Quick answers
- Does Nitrous oxide have a boxed warning?
- No. None of the 35 FDA labels we found for this medicine has a boxed warning.
- Is there a shortage of Nitrous oxide?
- No current shortage is listed by the FDA for the products of this medicine (FDA data from October 30, 2026).
- Has Nitrous oxide been recalled?
- No recall linked to the products of this medicine appears in the FDA enforcement reports we use.
- Who makes Nitrous oxide?
- 42 companies list prescription products of Nitrous oxide in the FDA NDC Directory, including Roberts Oxygen Company, Inc., NexAir, LLC and AGL Welding Supply Co., Inc..
What Nitrous oxide is used for
We did not find an “Indications and Usage” section in the FDA labels for this medicine. See the label on DailyMed →
This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
Boxed warning
A boxed warning (“black box”) is the FDA’s strongest warning on a drug label, for serious or life-threatening risks.
The label quoted above has no boxed warning.
0 of 35 FDA labels for this medicine have a boxed warning.
Forms and how it is given
| Dosage forms | Gas |
|---|---|
| Route | Respiratory (inhalation) |
| Prescription products | 44 in the FDA NDC Directory |
Companies that list this medicine
Labelers in the FDA NDC Directory: the company named on the package (maker or distributor), with the number of prescription products.
- Roberts Oxygen Company, Inc.3 products
- NexAir, LLC1 product
- AGL Welding Supply Co., Inc.1 product
- General Air Service & Supply Co1 product
- Helget Gas Products1 product
- Westair Gases & Equipment, Inc.1 product
- Oxarc, LLC1 product
- Keen Compressed Gas Co. Inc.1 product
- Crumpton Welding Supply & Equipment, Inc.1 product
- Holston Gases, Inc1 product
- General Welding Supply Corp.1 product
- DJB Gas Services, Inc1 product
- Corrigan Propane LLC dba Blue Water Industrial Products1 product
- Red Ball Oxygen Co., Inc.1 product
- Analgesic Services Inc1 product
- Aero All Gas Company1 product
- Badger Welding Supplies, Inc.1 product
- Airtec Gases, LLC1 product
- Linde Gas & Equipment Inc.1 product
- Metro Welding Supply Corporation1 product
- Maverick Oxygen & Respiratory Equipment, LLC1 product
- Fullerton Welding Supply1 product
- Matheson Tri-Gas, Inc.1 product
- Spectrum Gas Products, Inc1 product
- Central Welding Supply Company1 product
- Machine & Welding Supply Company dba Arc3 Gases South1 product
- ILMO Products Company1 product
- United States Welding, Inc.1 product
- WSM Supplier LLC.1 product
- Nitrous Oxide1 product
- Quality Air Products Inc1 product
- Air Source Industries1 product
- Norco, Inc1 product
- American Welding & Gas1 product
- Agp LLC1 product
- DuPuy Oxygen & Supply Company, Inc.1 product
- Volunteer Welding Supply Inc1 product
- Lessors, Incorporated1 product
- Nitrous Oxide of Canada1 product
- Medical-Technical Gases, Inc.1 product
- All Gas & Welding Supplies Co., Inc.1 product
- MITCHELL WELDING SUPPLY DBA Meritus Texas1 product
FDA approval history
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
| Application | Sponsor | Approved | Later changes approved |
|---|---|---|---|
| NDA205704 NITROUS OXIDE, USP | Air Liquide America Speciality Gases | June 16, 2013 | — |
| NDA206009 NITROUS OXIDE, USP | Nitrous Oxide Corp | September 3, 2013 | — |
| NDA206014 NITROUS OXIDE, USP | Nitrous Oxide of Canada | September 6, 2013 | — |
| NDA209989 NITROUS OXIDE, USP | Matheson Tri-Gas Inc | January 9, 2017 | — |
Shortage status
The FDA drug shortage list does not show these products.
Recalls
No recall linked to these products (by their NDC code) appears in the FDA enforcement reports.
Official identifiers
| RxCUI (RxNorm) | 312022, 347046, 347166 |
|---|---|
| SPL set ID of the quoted label | 07aa2a86-d01e-470f-a12c-9908118bedc6 |
| FDA labels (SPL) | 35 |
| FDA applications | NDA205704, NDA206009, NDA206014, NDA209989 |
| Active ingredients (FDA) | NITROUS OXIDE |
Sources
- FDA-approved label on DailyMed (National Library of Medicine) — Nitrous Oxide, American Welding & Gas, effective October 8, 2026; via openFDA, FDA data exported October 30, 2026, retrieved October 31, 2026
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- Drug shortages (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
openFDA data is provided by the FDA as is; it may be incomplete. Always rely on the label that comes with your medicine. FDA Enforcement Report search →