Quick answers
- What is Acetaminophen, aspirin and caffeine used for?
- The Drug Facts label of Excedrin Migraine (Haleon US Holdings LLC) lists these uses: treats migraine.
- Do I need a prescription for Acetaminophen, aspirin and caffeine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen, aspirin and caffeine been recalled?
- FDA enforcement reports list 2 recalls of products on this page; the newest started July 11, 2024. A recall usually concerns specific products or lots, not every brand.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Excedrin Migraine · Haleon US Holdings LLC
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Acetaminophen 250 mg Aspirin 250 mg (NSAID*) Caffeine 65 mg * nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever Pain reliever aid
Uses
- treats migraine
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 2 caplets in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Medication overuse headache warning: Headaches may worsen if this product is used for 10 or more days per month. Caffeine warning : The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
Do not use
- if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist Ask doctor before use if
- you have never had migraines diagnosed by a health professional
- you have a headache that is different from your usual migraines
- you have the worst headache of your life
- you have fever and stiff neck
- you have headaches beginning after or caused by head injury, exertion, coughing or bending
- you experienced your first headache after the age of 50
- you have daily headaches
- you have a migraine so severe as to require bed rest
- you have liver disease
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
- you have problems or serious side effects from taking pain relievers or fever reducers
- you have vomiting with your migraine headache
Ask a doctor or pharmacist before use if
you are
- taking a prescription drug for:
- diabetes
- gout
- arthritis
- under a doctor’s care for any serious condition
- taking any other drug
- taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- your migraine is not relieved or worsens after first dose
- new or unexpected symptoms occur
- ringing in the ears or loss of hearing occurs
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not use more than directed
- adults: take 2 caplets with a glass of water
- if symptoms persist or worsen, ask your doctor
- do not take more than 2 caplets in 24 hours, unless directed by a doctor
- under 18 years of age: ask a doctor
Inactive ingredients
benzoic acid, carnauba wax, FD&C blue #1, hydroxypropylcellulose, hypromellose, light mineral oil, microcrystalline cellulose, polysorbate 20, povidone, propylene glycol, simethicone emulsion, sorbitan monolaurate, stearic acid, titanium dioxide
Questions?
1-800-468-7746
— FDA label of Excedrin Migraine, Haleon US Holdings LLC, effective June 25, 2025. See the official label on DailyMed →
Migraine Relief · Harris Teeter
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg, tablet (oral)
Active ingredient (s)
Acetaminophen 250 mg Aspirin 250 mg (NSAID*) Caffeine 65 mg *nonsteroidal anti-inflammatory drug Purpose Pain reliever Pain reliever Pain reliver aid
Purpose
Pain reliever Pain reliever Pain reliver aid
Uses
- treats migraine
Warnings
Reye's syndrome Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away. Allergy alert Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock Liver warning This product contains acetaminophen. Severe liver damage may occur if you take
- more than 2 caplets in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed Medication overuse headache warning Headaches may worsen if this product is used for 10 or more days per month. Caffeine warning The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.
Do not use
- if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
Ask a doctor before use if
- you have never had migraines diagnosed by a health professional
- you have a headache that is different from your usual migraines
- you have the worst headache of your life
- you have fever and stiff neck
- you have headaches beginning after or caused by head injury, exertion, coughing or bending
- you experienced your first headache after the age of 50
- you have daily headaches
- you have a migraine so severe as to require bed rest
- you have liver disease
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
- you have problems or serious side effects from taking pain relievers or fever reducers
- you have vomiting with your migraine headache
Ask a doctor or pharmacist before use if
you are
- taking a prescription drug for:
- diabetes
- gout
- arthritis
- under a doctor’s care for any serious condition
- taking any other drug
- taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- your migraine is not relieved or worsens after first dose
- new or unexpected symptoms occur
- ringing in the ears or loss of hearing occurs
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not use more than directed
- adults: take 2 caplets with a glass of water
- if symptoms persist or worsen, ask your doctor
- do not take more than 2 caplets in 24 hours, unless directed by a doctor
- under 18 years of age: ask a doctor
Inactive ingredients
carnauba wax, hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, polyethylene glycol, sodium stearyl fumarate, titanium dioxide
Questions?
