Quick answers
- What is Acetaminophen and diphenhydramine used for?
- The Drug Facts label of Dr Simi Pain Reliever PM (Farmacias De Similares TX LLC) lists these uses: Temporarily relief of occasional headaches and minor aches and pains with accompanying sleeplessness. Directions Do not use more than directed (see overdose warning). Directions Adults and children 12 years and over Take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours. Children under 12 years Do not use.
- Do I need a prescription for Acetaminophen and diphenhydramine?
- No. The products on this page are sold without a prescription (over the counter).
- Is a store brand the same as the name brand?
- Products listed together below have the same active ingredients, in the same amount and the same form, as registered with the FDA. Inactive ingredients (such as colors, flavors and fillers) and package sizes can differ. Compare the “Active ingredient” box on both packages, and ask a pharmacist if you are not sure.
- Has Acetaminophen and diphenhydramine been recalled?
- No recall linked to these products appears in the FDA enforcement reports we use.
Drug Facts label
Every over-the-counter medicine must carry a “Drug Facts” box in the same order, set by FDA rules. Below is the label of one product for each common strength and form, quoted word for word. Your own package can differ (for example, children’s products have other directions): always follow the label on your package.
Dr Simi Pain Reliever PM · Farmacias De Similares TX LLC
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg, tablet, coated (oral)
Active ingredient
Drug Facts Active ingredients (in each caplet) Acetaminophen 500 mg Diphenhydramine HCl 25 mg
Purpose
Pupose Pain reliever Nighttime sleep aid
Uses
Temporarily relief of occasional headaches and minor aches and pains with accompanying sleeplessness. Directions Do not use more than directed (see overdose warning). Directions Adults and children 12 years and over Take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours. Children under 12 years Do not use
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take. More than 2 caplets in 24 hours, which is the maximum daily amount for this product. With other drugs containing acetaminophen. 3 or more alcoholicdrinks everyday while using this product.
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: Skin reddening Blisters Rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
With any other drug containing acetaminophen (prescription or not prescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. With any other product containing diphenhydramine, even one used on skin. In children under 12 years of age. If you have ever had an allergic reaction to this product or any of its ingredients.
Ask a doctor before use if
you have Liver disease. A breathing problem such as emphysema or chronic bronchitis. Trouble urinating due to an enlarged prostate gland. Glaucoma. Ask your doctor or pharmacist before use if you are Taking the blood thinning drug warfarin Taking sedative or tranquilizers.
When using this product
Drowsiness will occur Avoid alcoholic drinks Do not drive a motor vehicle or operate machinery.
Stop use and ask a doctor if
Sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness. Pain gets worse or lasts more than 10 days. Fever gets worse or lasts more than 3 days. Redness or swelling is present. New symptoms occur. These could be signs of a serious condition.
Keep out of reach of children
Keep out of reach of children
Directions
| Adults and children 12 years and over |
|
| Children under 12 years | Do not use |
Other information
Store at 25 °C (77°F) excursions permitted between 15-30°C (59-86°F) Read all product information before using. TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING
Inactive ingredients
FD&C Blue No. 1, FD&C Blue No. 2, Hypromellose, Magnesium stearate, Microcrystalline cellulose, Polyethylene glycol, Povidone, Pregelatinized starch, Purified water, Stearic Acid, Titanium dioxide.
Questions?
(855)-280-1079
— FDA label of Dr Simi Pain Reliever PM, Farmacias De Similares TX LLC, effective August 11, 2025. See the official label on DailyMed →
Extra Strength PM Pain Medicine · Amerisource Bergen
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg, tablet (oral)
Active ingredient
Acetaminophen 500 mg Diphenhydramine HCI 25 mg
Purpose
Pain Reliever Nighttime sleep aid
Uses
for the temporary relief of occasional headaches and minor aches and pains along with accompanying sleeplessness
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product
- Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- with any other product containing diphenhydramine, even one used on skin
- in children under 12 years of age
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- glaucoma
- difficulty urinating due to an enlarged prostate gland
Ask a doctor or pharmacist before use if
you are taking
- the blood thinning drug warfarin
- sedatives or tranquilizers
When using this product
- drowsiness will occur
- do not drive a motor vehicle or operate machinery after use
- avoid alcoholic drinks
Stop use and ask a doctor if
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness.
