Quick answers
- What is Acetaminophen, dextromethorphan and triprolidine used for?
- The Drug Facts label of Overnight Cold and Flu (Raritan Pharmaceuticals) lists these uses: temporarily relieves these common cold and flu symptoms; cough; minor aches and pains; sore throat; headache; runny nose; sneezing; itching of the nose or throat; itchy, watery eyes due to hay fever; temporarily reduces fever; controls cough to help you get to sleep.
- Do I need a prescription for Acetaminophen, dextromethorphan and triprolidine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen, dextromethorphan and triprolidine been recalled?
- FDA enforcement reports list 1 recall of products on this page; the newest started April 15, 2015. A recall usually concerns specific products or lots, not every brand.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Overnight Cold and Flu · Raritan Pharmaceuticals
Acetaminophen 650 mg/20 mL · Dextromethorphan hydrobromide 20 mg/20 mL · Triprolidine hydrochloride 2.5 mg/20 mL, solution (oral)
Active ingredient (in each 20 mL)
Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine
Purpose
Active ingredients (in each 20 mL) Purposes Acetaminophen 650 mg Pain reliever/fever reducer Dextromethorphan HBr 20 mg Cough suppressant Triprolidine HCl 2.5 mg Antihistamine
Uses
- temporarily relieves these common cold and flu symptoms:
- cough
- minor aches and pains
- sore throat
- headache
- runny nose
- sneezing
- itching of the nose or throat
- itchy, watery eyes due to hay fever
- temporarily reduces fever
- controls cough to help you get to sleep
Warnings
Liver warning This product contains acetaminophen. Severe liver damage may occur if you take:
- more than 4000 mg in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks daily while using this product Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have
- liver disease
- glaucoma
- trouble urinating due to an enlarged prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
- cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- alcohol, sedatives, and tranquilizers may increase drowsiness
- avoid alcoholic drinks
- use caution when driving a motor vehicle or operating machinery
Stop use and ask a doctor if
- pain or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
Overdose warning Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed (see Overdose warning )
- do not take more than 4 doses in any 24-hour period
- measure only with dosing cup provided
- do not use dosing cup with other products
- dose as follows or as directed by a doctor
- adults and children 12 years of age and older: 20 mL in dosing cup provided every 4 hours
- children under 12 years of age: do not use
Inactive ingredients
anhydrous citric acid, ascorbic acid, edetate disodium, FD&C Blue No. 1, FD&C Red No. 40, flavors, glycerin, propyl gallate, propylene glycol, purified water, sodium benzoate, sodium citrate, sorbitol, sucralose, xanthan gum
Questions?
1-866-467-2748
— FDA label of Overnight Cold and Flu, Raritan Pharmaceuticals, effective September 8, 2026. See the official label on DailyMed →
Mucinex Nightshift Sinus Maximum Strength · RB Health (US) LLC
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Triprolidine hydrochloride 1.25 mg, tablet, coated (oral)
Active ingredient (in each caplet)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Triprolidine HCl 1.25 mg
Purpose
Acetaminophen 325 mg ........ Pain reliever/fever reducer Dextromethorphan HBr 10 mg................Cough suppressant Triprolidine HCl 1.25 mg...................................Antihistamine
Uses
- temporarily relieves these common cold and flu symptoms:
- cough
- minor aches and pains
- sore throat
- headache
- runny nose
- sneezing
- itching of the nose or throat
- itchy, watery eyes due to hay fever
- temporarily reduces fever
- controls cough to help you get to sleep
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:
- more than 8 caplets in 24 hours, which is the maximum daily amount for this product
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks daily while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if
you have
- liver disease
- glaucoma
- trouble urinating due to an enlarged prostate gland
- a breathing problem such as emphysema or chronic bronchitis
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
- cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- do not use more than directed
- excitability may occur, especially in children
- marked drowsiness may occur
- alcohol, sedatives, and tranquilizers may increase drowsiness
- avoid alcoholic drinks
- use caution when driving amotor vehicle or operatingmachinery
Stop use and ask a doctor if
- pain or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
- Overdose warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Keep out of reach of children
Directions
- do not take more than directed (see Overdose warning)
- do not take more than 8 caplets in any 24-hour period
- adults and children 12 years of age and over: take 2 caplets every 4 hours
- children under 12 years of age: do not use
Other information
- store at 20-25°C (68-77°F)
Inactive ingredients
croscarmellose sodium, crospovidone, hypromellose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, titanium dioxide
Questions?
1-866-MUCINEX (1-866-682-4639)
— FDA label of Mucinex Nightshift Sinus Maximum Strength, RB Health (US) LLC, effective May 15, 2025. See the official label on DailyMed →
Mucinex Childrens Night Time Multi-Symptom Cold and Flu · Reckitt Benckiser LLC
Acetaminophen 325 mg/10 mL · Dextromethorphan hydrobromide 10 mg/10 mL · Triprolidine hydrochloride 1.25 mg/10 mL, solution (oral)
Active ingredient (in each 10 mL)
Acetaminophen 325 mg Dextromethorphan HBr 10 mg Triprolidine HCl 1.25 mg Acetaminophen 325 mg - Pain reliever/fever reducer Dextromethorphan HBr 10 mg - Cough suppressant Triprolidine HCl 1.25 mg.........................Antihistamine
Purpose
Acetaminophen 325 mg - Pain reliever/fever reducer Dextromethorphan HBr 10 mg - Cough suppressant Triprolidine HCl 1.25 mg.........................Antihistamine
Uses
- temporarily relieves these common cold and flu symptoms:
- cough
- minor aches and pains
- sore throat
- headache
- runny nose
- sneezing
- itching of the nose or throat
- itchy, watery eyes due to hay fever
- temporarily reduces fever
- controls cough to help your child get to sleep
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if your child takes:
- more than 4 doses (40 mL) in 24 hours, which is the maximum daily amount for this product
- with other drugs containing acetaminophen
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- to make a child sleepy
- in a child who is taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your child’s prescription drug contains an MAOI, ask a doctor or pharmacist before giving this product.
