | The Procter & Gamble Manufacturing Company | — |
| Severe Cold and Flu | HyVee Inc | DailyMed |
| Severe Cold and Flu | Walgreen Company | DailyMed |
| Severe Cold and Flu Night time | HyVee Inc | DailyMed |
| Severe Cold and Flu Relief | Rite Aid Corporation | DailyMed |
| Severe Nighttime | CVS Pharmacy | DailyMed |
| Signature Care Nighttime Severe Cold and Flu Relief | Safeway | DailyMed |
| Topcare Nite Time Cold and Flu | Topco Associates LLC | DailyMed |
Showing 25 of 27 brands.
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · capsule, liquid filled (oral) · 29 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | Softgel Healthcare Private Limited | DailyMed |
| Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate and Phenylephrine Hydrochloride | Softgel Healthcare Pvt Ltd | DailyMed |
| ALKA SELTZER COLD Cold and Allergy Maximum Strength Fast Gels | Bayer HealthCare LLC. | DailyMed |
| ALKA SELTZER COLD Cold Flu and Congestion Severe Night Fast Gels | Bayer HealthCare LLC. | DailyMed |
| Alka Seltzer Plus Maximum Strength Sinus, Allergy And Cough Power Max Gels | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Maximum Strength Night Cold and Flu | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Maximum Strength Night Cold and Flu PowerMax Gels | Bayer HealthCare LLC. | DailyMed |
| Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough | Bayer HealthCare LLC. | DailyMed |
| ASP Nighttime Max | Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. | DailyMed |
| Cold and Flu Nighttime Severe | Target Corp | DailyMed |
| equate MAXIMUM STRENGTH NIGHTTIME SEVERE Cold and Flu SOFTGELS | Walmart Inc. | DailyMed |
| HyVee Nighttime Severe Cold and Flu SOFTGEL | HyVee Inc | DailyMed |
| Maximum Strength Nighttime Severe Cold and Flu | Prodose, Inc. | DailyMed |
| Maximum Strenth Night Cold and Flu Formula | Family Dollar | DailyMed |
| Night Cold Flu Cough and Allergy | Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. | DailyMed |
| Night Time Cold and Flu | Retail Business Services, LLC | DailyMed |
| Night Time Severe Cold and Flu Relief | PuraCap Pharmaceutical LLC | DailyMed |
| NIGHTTIME COLD AND FLU Maximum Strength | Walgreens | DailyMed |
| Nighttime Severe Cold and Flu | Kroger | DailyMed |
| Nighttime Severe Cold and Flu | Wal-Mart Stores Inc | DailyMed |
| Nighttime Severe Cold and Flu Maximum Strength mini softgels | Shield Pharmaceuticals Corp | DailyMed |
| NiteTime SEVERE Cold and Flu Relief SOFTGELS | Topco Associates LLC | DailyMed |
| QUALITY CHOICE Maximum Strength Nighttime Cold and Flu | Chain Drug Marketing Association, Inc. | DailyMed |
| QUALITY CHOICE NightTime Severe Cold and Flu | Chain Drug Marketing Association, Inc. | DailyMed |
| RIGHT REMEDIES NIGHTTIME SEVERE COLD AND FLU softgel | Strive Pharmaceuticals Inc. | DailyMed |
Showing 25 of 28 brands.
Acetaminophen 325 mg/15 mL · Dextromethorphan hydrobromide 10 mg/15 mL · Doxylamine succinate 6.25 mg/15 mL · Phenylephrine hydrochloride 5 mg/15 mL · solution (oral) · 14 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Basic Care Nighttime Severe Cold and Flu | Amazon.com Services LLC | DailyMed |
| DG Health Cold and Flu Severe | Dolgencorp Inc | DailyMed |
| Equate Nighttime Cold and Flu | Walmart Inc. | DailyMed |
| Foster and Thrive Nighttime Severe Cold and Flu Relief | Strategic Sourcing Services LLC | DailyMed |
| Good Sense Night Time Cold and Flu | L. Perrigo Company | DailyMed |
| Night Time Cold and Flu | Meijer, Inc. | DailyMed |
| Nighttime Severe | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| Nighttime SEVERE | H E B | DailyMed |
| Nighttime Severe Cold and Flu | Walgreen Company | DailyMed |
| Severe Cold and Flu | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| Severe Cold and Flu | HyVee Inc | DailyMed |
| Severe Cold and Flu Relief | Rite Aid Corporation | DailyMed |
| Topcare Nite Time Cold and Flu | Topco Associates LLC | DailyMed |
| Tylenol Cold plus Flu plus Cough Night | Kenvue Brands LLC | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · tablet, film coated (oral) · 9 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Basic Care Nighttime Severe Cold and Flu | Amazon.com Services LLC | DailyMed |
| Cold and Flu Nighttime Severe | L.N.K. International, Inc. | DailyMed |
| Cold and Flu Nighttime Severe | Lil' Drug Store Products, Inc. | DailyMed |
| Cold and Flu Nighttime Severe, 24-7 Life | Lil' Drug Store products, Inc. | DailyMed |
| Equate Vapor Ice Cold and Flu | Wal-Mart Stores Inc | DailyMed |
| Nighttime Severe, Cold and Flu, 24-7 Life by 7-Eleven | Lil' Drug Store Products, Inc. | DailyMed |
| Nite time Severe Cold and Flu Maximum Strength | Meijer Distribution Inc | DailyMed |
| Severe Nighttime Cold and Flu Relief | Rite Aid Corporation | — |
| Topcare Nite Time Cold and Flu | Topco Associates LLC | DailyMed |
