Quick answers
- What is Acetaminophen and ibuprofen used for?
- The Drug Facts label of Advil Dual Action with Acetaminophen (Haleon US Holdings LLC) lists these uses: temporarily relieves minor aches and pains due to: o headache o toothache o backache o menstrual cramps o muscular aches o minor pain of arthritis.
- Do I need a prescription for Acetaminophen and ibuprofen?
- No, the products on this page are sold without a prescription. Other products with the same active ingredients need a prescription (often a higher strength or another form): see the prescription page.
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen and ibuprofen been recalled?
- FDA enforcement reports list 1 recall of products on this page; the newest started March 13, 2025. A recall usually concerns specific products or lots, not every brand.
Also sold by prescription (often at a higher strength or in another form): Acetaminophen and ibuprofen — prescription medicine
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Advil Dual Action with Acetaminophen · Haleon US Holdings LLC
Acetaminophen 250 mg · Ibuprofen 125 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Acetaminophen 250 mg Ibuprofen 125 mg (NSAID*) *nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever
Uses
- temporarily relieves minor aches and pains due to: o headache o toothache o backache o menstrual cramps o muscular aches o minor pain of arthritis
Warnings
- Acetaminophen liver damage warning: This product contains acetaminophen. Severe liver damage may occur if you take:
- with other drugs containing acetaminophen
- more than 6 caplets in 24 hours, which is the maximum daily amount for this product
- 3 or more alcoholic drinks every day while using this product
- Acetaminophen allergy alert: may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If skin reaction occurs, stop use and seek medical help right away.
- NSAID allergy alert: ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- skin reddening
- rash
- blisters If an allergic reaction occurs, stop use and seek medical help right away. NSAID stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others]
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
- if you have ever had an allergic reaction to acetaminophen or any other pain reliever
- right before or after heart surgery
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
Ask a doctor or pharmacist before use if
you are
- under a doctor's care for any serious condition
- taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
- taking any other drug
When using this product
- take with food or milk if stomach upset occurs
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding: o feel faint o vomit blood o have bloody or black stools o have stomach pain that does not get better
- you have symptoms of heart problems or stroke: o chest pain o trouble breathing o weakness in one part or side of body o slurred speech o leg swelling
- pain gets worse or lasts more than 10 days
- redness or swelling is present in the painful area
- any new symptoms appear
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
do not take more than directed
| adults and children 12 years and over |
|
| children under 12 years |
|
- do not take more than 6 caplets in 24 hours, unless directed by a doctor
Inactive ingredients
carnauba wax, colloidal silicon dioxide, croscarmellose sodium, ferric oxides, glyceryl dibehenate, hypromellose, pharmaceutical ink, polydextrose, polyethylene glycol, pregelatinized starch, titanium dioxide
Questions?
call weekdays 9 AM to 5 PM at 1-800-88-ADVIL
— FDA label of Advil Dual Action with Acetaminophen, Haleon US Holdings LLC, effective April 21, 2025. See the official label on DailyMed →
Acetaminophen and Ibuprofen (NSAID) · Rite Aid
Acetaminophen 250 mg · Ibuprofen 125 mg, tablet (oral)
Active ingredient (in each caplet)
Acetaminophen 250 mg Ibuprofen 125 mg (NSAID**) **nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever
Uses
- temporarily relieves minor aches and pains due to:
- headache
- toothache
- backache
- menstrual cramps
- muscular aches
- minor pain of arthritis
Warnings
- Acetaminophen liver damage warning: This product contains acetaminophen. Severe liver damage may occur if you take:
- with other drugs containing acetaminophen
- more than 6 caplets in 24 hours, which is the maximum daily amount for this product
- 3 or more alcoholic drinks every day while using this product
- Acetaminophen allergy alert: may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If skin reaction occurs, stop use and seek medical help right away.
- NSAID allergy alert: ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- skin reddening
- rash
- blisters If an allergic reaction occurs, stop use and seek medical help right away.
- NSAID stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others]
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed
- Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
- if you have ever had an allergic reaction to acetaminophen or any other pain reliever
- right before or after heart surgery
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
Ask a doctor or pharmacist before use if
you are
- under a doctor’s care for any serious condition
- taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
- taking any other drug
When using this product
- Take with food or milk if stomach upset occurs
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms of heart problems or stroke:
- chest pain
- trouble breathing
- weakness in one part or side of body
- slurred speech
- leg swelling
- pain gets worse or lasts more than 10 days
- redness or swelling is present in the painful area
- any new symptoms appear
If pregnant or breast-feeding
ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed adults and children 12 years and over
- take 2 caplets every 8 hours while symptoms persist children under 12 years
- ask a doctor
- do not take more than 6 caplets in 24 hours, unless directed by a doctor
Inactive ingredients
carnauba wax, colloidal silicon dioxide, croscarmellose sodium, crospovidone, ferric oxide red, ferric oxide yellow, hypromellose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, pregelatinized starch, sodium lauryl sulfate, stearic acid and titanium dioxide.