1-844-705-4384
— FDA label of Migraine Relief, Harris Teeter, effective August 5, 2026. See the official label on DailyMed →
Walgreens Headache Relief Extra Strength · Walgreens
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg, tablet, coated (oral)
Active ingredient (in each softgel)
Acetaminophen 250 mg Aspirin 250 mg (NSAID)* Caffeine 65 mg *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever Pain reliever aid
Uses
Temporarily relieves minor aches and pains due to:
- headache
- a cold
- arthritis
- muscular aches
- toothache
- premenstrual and menstrual cramps
Warnings
- Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness.
- Allergy alert: Acetaminophen may cause skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 8 geltabs in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDS (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasional rapid heartbeat.
Do not use
- if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription). if you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have a history of stomach problems such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
Ask a doctor or pharmacist before use if
you are taking
Ask a doctor or pharmacist before use if
you are taking
- a prescription drug for diabetes, gout, or arthritis
- any other drug, or are under a doctor's care for any serious condition
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- ringing in the ears or loss of hearing occurs
- painful area is red or swollen
- pain gets worse or lasts for more than 10 days
- fever gets worse or lasts for more than 3 days
- any new symptoms occur These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as children even if you do not notice any signs or symptoms.
Directions
- do not use more than directed (see overdose warning)
- drink a full glass of water with each dose
- adults and children 12 years and over: take 2 geltabs every 6 hours; not more than 8 geltabs in 24 hours
- children under 12 years: ask a doctor
Other information
- store at room temperature between 20-25°C (68-77°F)
- avoid excessive heat, cold and humidity
Inactive ingredients
corn starch, D&C yellow #10 aluminum lake, edible black ink, ethyl cellulose, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, gelatin, glycerin, hypromellose, isopropyl alcohol, lactose monohydrate, light mineral oil, microcrystalline cellulose, pregelatinized potato starch, purified water, pvpk-30, sorbitol sorbitan solution, stearic acid, talc, titanium dioxide, triacetin
Questions?
1-888-333-9792 Monday-Friday 8am-4pm EST
— FDA label of Walgreens Headache Relief Extra Strength, Walgreens, effective May 18, 2026. See the official label on DailyMed →
GOODYS Extra Strength Headache Mixed Fruit Blast · Medtech Products Inc.
Acetaminophen 325 mg · Aspirin 500 mg · Caffeine 65 mg, powder (oral)
Active ingredient (in each powder )
Acetaminophen 325 mg Aspirin (NSAID*) 500 mg Caffeine 65 mg *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever Pain reliever aid
Uses
Temporarily relieves minor aches and pains due to:
- headache
- minor arthritis pain
- muscular aches
- a cold
- backache
- toothache
- menstrual cramps
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy Alert: Aspirin may cause severe allergic reaction which may include:
- hives
- facial swelling
- shock
- asthma (wheezing). Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash. If a skin reaction occurs, stop use and seek medical help right away.
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4 packs in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Stomach bleeding warning: This product contains a NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or non-prescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed. Caffeine warning : This product contains caffeine. Limit the use of caffeine-containing medications, foods, or beverages because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
Do not use
- if you have ever had an allergic reaction to aspirin or any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
Ask a doctor or pharmacist before use if
you are taking
- a prescription drug for diabetes, gout, or arthritis
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stool
- have stomach pain that does not get better
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- any new symptoms appear
- ringing in the ears or a loss of hearing occurs These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
- Overdose warning: Taking more than the recommended dose can cause serious health problems. In case of overdose, get medical help or contact Poison Control Center (1-800-222-1222) right away. Quick medical attention is critical for adults as well as children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed (see overdose warning )
- a dults and children 12 years and over: open 1 pack,place powder on tongue every 6 hours, while symptoms persist. Drink a full glass of water with each dose, or may stir powder into a glass of water or other liquid.
- do not take more than 4 packs in 24 hours unless directed by a doctor.
- c hildren under 12 years of age: ask a doctor.
Other information
- store below 25°C (77°F)
Inactive ingredients
colloidal silicon dioxide, flavors, guar gum, mannitol, microcrystalline cellulose, sucralose
Questions?
1-866-255-5197 goodyspowder.com
— FDA label of GOODYS Extra Strength Headache Mixed Fruit Blast, Medtech Products Inc., effective October 23, 2025. See the official label on DailyMed →
Goodys Extra Strength · Medtech Products Inc.
Acetaminophen 260 mg · Aspirin 520 mg · Caffeine 32.5 mg, powder (oral)
Active ingredient (in each powder)
Acetaminophen 260 mg Aspirin (NSAID*) 520 mg Caffeine 32.5 mg *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever Pain reliever aid
Uses
Temporarily relieves minor aches and pains due to: headache
- minor arthritis pain muscle aches
- a cold menstrual cramps toothache
Warnings
- Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy Alert: Aspirin may cause severe allergic reaction which may include:
- hives facial swelling
- shock
- asthma (wheezing). Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash. If a skin reaction occurs, stop use and seek medical help right away.
