Depo-Medrol is a brand name of Methylprednisolone acetate, a prescription medicine. The FDA NDC Directory lists 10 Depo-Medrol products in 5 strengths and forms.

Who makes Depo-Medrol?

Pfizer holds the FDA application for Depo-Medrol (NDA011757, approved May 27, 1959). 2 other companies (repackagers or distributors) also list Depo-Medrol products.

Is there a generic or store brand of Depo-Medrol?

Yes. The FDA NDC Directory lists 34 other products with the same active ingredients, strength and form as a Depo-Medrol product, 34 of them generic. Ask your pharmacist whether one is right for you.

What do pharmacies pay for Depo-Medrol?

CMS lists a National Average Drug Acquisition Cost (NADAC) for 2 Depo-Medrol strengths and forms (see the table below). That is what pharmacies pay to buy it, not what you pay: your price depends on your insurance and your pharmacy.

Has Depo-Medrol been recalled?

FDA enforcement reports list 3 recalls of Depo-Medrol products; the newest started April 13, 2022. A recall usually concerns specific lots, not every product.

Depo-Medrol (Methylprednisolone acetate): maker, FDA approval and generic versions

Quick answers

What is Depo-Medrol?: Depo-Medrol is a brand name of Methylprednisolone acetate, a prescription medicine. The FDA NDC Directory lists 10 Depo-Medrol products in 5 strengths and forms.
Who makes Depo-Medrol?: Pfizer holds the FDA application for Depo-Medrol (NDA011757, approved May 27, 1959). 2 other companies (repackagers or distributors) also list Depo-Medrol products.
Is there a generic or store brand of Depo-Medrol?: Yes. The FDA NDC Directory lists 34 other products with the same active ingredients, strength and form as a Depo-Medrol product, 34 of them generic. Ask your pharmacist whether one is right for you.
What do pharmacies pay for Depo-Medrol?: CMS lists a National Average Drug Acquisition Cost (NADAC) for 2 Depo-Medrol strengths and forms (see the table below). That is what pharmacies pay to buy it, not what you pay: your price depends on your insurance and your pharmacy.
Has Depo-Medrol been recalled?: FDA enforcement reports list 3 recalls of Depo-Medrol products; the newest started April 13, 2022. A recall usually concerns specific lots, not every product.

What Depo-Medrol is

Each Depo-Medrol product as listed in the FDA NDC Directory, by active ingredient, strength and form, with its official label. “Same medicine, other names” counts the other products with exactly the same active ingredients, strength and form (generic versions, store brands and other brands); inactive ingredients can differ.

Methylprednisolone acetate · prescription medicine

Strength and form	Product names	Same medicine, other names	Label
methylprednisolone acetate 20 mg/mL injection, suspension (intralesional, intramuscular, intrasynovial, soft tissue)	Depo-Medrol	None listed	DailyMed
methylprednisolone acetate 40 mg/mL injection, suspension (intra-articular, intralesional, intramuscular, soft tissue)	Depo-Medrol	9 products, 7 companies	DailyMed
methylprednisolone acetate 40 mg/mL injection, suspension (intralesional, intramuscular, intrasynovial, soft tissue)	Depo-Medrol	9 products, 7 companies	DailyMed
methylprednisolone acetate 80 mg/mL injection, suspension (intralesional, intramuscular, intrasynovial, soft tissue)	Depo-Medrol	8 products, 6 companies	DailyMed
methylprednisolone acetate 80 mg/mL injection, suspension (intra-articular, intralesional, intramuscular, soft tissue)	Depo-Medrol	8 products, 6 companies	DailyMed

Its page lists every product and company, the FDA label’s uses and boxed warning, approvals, shortages and recalls: Methylprednisolone acetate →

FDA approval

NDA: New Drug Application: how a new (usually brand-name) medicine is approved.

FDA applications of Depo-Medrol products (Drugs@FDA)
Application	Holder	First approved	Products
NDA011757	Pfizer	May 27, 1959	10

What pharmacies pay (NADAC)

The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.

This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.

NADAC per unit for Depo-Medrol, by strength and form
Strength and form	Generic or brand	Pharmacies pay
methylprednisolone acetate 40 mg/mL injection, suspension	Brand: Depo-Medrol	$6.90 per mL Generic of the same strength and form: $5.57–$7.49 per mL
methylprednisolone acetate 80 mg/mL injection, suspension	Brand: Depo-Medrol	$11.65 per mL Generic of the same strength and form: $11.92 per mL

NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.

Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →

Companies that list Depo-Medrol

The company named on the package (holder, repackager or distributor), as listed in the FDA NDC Directory, with its number of Depo-Medrol products.

Pharmacia & Upjohn Company LLC5 products
A-S Medication Solutions4 products
Asclemed USA, Inc.1 product

Recalls

From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific lots: check the lot number on your package and ask your pharmacist. Do not stop a medicine on your own.

April 13, 2022 · Class II · Terminated · D-1096-2022

cGMP deviations: Temperature abuse

Depo-Medrol (methylprednisolone acetate injectable suspension, USP) 40 mg/mL, 1 mL single-dose vial, Rx only, MFG: Pfizer, NDC 0009-3073-03 — Mckesson Medical-Surgical Inc. Corporate Office
April 13, 2022 · Class II · Terminated · D-1097-2022

cGMP deviations: Temperature abuse

Depo-Medrol (methylprednisolone acetate injectable suspension, USP) 80mg/mL, packaged in a) 1 mL single-dose vial (NDC# 0009-3475-01), b) 25-count box (NDC 0009-3475-03), Rx only, MFG: Pfizer — Mckesson Medical-Surgical Inc. Corporate Office
July 30, 2014 · Class III · Terminated · D-1537-2014

Failed pH Specification: A pH result of 2.9 was obtained at the 9 month stability test interval at 25C/60%RH. The registered specification for pH is 3.0 - 7.0

Depo-Medrol (methylprednisolone acetate injectable suspension USP), 40 mg/ mL, 1 mL Single-Dose Vial, Rx only, Distributed by Pharmacia & Upjohn Co Division of Pfizer Inc, New York NY 10017 NDC 0009-3073-03 DEPO-MEDROL m — Pfizer Inc.

Sources

NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
NADAC (National Average Drug Acquisition Cost) 2026 — Centers for Medicare & Medicaid Services (CMS), data.medicaid.gov, list of November 4, 2026, retrieved November 7, 2026

Which names get a brand page: a name the NDC Directory lists for a medicine, held by one company (the FDA application holder, or the company named on most of its products), that is not just a description, and that is not the only product of its medicine.

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Depo-Medrol

Official data, not advice

At a glance