- pain gets worse or lasts for more that 10 days
- fever gets worse or lasts more than 3 days
- new symptoms occur
- redness or swelling is present.These may be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
do not take more than directed (see overdose warning)
| Adults and Children 12 years and over | Take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours. |
| Children under 12 years of age | Do not use |
Inactive ingredients
croscarmellose sodium, FD&C blue #1 lake, hypromellose, microcrystalline cellulose, PEG, povidone, silica, starch, stearic acid, titanium dioxide
Questions?
1-800-540-3765
— FDA label of Extra Strength PM Pain Medicine, Amerisource Bergen, effective October 1, 2024. See the official label on DailyMed →
Tylenol PM · Savings Distributors LLC
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg, tablet, film coated (oral)
Active ingredient (in each caplet)
Acetaminophen 500 mg Diphenhydramine HCl 25 mg Purpose Pain reliever Nighttime sleep aid
Purpose
Pain reliever Nighttime sleep aid
Uses
temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- with any other product containing diphenhydramine, even one used on skin
- in children under 12 years of age
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- trouble urinating due to an enlarged prostate gland
- glaucoma
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- drowsiness will occur
- avoid alcoholic drinks
- do not drive a motor vehicle or operate machinery
Stop use and ask a doctor if
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
- do not take more than directed (see overdose warning) adults and children
- take 2 caplets at bedtime 12 years and over
- do not take more than 2 caplets of this product in 24 hours children under 12 years do not use
Inactive ingredients
carnauba wax, crospovidone, FD&C blue no. 1 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide
Questions?
call 1-877-895-3665 (toll-free) or 215-273-8755 (collect)
— FDA label of Tylenol PM, Savings Distributors LLC, effective May 1, 2026. See the official label on DailyMed →
CVS Nighttime Sleep Aid · Cvs Pharmacy
Acetaminophen 1000 mg/30 mL · Diphenhydramine hydrochloride 50 mg/30 mL, liquid (oral)
Active ingredient (in each 30 mL)
Acetaminophen 1000 mg Diphenhydramine HCl 50 mg
Purpose
Pain reliever Nighttime sleep-aid
Uses
- for the temporary relief of occasional minor aches and pains with accompanying sleeplessness.
Warnings
Liver warning : This product contains acetaminophen. Severe liver damage may occur if
- adult takes more than 4 doses (30 mL each) in 24 hrs., which is the maximum daily amount for this product
- taken with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product Allergy Alert : Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- for children under 12 years of age
- with any other product containing diphenhydramine, even one used on skin.
Ask a doctor before use if
you have
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- glaucoma
- difficulty in urination due to enlargement of the prostate gland
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- avoid alcoholic beverages
- drowsiness will occur
- do not drive a motor vehicle or operate machinery
Stop use and ask a doctor if
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- new symptoms occur
- Sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only one dose (30 mL) per day (24 hours)
- Only use dose cup provided
| adults & children 12 yrs & over | 30 mL at bedtime |
| children under 12 yrs | do not use |
Inactive ingredients
citric acid, flavors, FD&C Blue No. 1, FD&C Red No. 40, glycerin, potassium citrate, propylene glycol, purified water, sodium benzoate, sorbitol, sucralose.
Questions?
1-866-467-2748
— FDA label of CVS Nighttime Sleep Aid, Cvs Pharmacy, effective August 14, 2026. See the official label on DailyMed →
Acetaminophen and Diphenhydramine HCL · Publix Supermarkets, Inc
Acetaminophen 500 mg · Diphenhydramine 25 mg, tablet (oral)
Active ingredient (in each caplet)
Acetaminophen USP, 500 mg Diphenhydramine HCl USP, 25 mg
Purpose
Pain reliever Nighttime sleep aid
Uses
temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- with any other product containing diphenhydramine, even one used on skin
- in children under 12 years of age
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- trouble urinating due to an enlarged prostate gland
- glaucoma
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- drowsiness will occur
- avoid alcoholic drinks
- do not drive a motor vehicle or operate machinery
Stop use and ask a doctor if
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur These could be signs of a serious condition
If pregnant or breast-feeding
ask a health professional before use
Keep out of reach of children
Keep out of reach of children
Directions
- do not take more than directed (see overdose warning) adults and children 12 years and over
- take 2 caplets at bedtime
- do not take more than 2 caplets of this product in 24 hours children under 12 years
- do not use
Inactive ingredients
carnauba wax, colloidal silicon dioxide, croscarmellose sodium, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, hypromellose, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone k-30, pregelatinized starch, stearic acid, titanium dioxide
Questions?
call 1-877-770-3183 Mon-Fri 8:00 AM EST to 5:00 PM PST
— FDA label of Acetaminophen and Diphenhydramine HCL, Publix Supermarkets, Inc, effective December 19, 2025. See the official label on DailyMed →
Equate Pain Relief Pm · Walmart Inc.