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4 packs in 24 hours, which is the maximum daily amount with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or non-prescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed. Caffeine warning : This product contains caffeine. Limit the use of caffeine-containing medications, foods, or beverages because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
Do not use
if you have ever had an allergic reaction to aspirin or any other pain reliever/fever reducer with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use if
you have liver disease stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma
Ask a doctor or pharmacist before use if
you are taking a prescription drug for diabetes, gout, or arthritis
Stop use and ask a doctor if
an allergic reaction occurs. Seek medical help right away you experience any of the following signs of stomach bleeding
- feel faint
- vomit blood
- have bloody or black stool
- have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present any new symptoms appear ringing in the ears or a loss of hearing occurs These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. K eep out of reach of children.
- Overdose warning: Taking more than the recommended dose can cause serious health problems. In case of overdose, get medical help or contact Poison Control Center (1-800-222-1222) right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
do not take more than directed (see overdose warning) adults and children 12 years and over: Open 1 pack. place powder on tongue every 6 hours, while symptoms persist. Drink a full glass of water with each dose or may stir powder into a glass of water or other liquid. do not take more than 4 packs in 24 hours unless directed by a doctor. Children under 12 years of age: ask a doctor.
Other information
each powder contains: potassium 51 mg store below 25°C (77°F)
Inactive ingredients
lactose monohydrate, potassium chloride
Questions?
1-866-255-5197 weekdays or goodyspowder.com
— FDA label of Goodys Extra Strength, Medtech Products Inc., effective October 23, 2025. See the official label on DailyMed →
Acetaminophen , Aspirin and Caffeine · Softgel Healthcare Pvt Ltd
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg, capsule (oral)
Active ingredient (in each geltab)
Acetaminophen 250 mg Aspirin 250 mg Caffeine 65 mg
Purpose
Pain reliever Pain reliever Pain reliever aid
Uses
Temporarily relieves minor aches and pains due to:
- headache
- a cold
- arthritis
- muscular aches
- toothache
- premenstrual and menstrual cramps
Warnings
Reye's syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product
if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness.
- Allergy alert: Acetaminophen may cause skin reactions.Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away. Allergy alert : Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 8 geltabs in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDS (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed Caffeine warning : The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasional rapid heartbeat.
Do not use
- if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription). if you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have a history of stomach problems such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have asthma
Ask a doctor or pharmacist before use if
you are taking
- a prescription drug for diabetes, gout, or arthritis
- any other drug, or are under a doctor's care for any serious condition
Stop use and ask a doctor if
- an allergic reaction occurs. Seek medical help right away.
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- ringing in the ears or loss of hearing occurs
- painful area is red or swollen
- pain gets worse or lasts for more than 10 days
- fever gets worse or lasts for more than 3 days
- any new symptoms occur These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as children even if you do not notice any signs or symptoms.
Directions
- do not use more than directed (see overdose warning)
- drink a full glass of water with each dose
- adults and children 12 years and over: take 2 geltabs every 6 hours; not more than 8 geltabs in 24 hours
- children under 12 years: ask a doctor
Other information
- store at room temperature between 20-25°C(68-77°F)
- avoid excessive heat, cold and humidity
Inactive ingredients
corn starch, D&C yellow #10 aluminum lake, edible black ink, ethyl cellulose, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, gelatin, glycerin, hypromellose, isopropyl alcohol, lactose monohydrate, light mineral oil, microcrystalline cellulose, pregelatinized potato starch, purified water, pvpk-30, sorbitol sorbitan solution, stearic acid, talc, titanium dioxide, triacetin.
