Quick answers
- What is Advair HFA?
- Advair HFA is a brand name of Fluticasone propionate and salmeterol, a prescription medicine. The FDA NDC Directory lists 5 Advair HFA products in 3 strengths and forms.
- Who makes Advair HFA?
- Glaxo GRP Ltd holds the FDA application for Advair HFA (NDA021254, approved June 8, 2006). 1 other company (repackagers or distributors) also list Advair HFA products.
- Is there a generic or store brand of Advair HFA?
- Yes. The FDA NDC Directory lists 3 other products with the same active ingredients, strength and form as a Advair HFA product, 3 of them generic. Ask your pharmacist whether one is right for you.
- What do pharmacies pay for Advair HFA?
- CMS lists a National Average Drug Acquisition Cost (NADAC) for 3 Advair HFA strengths and forms (see the table below). That is what pharmacies pay to buy it, not what you pay: your price depends on your insurance and your pharmacy.
- Has Advair HFA been recalled?
- FDA enforcement reports list 2 recalls of Advair HFA products; the newest started October 24, 2012. A recall usually concerns specific lots, not every product.
What Advair HFA is
Each Advair HFA product as listed in the FDA NDC Directory, by active ingredient, strength and form, with its official label. “Same medicine, other names” counts the other products with exactly the same active ingredients, strength and form (generic versions, store brands and other brands); inactive ingredients can differ.
Fluticasone propionate and salmeterol · prescription medicine
| Strength and form | Product names | Same medicine, other names | Label |
|---|---|---|---|
| fluticasone propionate 115 ug · salmeterol xinafoate 21 ug aerosol, metered (respiratory (inhalation)) | Advair HFA | 1 product, 1 company | DailyMed |
| fluticasone propionate 230 ug · salmeterol xinafoate 21 ug aerosol, metered (respiratory (inhalation)) | Advair HFA | 1 product, 1 company | DailyMed |
| fluticasone propionate 45 ug · salmeterol xinafoate 21 ug aerosol, metered (respiratory (inhalation)) | Advair HFA | 1 product, 1 company | DailyMed |
Its page lists every product and company, the FDA label’s uses and boxed warning, approvals, shortages and recalls: Fluticasone propionate and salmeterol →
FDA approval
- NDA: New Drug Application: how a new (usually brand-name) medicine is approved.
| Application | Holder | First approved | Products |
|---|---|---|---|
| NDA021254 | Glaxo GRP Ltd | June 8, 2006 | 5 |
What pharmacies pay (NADAC)
The National Average Drug Acquisition Cost (NADAC) is the average price U.S. retail pharmacies paid to buy one unit of a medicine (one tablet, one mL or one gram), from a monthly survey of pharmacy invoices by the Centers for Medicare & Medicaid Services (CMS). State Medicaid programs use it to pay pharmacies.
This is not the price you pay. What you pay depends on your insurance (copay or coinsurance), your pharmacy and any discounts, and pharmacies also charge for filling a prescription. Ask your pharmacist or your health plan what your price will be.
| Strength and form | Generic or brand | Pharmacies pay |
|---|---|---|
| fluticasone propionate 115 ug · salmeterol xinafoate 21 ug aerosol, metered | Brand: Advair HFA | $18.75–$25.39 per gram 2 packages, lowest to highest Generic of the same strength and form: $20.59 per gram |
| fluticasone propionate 230 ug · salmeterol xinafoate 21 ug aerosol, metered | Brand: Advair HFA | $30.53–$35.01 per gram 2 packages, lowest to highest Generic of the same strength and form: $27.15 per gram |
| fluticasone propionate 45 ug · salmeterol xinafoate 21 ug aerosol, metered | Brand: Advair HFA | $19.97–$20.02 per gram 2 packages, lowest to highest Generic of the same strength and form: $16.54 per gram |
NADAC list of November 4, 2026; these prices took effect on October 21, 2026. Shown only where a package’s NDC code matches the NADAC list exactly, and only for that exact strength and form: nothing is averaged across strengths. Strengths and forms not listed here have no NADAC price.
Source: NADAC (National Average Drug Acquisition Cost) 2026, data.medicaid.gov (CMS) →
Companies that list Advair HFA
The company named on the package (holder, repackager or distributor), as listed in the FDA NDC Directory, with its number of Advair HFA products.
- GlaxoSmithKline LLC3 products
- A-S Medication Solutions2 products
Recalls
From FDA enforcement reports, matched by the product’s NDC code or label. A recall usually covers specific lots: check the lot number on your package and ask your pharmacist. Do not stop a medicine on your own.
-
October 24, 2012 · Class III · Terminated · D-065-2013
Product Lacks Stability: These lots are being recalled due to the failure to meet the particle size distribution specification.
Advair HFA (fluticasone propionate/salmeterol) Inhalation Aerosol, 45mcg/21 mcg 60 Actuations INST, NDC 0173-0715-22, Rx only, GlaxoSmithKline, Research Triangle Park, NC 27709. — GlaxoSmithKline, LLC.
-
October 24, 2012 · Class III · Terminated · D-064-2013
Product Lacks Stability: These lots are being recalled due to the failure to meet the particle size distribution specification.
Advair HFA (fluticasone propionate 45 mcg and salmeterol 21 mcg) Inhalation Aerosol, 12g, 120 Metered Actuations, For Oral Inhalation with Advair HFA actuator only, Rx only, GlaxoSmithKline, Research Triangle Park, NC 27 — GlaxoSmithKline, LLC.
Sources
- NDC Directory (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drugs@FDA (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug labeling (SPL, openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 30, 2026, retrieved October 31, 2026
- Drug recall enforcement reports (openFDA) — U.S. Food and Drug Administration (FDA), FDA data exported October 27, 2026, retrieved October 31, 2026
- NADAC (National Average Drug Acquisition Cost) 2026 — Centers for Medicare & Medicaid Services (CMS), data.medicaid.gov, list of November 4, 2026, retrieved November 7, 2026
Which names get a brand page: a name the NDC Directory lists for a medicine, held by one company (the FDA application holder, or the company named on most of its products), that is not just a description, and that is not the only product of its medicine.