Questions?
call 1-877-770-3183 Mon-Fri 8:00 AM EST to 5:00 PM PST.
— FDA label of Acetaminophen and Ibuprofen (NSAID), Rite Aid, effective December 19, 2025. See the official label on DailyMed →
Dual Action Pain Relief · Allegiant Health
Acetaminophen 250 mg · Ibuprofen 125 mg, capsule (oral)
Active ingredient (s)
Acetaminophen 250 mg Ibuprofen 125 mg (NSAID**) **nonsteroidal anti-inflammatory drug
Purpose
Pain reliever Pain reliever
Uses
(s) temporarily relieves minor aches and pains due to: o headache o toothache o backache o menstrual cramps o muscular aches o minor pain of arthritis
Warnings
- Acetaminophen liver damage warning: This product contains acetaminophen. Severe liver damage may occur if you take: with other drugs containing acetaminophen more than 6 caplets in 24 hours, which is the maximum daily amount for this product 3 or more alcoholic drinks every day while using this product
- Acetaminophen allergy alert: may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If skin reaction occurs, stop use and seek medical help right away.
- NSAID allergy alert: ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs, stop use and seek medical help right away.
- NSAID stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed
- Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
- if you have ever had an allergic reaction to acetaminophen or any other pain reliever
- right before or after heart surgery
Ask a doctor before use if
- you have liver disease
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
Ask a doctor or pharmacist before use if
- under a doctor's care for any serious condition
- taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
- taking any other drug
When using this product
- take with food or milk if stomach upset occurs
Stop use and ask a doctor if
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms of heart problems or stroke:
- chest pain
- trouble breathing
- weakness in one part or side of body
- slurred speech
- leg swelling
- pain gets worse or lasts more than 10 days
- redness or swelling is present in the painful area
- any new symptoms appear
If pregnant or breastfeeding
ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
do not take more than directed adults and children 12 years and over: take 2 caplets every 8 hours while symptoms persist children under 12 years: ask a doctor do not take more than 6 caplets in 24 hours, unless directed by a doctor
Inactive ingredients
carnauba wax, colloidal silicon dioxide, croscarmellose sodium, crospovidone, ferric oxide red, ferric oxide yellow, hypromellose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, pregelatinized starch, sodium lauryl sulfate, stearic acid and titanium dioxide.
Questions?
/Comments Call 1-888-952-0050 Monday through Friday 9AM – 5PM EST.
— FDA label of Dual Action Pain Relief, Allegiant Health, effective March 29, 2024. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 250 mg · Ibuprofen 125 mg · tablet, film coated (oral) · 52 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Advil Dual Action with Acetaminophen | Haleon US Holdings LLC | DailyMed |
| Advil Dual Action with Acetaminophen | Lil' Drug Store Products, Inc. | DailyMed |
| Advil Dual Action with Acetaminophen | Navajo Manufacturing Company Inc. | DailyMed |
| Advil Dual Action with Acetaminophen | Select Consumer Group | DailyMed |
| ADVIL DUAL ACTION WITH ACETAMINOPHEN Back Pain | Haleon US Holdings LLC | DailyMed |
| Advil Dual Action with Acetaminophen, Travel BASIX | Lil' Drug Store Products, Inc. | DailyMed |
| Acetaminophen 250 mg and Ibuprofen 125 mg | Dr. Reddy's Labortories Inc | DailyMed |
| Acetaminophen 250 mg and Ibuprofen 125 mg | Marksans Pharma Limited | DailyMed |
| Acetaminophen 250 mg and Ibuprofen 125 mg | R J General Corporation | DailyMed |
| Acetaminophen and Ibuprofen | Amerisource Bergen | DailyMed |
| Acetaminophen and Ibuprofen | Aurohealth LLC | DailyMed |
| Acetaminophen and Ibuprofen | Bionpharma Inc. | DailyMed |
| Acetaminophen and Ibuprofen | CVS Pharmacy | DailyMed |
| Acetaminophen and Ibuprofen | Discount Drug Mart, Inc. | DailyMed |
| Acetaminophen and Ibuprofen | Kroger Company | DailyMed |
| Acetaminophen and Ibuprofen | L.N.K. International, Inc. | — |
| Acetaminophen and Ibuprofen | Meijer Distribution Inc | DailyMed |
| Acetaminophen and Ibuprofen | Walgreen Company | DailyMed |
| Acetaminophen and Ibuprofen Back Pain | Aurohealth LLC | DailyMed |
| Acetaminophen, Ibuprofen | Glenmark Therapeutics Inc., USA | DailyMed |
| Basic Care Dual Action | Amazon.com Services LLC | DailyMed |
| Careone Dual Action | Retail Business Services, LLC | DailyMed |
| Dg Health Dual Back Pain Reliever | Dolgencorp Inc | DailyMed |
| DG health dual pain reliever | Dolgencorp Inc | DailyMed |
| Dual Action | Amazon.com Services LLC | DailyMed |
Showing 25 of 48 brands.