Ask a doctor before use if
the child has
- liver disease
- glaucoma
- a breathing problem such as chronic bronchitis
- persistent or chronic cough such as occurs with asthma
- cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist before use if
the child is
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- do not use more than directed (see Overdose warning)
- excitability may occur, especially in children
- marked drowsiness may occur
- sedatives and tranquilizers may increase drowsiness
Stop use and ask a doctor if
- pain or cough gets worse or lasts more than 5 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
Keep out of reach of children
Overdose warning : Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for children even if you do not notice any signs or symptoms.
Keep out of reach of children
Directions
- this product does not contain directions or complete warnings for adult use
- do not give more than directed (see Overdose warning)
- measure only with dosing cup provided
- do not use dosing cup with other products
- dose as follows or as directed by a doctor
- children 6 to under 12 years of age: 10 mL in dosing cup provided every 4 hours while symptoms last; do not give more than 4 doses in any 24-hour period
- children under 6 years of age: do not use
Other information
- each 10 mL contains: sodium 6 mg
- store at 20-25ºC (68-77ºF)
- do not refrigerate
Inactive ingredients
ammonium glycyrrhizate, anhydrous citric acid, edetate disodium, FD&C red no. 40, FD&C yellow no. 10, flavors, glycerin (soy), propylene glycol, purified water, sodium benzoate, sorbitol, sucralose, xanthan gum
Questions?
1-866-MUCINEX (1-866-682-4639)
— FDA label of Mucinex Childrens Night Time Multi-Symptom Cold and Flu, Reckitt Benckiser LLC, effective May 21, 2026. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 650 mg/20 mL · Dextromethorphan hydrobromide 20 mg/20 mL · Triprolidine hydrochloride 2.5 mg/20 mL · solution (oral) · 12 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Cold and Flu Nighttime | Cvs Woonsocket Prescription Center, Incorporated | DailyMed |
| Cold and Flu Nighttime | Walgreen Company | DailyMed |
| Cold and Flu Nighttime | Walmart Inc. | DailyMed |
| CVS Nighttime Cold and Flu | Cvs Health | DailyMed |
| Delsym Nighttime Cough | Reckitt Benckiser LLC | DailyMed |
| Meijer Nighttime Cold and Flu | Meijer Distribution Inc. | — |
| Mucinex Fast-Max Nighttime Cold and Flu | Reckitt Benckiser LLC | — |
| Mucinex Fast-Max Recharge Nighttime Cold and Flu | Reckitt Benckiser LLC | DailyMed |
| Mucinex Nightshift Cold and Flu | Reckitt Benckiser LLC | — |
| Overnight Cold and Flu | Raritan Pharmaceuticals | DailyMed |
| Overnight Cold and Flu | Walgreens Co | DailyMed |
| Target Overnight Cold and Flu | Target Corporation | DailyMed |
Acetaminophen 325 mg · Dextromethorphan hydrobromide 10 mg · Triprolidine hydrochloride 1.25 mg · tablet, coated (oral) · 3 products
Acetaminophen 325 mg/10 mL · Dextromethorphan hydrobromide 10 mg/10 mL · Triprolidine hydrochloride 1.25 mg/10 mL · solution (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Mucinex Childrens Night Time Multi-Symptom Cold and Flu | Reckitt Benckiser LLC | DailyMed |
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Reckitt Benckiser LLC7 products
- Walmart Inc.1 product
- Walgreens Co1 product
- Walgreen Company1 product
- Meijer Distribution Inc.1 product
- Target Corporation1 product
- Cvs Woonsocket Prescription Center, Incorporated1 product
- Raritan Pharmaceuticals1 product
- Cvs Health1 product
- RB Health (US) LLC1 product
Recalls
From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific products or lots: check the name and lot number on your package.
-
April 15, 2015 · Class II · Terminated · D-1369-2015
Labeling: Label Mix-Up; Bottles of Mucinex Fast-Max liquid are correctly labeled on the front of the label, however the back of the bottle where the Drug Facts labeling is, is missing certain Active Ingredients such as acetaminophen, phenylephrine, dextromethorphan, diphenhydramine, and/or guaifenesin. As a result cert
Mucinex Fast Max DM Max, Maximum Strength, Dextromethorphan HBr Cough Suppressant, 6 fl oz (180 mL) Bottle, For Ages 12+, Dist. By: Reckitt Benckiser Parsippany, NJ 07054-0224 Made in India, NDC 63824-019-66, UPC 63824-0 — Reckitt Benckiser LLC
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.