Acetaminophen 1000 mg/30 mL · Diphenhydramine hydrochloride 50 mg/30 mL, solution (oral)
Active ingredient (in each 30 mL)
Acetaminophen 1000 mg Diphenhydramine HCl 50 mg
Purpose
Pain reliever Nighttime sleep-aid
Uses
- for the temporary relief of occasional minor aches and pains with accompanying sleeplessness
Warnings
- Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
- Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away.
- Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- in children under 12 years of age
- with any other product containing diphenhydramine, even one used on skin
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- glaucoma
- difficulty in urination due to enlargement of the prostate gland
Ask a doctor or pharmacist before use if
you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
When using this product
- avoid alcoholic beverages
- drowsiness will occur
- do not drive a motor vehicle or operate machinery
Stop use and ask a doctor if
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness. These could be signs of a serious condition.
If pregnant or breast-feeding
ask a health professional before use.
Keep out of reach of children
- Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
take only one dose (30 mL) per day (24 hours)
- only use the dose cup provided
- take only as directed – see Overdose warning
| adults & children 12 yrs & over | 30 mL at bedtime |
| children under 12 yrs | do not use |
Other information
- each 30 mL contains: sodium 25 mg
- store at 20-25°C (68-77°F)
Inactive ingredients
alcohol, anhydrous citric acid, benzyl alcohol, FD&C blue #1, FD&C red #40, flavor, poloxamer 407, propylene glycol, purified water, saccharin sodium, sodium benzoate, sodium chloride, sodium citrate, sorbitol solution, sucralose, xanthan gum
Questions?
1-888-287-1915
— FDA label of Equate Pain Relief Pm, Walmart Inc., effective May 5, 2026. See the official label on DailyMed →
This page is not medical advice. Read the label on your package, and ask a pharmacist or doctor if you are not sure a medicine is right for you, for your child, or with your other medicines.
Same medicine, other brands
Each group lists the products that have exactly the same active ingredients, in the same amount and form, as registered with the FDA (NDC Directory). A store brand in the same group has the same medicine as the name brand; inactive ingredients, flavors and package sizes can differ. Each product links to its own official label.
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg · tablet, coated (oral) · 53 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen PM | AAA Pharmaceutical, Inc. | DailyMed |
| Acetaminophen PM | Chain Drug Marketing Association, Inc. | DailyMed |
| Acetaminophen PM | Costco Wholesale Corporation | — |
| Acetaminophen PM | Fsa Store Inc. | DailyMed |
| Acetaminophen PM | Grocery Outlet, Inc. | DailyMed |
| Acetaminophen PM | Harris Teeter | DailyMed |
| Acetaminophen Pm | Retail Business Services, LLC. | DailyMed |
| Acetaminophen PM Extra Strength | Chain Drug Marketing Association Inc | DailyMed |
| Acetaminophen PM Extra Strength | Cvs Pharmacy | DailyMed |
| Acetaminophen PM Extra Strength | Foodhold U.S.A., LLC | DailyMed |
| Acetaminophen Pm Extra Strength | Sam's West Inc | — |
| Acetaminophen PM Extra Strength | United Natural Foods, Inc. dba UNFI | DailyMed |
| Acetaminophen PM Extra Strength | WinCo Foods, LLC | DailyMed |
| Dr Simi Pain Reliever PM | Farmacias De Similares TX LLC | DailyMed |
| Extra Strength Pain Relief PM | Valu Merchandisers Company | DailyMed |
| Genexa Acetaminophen PM Extra Strength | Genexa Inc. | DailyMed |
| Pain Relief Acetaminophen PM | Rite Aid Corporation | DailyMed |
| Pain Relief PM | Amerifoods Trading Company | DailyMed |
| pain relief PM | Harris Teeter | DailyMed |
| Pain Relief PM | Hyvee Inc | DailyMed |
| Pain Relief PM | Safeway | DailyMed |
| Pain Relief PM | Strategic Sourcing Services LLC | DailyMed |
| Pain Relief PM | Topco Associates, LLC | DailyMed |
| Pain Relief PM Extra Strength | Chain Drug Marketing Association | DailyMed |
| Pain Relief PM Extra Strength | Chain Drug Marketing Association, Inc. | DailyMed |
Showing 25 of 48 brands.
