Quick answers
- What is Penicillin g benzathine and penicillin g procaine used for?
- The FDA-approved label (Bicillin C-R 900/300, Pfizer Laboratories Div Pfizer Inc, July 21, 2026) says: “To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R 900/300 and other antibacterial drugs, Bicillin C-R 900/300 should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. …” This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
- Does Penicillin g benzathine and penicillin g procaine have a boxed warning?
- Yes. The FDA label for Bicillin C-R 900/300 has a boxed warning, the FDA’s strongest warning. Read it on the full label and ask your pharmacist.
- Is there a shortage of Penicillin g benzathine and penicillin g procaine?
- No current shortage is listed by the FDA for the products of this medicine (FDA data from October 30, 2026).
- Has Penicillin g benzathine and penicillin g procaine been recalled?
- No recall linked to the products of this medicine appears in the FDA enforcement reports we use.
- Who makes Penicillin g benzathine and penicillin g procaine?
- 1 company lists prescription products of Penicillin g benzathine and penicillin g procaine in the FDA NDC Directory, including Pfizer Laboratories Div Pfizer Inc.
What Penicillin g benzathine and penicillin g procaine is used for
Quoted from the “Indications and Usage” section of the FDA-approved label.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin C-R 900/300 and other antibacterial drugs, Bicillin C-R 900/300 should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. …
— FDA label: Bicillin C-R 900/300, Pfizer Laboratories Div Pfizer Inc, effective July 21, 2026. Read the full label on DailyMed →
The FDA has 2 labels for products of this medicine (different makers and forms); uses can differ between them. Check the label that comes with your own medicine.
This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
Conditions named on the label
These condition names appear word for word in the label’s “Indications and Usage” text (matched with a reviewed table). Each page lists hospitals whose own websites name the condition.
Related medical specialties
Boxed warning
A boxed warning (“black box”) is the FDA’s strongest warning on a drug label, for serious or life-threatening risks.
This label has a boxed warning. Read it on the full label →
2 of 2 FDA labels for this medicine have a boxed warning.
Forms and how it is given
| Dosage forms | Injection, suspension |
|---|---|
| Route | Intramuscular |
| Prescription products | 3 in the FDA NDC Directory |
| Brand names | Bicillin CR, Bicillin C-R 900/300 |
Companies that list this medicine
Labelers in the FDA NDC Directory: the company named on the package (maker or distributor), with the number of prescription products.
- Pfizer Laboratories Div Pfizer Inc3 products
FDA approval history
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
| Application | Sponsor | Approved | Later changes approved |
|---|---|---|---|
| NDA050138 BICILLIN C-R, BICILLIN C-R 900/300 | King Pharms LLC | May 18, 1953 | 230, latest June 25, 2026 2026: Labeling · 2026: Labeling · 2020: Labeling |
Shortage status
The FDA drug shortage list does not show these products.
Recalls
No recall linked to these products (by their NDC code) appears in the FDA enforcement reports.
Official identifiers
| RxCUI (RxNorm) | 731538, 731541, 836306, 836307 |
|---|---|
| SPL set ID of the quoted label | ba7b9199-4710-4189-a85d-77ed75befe4d |
| FDA labels (SPL) | 2 |
| FDA applications | NDA050138 |
| Active ingredients (FDA) | PENICILLIN G BENZATHINE / PENICILLIN G PROCAINE |
Sources
- FDA-approved label on DailyMed (National Library of Medicine) — Bicillin C-R 900/300, Pfizer Laboratories Div Pfizer Inc, effective July 21, 2026; via openFDA, FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- Drug shortages (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
openFDA data is provided by the FDA as is; it may be incomplete. Always rely on the label that comes with your medicine. FDA Enforcement Report search →