Acetaminophen 650 mg/30 mL · Dextromethorphan hydrobromide 20 mg/30 mL · Doxylamine succinate 12.5 mg/30 mL · Phenylephrine hydrochloride 10 mg/30 mL · liquid (oral) · 9 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Night Time Severe Cold and Flu | Walgreen Company | DailyMed |
| Nighttime Severe Cold and Flu | Grocery Outlet, Inc. | DailyMed |
| Nighttime Severe Cold and Flu | Kroger | DailyMed |
| Nighttime severe cold and flu | Target Corporation | DailyMed |
| Rompe Pecho Nighttime | Efficient Laboratories Inc | DailyMed |
| Severe cold and flu Nighttime | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | — |
| Severe cold and flu Nighttime | P & L Development, LLC | DailyMed |
| Severe Nighttime Cold and Flu Relief | Family Dollar (FAMILY WELLNESS) | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · tablet, coated (oral) · 5 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| NyQuil Severe Plus VapoCOOL Cold and Flu | Lil' Drug Store Products, Inc. | DailyMed |
| NyQuil Severe Plus VapoCOOL Cold and Flu, CVP HEALTH | Lil' Drug Store Products, Inc. | DailyMed |
| NyQuil Severe Plus VapoCOOL Cold and Flu, TRAVEL BASIX | Lil' Drug Store Products, Inc. | DailyMed |
| NyQuil Severe plus Vicks VapoCool Cold and Flu | The Procter & Gamble Manufacturing Company | DailyMed |
| Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION | The Procter & Gamble Manufacturing Company | DailyMed |
Acetaminophen 325 mg/15 mL · Dextromethorphan hydrobromide 10 mg/15 mL · Doxylamine succinate 6.25 mg/15 mL · Phenylephrine hydrochloride 5 mg/15 mL · liquid (oral) · 4 products
| Brand or product name | Company on the label | Label |
|---|---|---|
| Nighttime Severe Honey Cold and Flu | Target Corporation | DailyMed |
| Severe Cold and Flu Nighttime Honey | Kroger | DailyMed |
| Vicks NyQuil Severe Honey Cold and Flu | Procter & Gamble Manufacturing Company | — |
| VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU | Procter & Gamble Manufacturing Company | — |
Acetaminophen 650 mg · Dextromethorphan hydrobromide 20 mg · Doxylamine succinate 12.5 mg · Phenylephrine hydrochloride 10 mg · powder, for solution (oral) · 2 products
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · capsule, gelatin coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Severe Nighttime Cold and Flu | Walgreens | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 15 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 6.25 mg · capsule, liquid filled (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Nighttime Cold and Flu Max Softgels | Topco Associates, LLC | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 15 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · capsule, liquid filled (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Nighttime Cold and Flu Mini Softgels | Shield Pharmaceuticals Corp | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · capsule (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Nighttime Severe Cold and Flu | Cvs Health Corp | DailyMed |
Acetaminophen 650 mg/15 mL · Dextromethorphan hydrobromide 20 mg/15 mL · Doxylamine succinate 12.5 mg/15 mL · Phenylephrine hydrochloride 10 mg/15 mL · solution (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Onessip Adult Nighttime Severe Cold and Flu | Medwise Lifesciences Inc. | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Doxylamine succinate 6.25 mg · Phenylephrine hydrochloride 5 mg · powder, for solution (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| ANTIGRIP Nighttime | Pharmadel LLC | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| acetaminophen 650 mg/30 mL · dextromethorphan hydrobromide 20 mg/30 mL · doxylamine succinate 12.5 mg/30 mL · phenylephrine hydrochloride 10 mg/30 mL solution | Generic | $0.0097 per mL |
NADAC list of November 4, 2026; these prices took effect on September 23, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Bayer HealthCare LLC.8 products
- Amazon.com Services LLC6 products
- Lil' Drug Store Products, Inc.6 products
- Topco Associates LLC6 products
- The Procter & Gamble Manufacturing Company6 products
- Rite Aid Corporation4 products
- Cvs Woonsocket Prescription Center, Incorporated4 products
- Walgreen Company4 products
- HyVee Inc4 products
- Walmart Inc.3 products
- Kroger3 products
- L. Perrigo Company3 products
- Shield Pharmaceuticals Corp3 products
- Meijer Distribution Inc3 products
- CVS Pharmacy3 products
- Wal-Mart Stores Inc3 products
- Chain Drug Marketing Association, Inc.2 products
- H E B2 products
- Target Corporation2 products
- P & L Development, LLC2 products
- PuraCap Pharmaceutical LLC2 products
- Walgreens2 products
- Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.2 products
- Procter & Gamble Manufacturing Company2 products
- Softgel Healthcare Pvt Ltd1 product
- United Natural Foods, Inc. dba UNFI1 product
- Retail Business Services, LLC1 product
- Meijer, Inc.1 product
- Kenvue Brands LLC1 product
- Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)1 product
Showing the 30 companies with the most products, of 50.
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.