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Prescription medicine · generic available

Ampicillin

Also listed by the FDA as: ampicillin sodium · ampicillin trihydrate

Full FDA label All drugs

Official FDA data, not advice

Everything here comes from the U.S. Food and Drug Administration (FDA): the drug label, the NDC Directory, Drugs@FDA, recall reports and the drug shortage list. Each fact shows its source and date.

This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.

In an emergency, call 911. If someone may have taken too much of a medicine, call Poison Help: 1‑800‑222‑1222.

At a glance

Some labelsBoxed warning
To be discontinuedFDA shortage list
2Recalls (FDA reports)
17Companies
1971First FDA approval on file

Quick answers

What is Ampicillin used for?
The FDA-approved label (Ampicillin, Henry Schein, Inc., July 31, 2026) says: “Ampicillin for injection is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the following conditions: Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus (penicillinase and nonpenicillinase-producing), H. influenzae, and Group A beta-hemolytic streptococci. Bacterial Meningitis caused by E. …” This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.
Does Ampicillin have a boxed warning?
The label we quote has no boxed warning, but 3 of 37 FDA labels for this medicine do. Check the label of your own product.
Is there a shortage of Ampicillin?
The FDA drug shortage list shows “To be discontinued” for a product of this medicine (updated December 8, 2025). Ask your pharmacist about alternatives.
Has Ampicillin been recalled?
FDA enforcement reports list 2 recalls of products of this medicine; the newest started April 13, 2022 (Class II). A recall usually concerns specific lots, not every product.
Who makes Ampicillin?
17 companies list prescription products of Ampicillin in the FDA NDC Directory, including Sandoz Inc, Medical Purchasing Solutions, LLC and WG Critical Care, LLC.

What Ampicillin is used for

Quoted from the “Indications and Usage” section of the FDA-approved label.

Ampicillin for injection is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the following conditions: Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus (penicillinase and nonpenicillinase-producing), H. influenzae, and Group A beta-hemolytic streptococci. Bacterial Meningitis caused by E. …

— FDA label: Ampicillin, Henry Schein, Inc., effective July 31, 2026. Read the full label on DailyMed →

The FDA has 37 labels for products of this medicine (different makers and forms); uses can differ between them. Check the label that comes with your own medicine.

This page is not medical advice. Talk to your doctor or pharmacist before you start, stop or change any medicine.

Conditions named on the label

These condition names appear word for word in the label’s “Indications and Usage” text (matched with a reviewed table). Each page lists hospitals whose own websites name the condition.

Sepsis

Related medical specialties

Infectious Disease

Boxed warning

A boxed warning (“black box”) is the FDA’s strongest warning on a drug label, for serious or life-threatening risks.

The label quoted above has no boxed warning.

3 of 37 FDA labels for this medicine have a boxed warning.

Forms and how it is given

Dosage formsInjection, powder, for solution · Powder, for solution · Capsule
RouteIntravenous · Intramuscular · Oral
Prescription products74 in the FDA NDC Directory

What pharmacies pay (NADAC)

The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.

This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.

NADAC per unit for Ampicillin, by strength and form
Strength and formGeneric or brandPharmacies pay
ampicillin trihydrate 500 mg
capsule		 Generic $0.4399 per capsule

NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.

Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →

Companies that list this medicine

Labelers in the FDA NDC Directory: the company named on the package (maker or distributor), with the number of prescription products.

FDA approval history

  • ANDA: Abbreviated New Drug Application: how a generic version is approved.

Generic approvals (13)

Shortage status

To be discontinued · updated December 8, 2025 · first posted December 8, 2025

ProductAmpicillin Sodium, Injection, 10 g (NDC 0781-9409-95)
CompanySandoz Inc.

Ask your pharmacist whether your product is affected and what the options are.

FDA Drug Shortages database →

Recalls

From FDA enforcement reports, matched by the product’s NDC code. A recall usually covers specific lots only: check the lot number on your package and ask your pharmacist. Do not stop a medicine on your own.

  1. April 13, 2022 · Class II · Terminated · D-1009-2022

    cGMP deviations: Temperature abuse

    Ampicillin for Injection, USP, 1 g per vial, 10-count box, Rx only, Distributed by: Auromedics Pharma, NDC 55150-113-10 — Mckesson Medical-Surgical Inc. Corporate Office

  2. September 25, 2017 · Class III · Terminated · D-1179-2017

    Labeling: Missing Label: customer complaint that some vials of ampicillin within the shrink wrap pack are missing labels.

    Ampicillin for Injection, USP, 500 mg per vial, single vial (NDC 0781-3407-78) packaged in 10-count shrink wrap packs (NDC 0781-3407-95), Rx only, Manufactured in Austria by Sandoz GmbH or Sandoz Inc., Princeton, NJ 0854 — Sandoz Inc

What do the recall classes mean?

Class I: The most serious type: there is a reasonable chance that using the product will cause serious health problems or death.
Class II: Using the product may cause temporary or medically reversible health problems, or the chance of serious problems is remote.
Class III: Using the product is not likely to cause health problems (for example a labeling or packaging issue).

Official identifiers

RxCUI (RxNorm)308207, 308212, 313800, 789980, 1721473, 1721474, 1721475, 1721476
SPL set ID of the quoted label78988f6a-a73b-4d3b-9a76-d61a748c3c16
FDA labels (SPL)37
FDA applications13 ANDA
Active ingredients (FDA)AMPICILLIN

Sources

  1. FDA-approved label on DailyMed (National Library of Medicine) — Ampicillin, Henry Schein, Inc., effective July 31, 2026; via openFDA, FDA data exported October 30, 2026, retrieved October 31, 2026
  2. NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
  3. Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
  4. Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
  5. Drug shortages (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026

openFDA data is provided by the FDA as is; it may be incomplete. Always rely on the label that comes with your medicine. FDA Enforcement Report search →

Report an error → · Information for medicine makers