Acetaminophen 250 mg · Ibuprofen 125 mg · tablet (oral) · 20 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Aacetaminophen and Ibuprofen | Granules USA, Inc. | DailyMed |
| Acetaminophen | Raonbio Corp | DailyMed |
| Acetaminophen 250 mg and Ibuprofen 125 mg | Sun Pharmaceutical Industries, Inc. | DailyMed |
| Acetaminophen and Ibuprofen | Cvs | DailyMed |
| Acetaminophen and Ibuprofen | Family Dollar | DailyMed |
| Acetaminophen and Ibuprofen | Granules Pharmaceuticals Inc. | — |
| Acetaminophen and Ibuprofen | LEADER/ Cardinal Health 110, Inc. | DailyMed |
| Acetaminophen and Ibuprofen | Rugby Laboratories | DailyMed |
| Acetaminophen and Ibuprofen | Wal-Mart Stores Inc. | DailyMed |
| Acetaminophen and Ibuprofen | Walgreens | DailyMed |
| Acetaminophen and Ibuprofen (NSAID) | Retail Business Services, LLC | DailyMed |
| Acetaminophen and Ibuprofen (NSAID) | Rite Aid | DailyMed |
| Acetaminophen and Ibuprofen (NSAID) | Wal-Mart Stores Inc. | DailyMed |
| Acetaminophen and Ibuprofen Back Pain | Granules Pharmaceuticals Inc. | — |
| Dual Action | Better Living Brands, LLC | DailyMed |
| Dual Action | Kroger Company | DailyMed |
| Dual Action Pain Relief | Target Corporation | DailyMed |
| Dual Action Pain Relief | Time Cap Laboratories, Inc. | DailyMed |
| Period Pills by Biikay | Kai Squared | DailyMed |
Acetaminophen 250 mg · Ibuprofen 125 mg · capsule (oral) · 1 product
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Dual Action Pain Relief | Allegiant Health | DailyMed |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| acetaminophen 250 mg · ibuprofen 125 mg tablet | Generic | $0.0934 per tablet |
| acetaminophen 250 mg · ibuprofen 125 mg tablet, film coated | Generic | $0.0934 per tablet |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Bionpharma Inc.4 products
- Walgreen Company3 products
- Walmart Inc.3 products
- Amazon.com Services LLC2 products
- Retail Business Services, LLC2 products
- Topco Associates LLC2 products
- Meijer, Inc.2 products
- Haleon US Holdings LLC2 products
- Amerisource Bergen2 products
- Dolgencorp Inc2 products
- Kroger Company2 products
- Cvs2 products
- Lil' Drug Store Products, Inc.2 products
- CVS Pharmacy2 products
- Granules Pharmaceuticals Inc.2 products
- L. Perrigo Company2 products
- Chain Drug Marketing Association Inc.2 products
- Wal-Mart Stores Inc.2 products
- Aurohealth LLC2 products
- Rugby Laboratories1 product
- Dr. Reddy's Labortories Inc1 product
- Sun Pharmaceutical Industries, Inc.1 product
- Granules USA, Inc.1 product
- R J General Corporation1 product
- Rite Aid Corporation1 product
- LEADER/ Cardinal Health 110, Inc.1 product
- Dr. Reddy's Laboratories Inc1 product
- Sportpharm LLC1 product
- L.N.K. International, Inc.1 product
- Allegiant Health1 product
Showing the 30 companies with the most products, of 50.
Recalls
From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific products or lots: check the name and lot number on your package.
-
March 13, 2025 · Class II · Ongoing · D-0347-2025
CGMP Deviations
Acetaminophen and Ibuprofen (NSAID) Tablets, 250 mg/125 mg a). 144-count packets (NDC# 72657-157-74), b). 216-count packets( 72657-157-76),Distributed by: Glenmark Therapeutics Inc., USA, Mahwah, NJ 07430, Product of Ind — Glenmark Pharmaceuticals Inc., USA
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.