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg · tablet (oral) · 43 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen and Diphenhydramine hydrochloride | Aurohealth LLC | DailyMed |
| Acetaminophen and Diphenhydramine hydrochloride | Better Living Brands, LLC | DailyMed |
| Acetaminophen and Diphenhydramine hydrochloride | Kroger Company | DailyMed |
| Acetaminophen and Diphenhydramine hydrochloride | Walmart Inc. | DailyMed |
| Acetaminophen Diphenhydramine HCl | Better Living Brands LLC. | DailyMed |
| Acetaminophen Diphenhydramine HCl | Granules USA, Inc. | DailyMed |
| Acetaminophen Diphenhydramine HCL | Walgreen Co. | DailyMed |
| Acetaminophen Diphenhydramine HCL | Walgreens Co. | DailyMed |
| Acetaminophen Pm | Advance Pharmaceutical Inc. | DailyMed |
| CAREALL Non-Aspirin PM Extra Strength | New World Imports, Inc | DailyMed |
| CAREALL Pain Relief PM Extra Strength | New World Imports, Inc | DailyMed |
| CounterAct PM | Melaleuca, Inc. | DailyMed |
| Cystex PM | Clarion Brands, LLC | DailyMed |
| Extra Strength Acetaminophen PM | BJWC (Berkley & Jensen / BJ's) | DailyMed |
| Extra Strength Acetaminophen PM | Kroger | — |
| Extra Strength Acetaminophen PM | Kroger Company | DailyMed |
| Extra strength Acetaminophen PM | Time Cap Labs Inc | DailyMed |
| Extra Strength Night Time Pain Medicine | Geri-Care Pharmaceutical Corp | DailyMed |
| Extra Strength Nite-Time Pain Relief | Walgreens | — |
| Extra Strength NiteTime Pain Relief | Walgreens | DailyMed |
| Extra Strength Pain Reliever PM | Ingles Markets, Inc. | DailyMed |
| Extra Strength Pain Reliever Pm | Walgreens Co. | DailyMed |
| Extra Strength Pain Reliever Pm | Walmart Inc. | DailyMed |
| Extra Strength PM Pain Medicine | Amerisource Bergen | DailyMed |
| GOOD REMEDIES Extra Strength Pain Relief PM Caplet | Strive Pharmaceuticals Inc. | DailyMed |
Showing 25 of 39 brands.
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg · tablet, film coated (oral) · 34 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen Pm | Amazon.com Services LLC | DailyMed |
| Acetaminophen PM | Major Pharmaceuticals | DailyMed |
| Acetaminophen Pm | Ulai Health LLC | DailyMed |
| Acetaminophen PM Extra Strength | Army and Air Force Exchange Service | DailyMed |
| Acetaminophen, Diphenhydramine HCL | CVS Pharmacy, Inc. | — |
| Acetaminophen, Diphenhydramine Hydrochloride | LEADER/ Cardinal Health 110, Inc. | DailyMed |
| Basic Care Acetaminophen Pm | Amazon.com Services LLC | DailyMed |
| CareOne Acetaminophen PM | American Sales Company | DailyMed |
| Dg Health Pain Relief Pm Extra Strength | Dolgencorp Inc | DailyMed |
| Good Sense Pain Relief Pm Extra Strength | Bryant Ranch Prepack | DailyMed |
| Good Sense Pain Relief Pm Extra Strength | L. Perrigo Company | DailyMed |
| Lil Drug Store Tylenol PM Extra Strength | Lil' Drug Store Products, Inc. | DailyMed |
| Pain Relief Acetaminophen PM Extra Strength | Rite Aid Corporation | DailyMed |
| Pain Relief PM | HyVee Inc | DailyMed |
| Pain Relief Pm Extra Strength | Publix Super Markets Inc | DailyMed |
| Pain Reliever PM | L.N.K. International, Inc. | DailyMed |
| Pain Reliever PM | Walgreen Company | DailyMed |
| Pain Reliever PM | Walmart Inc. | DailyMed |
| Pain Reliever PM Extra Strength | L.N.K. International, Inc. | DailyMed |
| Pain Reliever PM Extra Strength | Salado Sales, Inc. | DailyMed |
| Pain Reliever PM, Extra Strength, 24-7 Life by 7-Eleven | Lil' Drug Store Products, Inc. | DailyMed |
| Panadol Pm | Haleon US Holdings LLC | DailyMed |
| RIGHT REMEDIES EXTRA STRENGTH PM Pain Relief | Strive Pharmaceuticals Inc. | DailyMed |
| Tylenol PM | Savings Distributors LLC | DailyMed |
| Tylenol PM Extra Strength | Jones Healthcare Group - Packaging Services, Inc | DailyMed |
Showing 25 of 31 brands.
