Quick answers
- What is Entresto?
- Entresto is a brand name of Sacubitril and valsartan, a prescription medicine. The FDA NDC Directory lists 10 Entresto products in 5 strengths and forms.
- Who makes Entresto?
- Novartis Pharms Corp holds the FDA application for Entresto (NDA207620, approved July 7, 2015). 1 other company (repackagers or distributors) also list Entresto products.
- Is there a generic or store brand of Entresto?
- Yes. The FDA NDC Directory lists 73 other products with the same active ingredients, strength and form as a Entresto product, 73 of them generic. Ask your pharmacist whether one is right for you.
- What do pharmacies pay for Entresto?
- CMS lists a National Average Drug Acquisition Cost (NADAC) for 5 Entresto strengths and forms (see the table below). That is what pharmacies pay to buy it, not what you pay: your price depends on your insurance and your pharmacy.
- Has Entresto been recalled?
- No recall linked to Entresto products (by their NDC code or label) appears in the FDA enforcement reports we use.
What Entresto is
Each Entresto product as listed in the FDA NDC Directory, by active ingredient, strength and form, with its official label. “Same medicine, other names” counts the other products with exactly the same active ingredients, strength and form (generic versions, store brands and other brands); inactive ingredients can differ.
Sacubitril and valsartan · prescription medicine
| Strength and form | Product names | Same medicine, other names | Label |
|---|---|---|---|
| sacubitril 15 mg · valsartan 16 mg pellet (oral) | Entresto | None listed | DailyMed |
| sacubitril 24 mg · valsartan 26 mg tablet, film coated (oral) | Entresto | 24 products, 23 companies | DailyMed |
| sacubitril 49 mg · valsartan 51 mg tablet, film coated (oral) | Entresto | 24 products, 22 companies | DailyMed |
| sacubitril 6 mg · valsartan 6 mg pellet (oral) | Entresto | None listed | DailyMed |
| sacubitril 97 mg · valsartan 103 mg tablet, film coated (oral) | Entresto | 25 products, 22 companies | DailyMed |
Its page lists every product and company, the FDA label’s uses and boxed warning, approvals, shortages and recalls: Sacubitril and valsartan →
FDA approval
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| sacubitril 15 mg · valsartan 16 mg pellet | Brand: Entresto | $11.61 per unit |
| sacubitril 24 mg · valsartan 26 mg tablet, film coated | Brand: Entresto | $11.59 per tablet Generic of the same strength and form: $0.5020 per tablet |
| sacubitril 49 mg · valsartan 51 mg tablet, film coated | Brand: Entresto | $11.56 per tablet Generic of the same strength and form: $0.5427 per tablet |
| sacubitril 6 mg · valsartan 6 mg pellet | Brand: Entresto | $11.62 per unit |
| sacubitril 97 mg · valsartan 103 mg tablet, film coated | Brand: Entresto | $11.59 per tablet Generic of the same strength and form: $0.5804 per tablet |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that list Entresto
The company named on the package (holder, repackager or distributor), as listed in the FDA NDC Directory, with its number of Entresto products.
- Novartis Pharmaceuticals Corporation7 products
- Aphena Pharma Solutions - Tennessee, LLC3 products
Recalls
No recall linked to Entresto products (by their NDC code or label) appears in the FDA enforcement reports.
Sources
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- NADAC (National Average Drug Acquisition Cost) 2026 — Centers for Medicare & Medicaid Services (CMS), data.medicaid.gov, list of November 4, 2026, retrieved November 7, 2026
Which names get a brand page: a name the NDC Directory lists for a medicine, held by one company (the FDA application holder, or the company named on most of its products), that is not just a description, and that is not the only product of its medicine.