Quick answers
- What is Silver sulfadiazine used for?
- The FDA-approved label (Silvadene, Pfizer Laboratories Div Pfizer Inc, January 26, 2026) says: “SILVADENE Cream 1% (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.” This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
- Does Silver sulfadiazine have a boxed warning?
- No. None of the 20 FDA labels we found for this medicine has a boxed warning.
- Is there a shortage of Silver sulfadiazine?
- No current shortage is listed by the FDA for the products of this medicine (FDA data from October 30, 2026).
- Has Silver sulfadiazine been recalled?
- No recall linked to the products of this medicine appears in the FDA enforcement reports we use.
- Who makes Silver sulfadiazine?
- 12 companies list prescription products of Silver sulfadiazine in the FDA NDC Directory, including A-S Medication Solutions, Preferred Pharmaceuticals Inc. and NuCare Pharmaceuticals, Inc..
What Silver sulfadiazine is used for
Quoted from the “Indications and Usage” section of the FDA-approved label.
SILVADENE Cream 1% (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
— FDA label: Silvadene, Pfizer Laboratories Div Pfizer Inc, effective January 26, 2026. Read the full label on DailyMed →
The FDA has 20 labels for products of this medicine (different makers and forms); uses can differ between them. Check the label that comes with your own medicine.
This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
Conditions named on the label
These condition names appear word for word in the label’s “Indications and Usage” text (matched with a reviewed table). Each page lists hospitals whose own websites name the condition.
Related medical specialties
Boxed warning
A boxed warning (“black box”) is the FDA’s strongest warning on a drug label, for serious or life-threatening risks.
The label quoted above has no boxed warning.
0 of 20 FDA labels for this medicine have a boxed warning.
Forms and how it is given
| Dosage forms | Cream |
|---|---|
| Route | Topical |
| Prescription products | 20 in the FDA NDC Directory |
| Brand names | Ssd Cream, Silvadene, Thermazene Silver Sulfadiazine, Ssd |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| silver sulfadiazine 1% cream | Generic | $0.1294–$0.4046 per gram 12 packages, lowest to highest |
| silver sulfadiazine 1% cream | Brand: Silvadene | $0.1247–$0.4328 per gram 6 packages, lowest to highest |
| silver sulfadiazine 10 g/1000 g cream | Generic | $0.1294–$0.3248 per gram 5 packages, lowest to highest |
NADAC list of November 4, 2026; these prices took effect between September 23, 2026 and October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that list this medicine
Labelers in the FDA NDC Directory: the company named on the package (maker or distributor), with the number of prescription products.
- A-S Medication Solutions6 products
- Preferred Pharmaceuticals Inc.2 products
- NuCare Pharmaceuticals, Inc.2 products
- Asclemed USA, Inc.2 products
- Advanced Rx Pharmacy of Tennessee, LLC1 product
- Mylan Pharmaceuticals Inc.1 product
- Direct_Rx1 product
- Pfizer Laboratories Div Pfizer Inc1 product
- Ascend Laboratories, LLC1 product
- Dr.Reddys Laboratories Inc1 product
- Proficient Rx LP1 product
- St. Mary's Medical Park Pharmacy1 product
FDA approval history
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
| Application | Sponsor | Approved | Later changes approved |
|---|---|---|---|
| NDA017381 SILVADENE | King Pharms LLC | November 26, 1973 | 40, latest August 1, 2016 2016: Labeling · 2015: Manufacturing (CMC) · 2013: Labeling |
| NDA018578 SSD, SSD AF | DR Reddys | February 25, 1982 | 13, latest April 21, 2014 2014: Manufacturing (CMC) · 2000: Manufacturing (CMC) · 1999: Manufacturing (CMC) |
| NDA018810 THERMAZENE | Thepharmanetwork LLC | December 23, 1985 | 12, latest August 11, 2016 2016: Manufacturing (CMC) · 2012: Manufacturing (CMC) · 2001: Manufacturing (CMC) |
Shortage status
The FDA drug shortage list does not show these products.
Recalls
No recall linked to these products (by their NDC code) appears in the FDA enforcement reports.
Official identifiers
| RxCUI (RxNorm) | 106351, 208185, 208186 |
|---|---|
| SPL set ID of the quoted label | c437213a-1cd4-445e-a39f-bbcacb9f746f |
| FDA labels (SPL) | 20 |
| FDA applications | NDA017381, NDA018578, NDA018810 |
| Active ingredients (FDA) | SILVER SULFADIAZINE |
Sources
- FDA-approved label on DailyMed (National Library of Medicine) — Silvadene, Pfizer Laboratories Div Pfizer Inc, effective January 26, 2026; via openFDA, FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- Drug shortages (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
openFDA data is provided by the FDA as is; it may be incomplete. Always rely on the label that comes with your medicine. FDA Enforcement Report search →