Acetaminophen 1000 mg/30 mL · Diphenhydramine hydrochloride 50 mg/30 mL · liquid (oral) · 7 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| CVS Nighttime Sleep Aid | Cvs Pharmacy | DailyMed |
| RiteAid Nighttime Sleep Aid | Rite Aid Corporation | DailyMed |
| Vicks PainQuil PM PAIN RELIEVER plus NIGHTTIME SLEEP-AID | The Procter & Gamble Manufacturing Company | — |
| Vicks ZzzQuil Night Pain | The Procter & Gamble Manufacturing Company | — |
| Vicks ZzzQuil NIGHT PAIN NIGHTTIME SLEEP-AID PAIN RELIEVER | The Procter & Gamble Manufacturing Company | — |
Acetaminophen 500 mg · Diphenhydramine 25 mg · tablet (oral) · 6 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen and Diphenhydramine HCL | Publix Supermarkets, Inc | DailyMed |
| Acetaminophen and Diphenhydramine HCL | Safeway | DailyMed |
| Acetaminophen and Diphenhydramine Hydrochloride | Bi-Mart | DailyMed |
| Acetaminophen Diphenhydramine HCl | Chain Drug Consortium, LLC | DailyMed |
| Acetaminophen Diphenhydramine HCL | Dr. Reddy's Laboratories Inc. | — |
| Acetaminophen Diphenhydramine HCL | Walgreens | DailyMed |
Acetaminophen 1000 mg/30 mL · Diphenhydramine hydrochloride 50 mg/30 mL · solution (oral) · 5 products
Drug Facts for this strength and form ↑
| Brand or product name | Company on the label | Label |
|---|---|---|
| Equate Pain Relief Pm | Walmart Inc. | DailyMed |
| Nighttime Pain Reliever plus Sleep Aid | Walmart Inc. | DailyMed |
| Pain Reliever plus Sleep Aid NightTime | Kroger Company | DailyMed |
| Sleep Aid Plus Pain Relief | Walgreen Company | DailyMed |
| TYLENOL PM Extra Strength | Kenvue Brands LLC | — |
Acetaminophen 650 mg · Diphenhydramine hydrochloride 25 mg · powder, for solution (oral) · 4 products
| Brand or product name | Company on the label | Label |
|---|---|---|
| Chloraseptic Nighttime Sore Throat Hot Relief | Prestige Brands Holdings, Inc. | DailyMed |
| Equate Severe Cold Cough and Flu | Walmart Inc. | DailyMed |
| Theraflu Severe Cold Relief Nighttime | Haleon US Holdings LLC | DailyMed |
| Vicks NyQuil HOT REMEDY Cold and Flu | Procter & Gamble Manufactura S de RL de CV | — |
Acetaminophen 325 mg · Diphenhydramine hydrochloride 25 mg · tablet, film coated (oral) · 2 products
Acetaminophen 650 mg/20 mL · Diphenhydramine hydrochloride 25 mg/20 mL · liquid (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu Nighttime | Haleon US Holdings LLC | DailyMed |
Acetaminophen 650 mg/30 mL · Diphenhydramine hydrochloride 25 mg/30 mL · syrup (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Theraflu Severe Cold Relief Nighttime | Haleon US Holdings LLC | DailyMed |
Acetaminophen 500 mg · Diphenhydramine hydrochloride 25 mg · capsule, gelatin coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| PAIN RELIEVER PM Extra Strength | Best Choice (Valu Merchandisers Company) | DailyMed |
Acetaminophen 320 mg/10 mL · Diphenhydramine hydrochloride 12.5 mg/10 mL · solution (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Dimetapp Multi-Symptom Cold and Flu | Foundation Consumer Healthcare | DailyMed |
Acetaminophen 325 mg · Diphenhydramine hydrochloride 12.5 mg · tablet, chewable (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Theraflu Severe Cold Relief Nighttime Soft Chews | Haleon US Holdings LLC | DailyMed |
Acetaminophen 325 mg · Diphenhydramine hydrochloride 12.5 mg · tablet, coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Percogesic Original Strength | Medtech Products Inc. | DailyMed |