— FDA label of Acetaminophen , Aspirin and Caffeine, Softgel Healthcare Pvt Ltd, effective April 27, 2026. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg · tablet, film coated (oral) · 95 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Excedrin Migraine | A-S Medication Solutions | DailyMed |
| Excedrin Migraine | Haleon US Holdings LLC | DailyMed |
| Excedrin Migraine | Lil' Drug Store Products, Inc. | DailyMed |
| Excedrin Migraine | Navajo Manufacturing Company Inc. | DailyMed |
| Excedrin Migraine | Select Consumer Group | — |
| Excedrin Migraine Relief | Haleon US Holdings LLC | DailyMed |
| Excedrin Migraine, CVP HEALTH | Lil' Drug Store Products, Inc. | DailyMed |
| Excedrin Migraine, TRAVEL BASIX | Lil' Drug Store Products, Inc. | DailyMed |
| Acetaminophen Aspirin and Caffeine | Aurohealth LLC | DailyMed |
| Acetaminophen Aspirin and Caffeine | Better Living Brands, LLC | DailyMed |
| Acetaminophen Aspirin and Caffeine | Walmart Inc. | DailyMed |
| Acetaminophen, Aspirin, Caffeine | CVS Pharmacy, Inc. | DailyMed |
| Acetaminophen, Aspirin, Caffeine | LEADER/ Cardinal Health 110, Inc. | DailyMed |
| Acetaminophen, Aspirin, Caffeine | NuCare Pharmaceuticals, Inc. | DailyMed |
| Acetaminophen, Aspirin, Caffeine | Proficient Rx LP | DailyMed |
| Amazon Basic Care Migraine Relief | Amazon.com Services LLC | — |
| Arthriten Inflammatory Pain Formula | Kobayashi Healthcare International, Inc | DailyMed |
| Basic Care Headache Relief | Amazon.com Services LLC | DailyMed |
| Basic Care Migraine Relief | Amazon.com Services LLC | DailyMed |
| Care One migraine relief | American Sales Company | DailyMed |
| Dg Health Migraine Relief | Dolgencorp Inc | DailyMed |
| DG Health migraine relief | Dolgencorp, LLC | DailyMed |
| DRX CHOICE Extra Strength Headache Relief | Raritan Pharmaceuticals Inc. | — |
| Equaline migraine formula | United Natural Foods, Inc. dba UNFI | DailyMed |
| Exaprin Plus | HART Health | DailyMed |
Showing 25 of 82 brands.
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg · tablet (oral) · 61 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen 250mg Aspirin 250mg Caffeine 65mg | CVS Pharmacy | DailyMed |
| Acetaminophen 250mg Aspirin 250mg Caffeine 65mg | Walgreens Co. | DailyMed |
| Acetaminophen Aspirin Caffeine | Cvs Pharmacy, Inc | DailyMed |
| Acetaminophen Aspirin Caffeine | Dr. Reddy's Laboratories Inc. | — |
| Acetaminophen Aspirin Caffeine | Walgreen Co | DailyMed |
| Acetaminophen, Aspirin and Caffeine | Family Dollar | DailyMed |
| Acetaminophen, Aspirin and Caffeine | Granules India Ltd | — |
| Acetaminophen, Aspirin and Caffeine | Rising Pharma Holdings, Inc. | DailyMed |
| Acetaminophen, Aspirin and Caffeine | Safeway, Inc | DailyMed |
| Acetaminophen, Aspirin and Caffeine | Safrel Pharmaceuticals, LLC. | DailyMed |
| Acetaminophen, Aspirin, and Caffeine | Bi-Mart | DailyMed |
| Agrifen | Opmx LLC | DailyMed |
| Artrifin 24 Caplets | Opmx LLC | DailyMed |
| BioElectro Extra Strength Headache Relief | Genomma Lab USA | DailyMed |
| Dolex Forte | Pharmadel LLC | DailyMed |
| Dolodol | Opmx LLC | — |
| Extra Strenght Headache Relief | Lil' Drug Store Products, Inc. | DailyMed |
| Extra Strength Headache | Lil' Drug Store Products, Inc. | DailyMed |
| Extra Strength Headache Relief | Advanced Rx LLC | DailyMed |
| Extra Strength Headache Relief | Lil' Drug Store Products, Inc. | DailyMed |
| Extra Strength Headache Relief | Walgreens | DailyMed |
| EXTRA STRENGTH Headache Relief geltabs | Strive Pharmaceuticals Inc. | DailyMed |
| Extra Strength Headache, Caseys 4good | Lil' Drug Store Products, Inc. | DailyMed |
| Extra Strength Headache, Circle K | Lil' Drug Store Products, Inc. | DailyMed |
| Extra Strength Headache, Lil Drug Store | Lil' Drug Store Products, Inc. | DailyMed |
Showing 25 of 55 brands.
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg · tablet, coated (oral) · 13 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Excedrin Migraine Geltabs | Haleon US Holdings LLC | DailyMed |
| Dg Health Headache Relief | Dolgencorp Inc | DailyMed |
| Dr Simi Extra Strength Acetaminophen 250 mg, Aspirin 250 mg, and Caffeine 65 mg | Farmacias De Similares TX LLC | DailyMed |
| Excedrin Extra Strength Geltabs | Haleon US Holdings LLC | DailyMed |
| Extra Strength Headache Relief | Dollar General | DailyMed |
| Extra Strength Headache Relief | Wal-Mart Stores Inc | DailyMed |
| Headache Relief | Kroger Company | DailyMed |
| Headache Relief | Strive Pharmaceuticals Inc. | DailyMed |
| Headache Relief | Target Corporation | DailyMed |
| Headache Relief | Walgreens | DailyMed |
| Headache Relief Extra Strength | P & L Development, LLC | DailyMed |
| Vanquish Extra Strength | DSE Healthcare Solutions, LLC | DailyMed |
| Walgreens Headache Relief Extra Strength | Walgreens | DailyMed |
Acetaminophen 325 mg · Aspirin 500 mg · Caffeine 65 mg · powder (oral) · 2 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Goodys Cool Orange Headache | Medtech Products Inc. | DailyMed |
| GOODYS Extra Strength Headache Mixed Fruit Blast | Medtech Products Inc. | DailyMed |
Acetaminophen 260 mg · Aspirin 520 mg · Caffeine 32.5 mg · powder (oral) · 2 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Goodys Extra Strength | Medtech Products Inc. | DailyMed |
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg · capsule (oral) · 2 products
Acetaminophen 500 mg · Aspirin 500 mg · Caffeine 65 mg · powder (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Bc Max | Medtech Products Inc. | DailyMed |
Acetaminophen 500 mg · Aspirin 500 mg · Caffeine 130 mg · powder (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Goodys Max | Medtech Products Inc. | — |
Acetaminophen 250 mg · Aspirin 250 mg · Caffeine 65 mg · capsule, coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Extra Strength Pain Reliever | JHK Inc dba American Safety & First Aid | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| acetaminophen 250 mg · aspirin 250 mg · caffeine 65 mg tablet | Generic | $0.0633 per tablet |
| acetaminophen 250 mg · aspirin 250 mg · caffeine 65 mg tablet, film coated | Generic | $0.0633 per tablet |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Lil' Drug Store Products, Inc.14 products
- Haleon US Holdings LLC12 products
- Walgreens8 products
- Medtech Products Inc.6 products
- CVS Pharmacy5 products
- Amazon.com Services LLC5 products
- Opmx LLC4 products
- Rite Aid Corporation3 products
- L. Perrigo Company3 products
- Chain Drug Marketing Association, Inc.3 products
- Navajo Manufacturing Company Inc.3 products
- Cardinal Health 110, LLC. dba Leader3 products
- TARGET Corporation3 products
- The Kroger Co.3 products
- Topco Associates LLC3 products
- Proficient Rx LP3 products
- Select Consumer Group2 products
- Amerisource Bergen2 products
- Wal-Mart Stores Inc2 products
- Strive Pharmaceuticals Inc.2 products
- Sportpharm LLC2 products
- H E B2 products
- Dolgencorp, LLC2 products
- Publix Super Markets Inc2 products
- Walgreen Company2 products
- Better Living Brands, LLC2 products
- Kroger Company2 products
- United Natural Foods, Inc. dba UNFI2 products
- Meijer Distribution Inc2 products
- Salado Sales, Inc.2 products
Showing the 30 companies with the most products, of 91.
Recalls
From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific products or lots: check the name and lot number on your package.
-
July 11, 2024 · Class I · Ongoing · D-0641-2024
Labeling: Missing Label - some bottles are missing the the manufacturers label that includes the drug facts information.
Healthy Living Acetaminophen, Aspirin (NSAID) and Caffeine, tablets USP, 250 mg/250 mg/65 mg, 100-count bottles, Distributed by: Aurohealth LLC, 279 Princeton-Hightstown Road, East Windsor, NJ , Made in India, NDC 58602- — Aurobindo Pharma USA Inc
-
August 19, 2014 · Class III · Terminated · D-1558-2014
Failed Dissolution Specifications and Failed Tablet Specifications: High 30 minute dissolution test and presence of broken lozenges.
Nicotine Polacrilex Lozenge, 2 mg Mint Mini. 27 Ct Tubes, Over the Counter. Perrigo, 502 Eastern Ave, Plant #6, Allegan, MI 49010. Labeled: A) CareOne, 81 and 108 Ct Cartons, Distributed by: Foodhold U.S.A., LLD, Landove — Perrigo Holland Inc
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.