Acetaminophen 325 mg · Diphenhydramine hydrochloride 50 mg · tablet, film coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Unisom PM Pain Nighttime Sleep Aid and Pain Reliever | Chattem, Inc. | DailyMed |
Acetaminophen 650 mg/20 mL · Diphenhydramine hydrochloride 25 mg/20 mL · solution (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime | Haleon US Holdings LLC | DailyMed |
Acetaminophen 500 mg · Diphenhydramine 12.5 mg · capsule, coated (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Percogesic Extra Strength | Medtech Products Inc. | DailyMed |
Acetaminophen 500 mg · Diphenhydramine citrate 38 mg · powder (oral) · 1 product
Acetaminophen 500 mg · Diphenhydramine citrate 38 mg · tablet (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Acetaminophen and Diphenhydramine citrate | InvaTech Pharma Solutions LLC | DailyMed |
Acetaminophen 500 mg · Diphenhydramine HCL 25 mg · capsule, liquid filled (oral) · 1 product
| Brand or product name | Company on the label | Label |
|---|---|---|
| Vicks PainQuil PM LIQUICAPS PAIN RELIEVER plus NIGHTTIME SLEEP-AID | The Procter & Gamble Manufacturing Company | — |
1 more strengths and forms are listed in the FDA NDC Directory.
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| acetaminophen 500 mg · diphenhydramine hydrochloride 25 mg tablet | Generic | $0.0445 per tablet |
| acetaminophen 500 mg · diphenhydramine hydrochloride 25 mg tablet, coated | Generic | $0.0445 per tablet |
| acetaminophen 500 mg · diphenhydramine hydrochloride 25 mg tablet, film coated | Generic | $0.0445 per tablet |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that sell this medicine
The company named on the package (maker or distributor), as listed in the FDA NDC Directory, with its number of over-the-counter products of this medicine.
- Walmart Inc.9 products
- The Procter & Gamble Manufacturing Company7 products
- Haleon US Holdings LLC7 products
- Walgreens5 products
- Lil' Drug Store Products, Inc.5 products
- Strategic Sourcing Services LLC4 products
- Rite Aid Corporation3 products
- L.N.K. International, Inc.3 products
- Walgreen Company3 products
- New World Imports, Inc3 products
- Strive Pharmaceuticals Inc.3 products
- Kroger Company3 products
- United Natural Foods, Inc. dba UNFI3 products
- Chain Drug Marketing Association Inc3 products
- Medtech Products Inc.3 products
- Pioneer Life Sciences, LLC2 products
- Better Living Brands LLC.2 products
- Kenvue Brands LLC2 products
- CVS Pharmacy, Inc.2 products
- QUALITY CHOICE (Chain Drug Marketing Association)2 products
- Marc Glassman, Inc.2 products
- Amazon.com Services LLC2 products
- Dolgencorp Inc2 products
- Safeway2 products
- Topco Associates, LLC2 products
- Cvs Pharmacy2 products
- Cabinet Health P.B.C.2 products
- HyVee Inc2 products
- Meijer, Inc.2 products
- Farmacias De Similares TX LLC2 products
Showing the 30 companies with the most products, of 99.
Recalls
No recall linked to these products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- FDA rule for the Drug Facts label (21 CFR 201.66)
Only medicines marketed under FDA rules for nonprescription drugs (an FDA monograph or an FDA approval) are listed. Homeopathic products are not listed: the FDA does not evaluate them for safety or effectiveness.